40S ribosomal protein S15a

RPS15A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS15A , S15a, ribosomal protein S15a, DBA20
External IDs	OMIM: 603674 MGI: 2389091 HomoloGene: 128982 GeneCards: RPS15A
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p12.3 Start 18,781,295 bp [1] End 18,790,383 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F1 Start 118,104,372 bp [2] End 118,116,188 bp [2]
Gene ontology Molecular function • structural constituent of ribosome • GO:0001948 protein binding • RNA binding Cellular component • cytoplasm • cytosol • ribosome • membrane • extracellular exosome • mitochondrion • nucleoplasm • extracellular matrix • cytosolic small ribosomal subunit Biological process • viral transcription • response to virus • SRP-dependent cotranslational protein targeting to membrane • positive regulation of cell cycle • positive regulation of cell proliferation • translational initiation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • rRNA processing • protein biosynthesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6210	267019
Ensembl	ENSG00000134419	ENSMUSG00000008683
UniProt	P62244	P62245
RefSeq (mRNA)	NM_001030009 NM_001019	NM_170669
RefSeq (protein)	NP_001010 NP_001025180	NP_733769
Location (UCSC)	Chr 16: 18.78 – 18.79 Mb	Chr 7: 118.1 – 118.12 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S15a is a protein that in humans is encoded by the RPS15A gene. ^{[5] [6]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000134419 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000008683 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
6. "Entrez Gene: RPS15A ribosomal protein S15a".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Chan YL, Olvera J, Paz V, Wool IG (1994). "The primary structure of rat ribosomal protein S15a". Biochem. Biophys. Res. Commun. 200 (3): 1498–504. doi:10.1006/bbrc.1994.1620. PMID   8185605.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC   139241 . PMID   12477932.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC   2253395 . PMID   15883184.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.