MRPS21

MRPS21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS21 , MRP-S21, RPMS21, MDS016, mitochondrial ribosomal protein S21, 28S ribosomal protein S21, mitochondrial
External IDs	OMIM: 611984 MGI: 1913542 HomoloGene: 45365 GeneCards: MRPS21
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.2 Start 150,293,861 bp [1] End 150,308,979 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.1 Start 95,769,946 bp [2] End 95,778,831 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons sperm pancreatic ductal cell Brodmann area 23 renal medulla external globus pallidus cerebellar vermis superior vestibular nucleus vena cava seminal vesicula Top expressed in interventricular septum plantaris muscle extensor digitorum longus muscle skeletal muscle tissue extraocular muscle yolk sac digastric muscle soleus muscle lip otic placode More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion mitochondrial small ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination mitochondrial translation protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54460 66292 Ensembl ENSG00000266472 ENSMUSG00000054312 UniProt P82921 P58059 RefSeq (mRNA) NM_031901 NM_018997 NM_078479 NM_001355759 RefSeq (protein) NP_061870 NP_114107 NP_510964 NP_001342688 Location (UCSC) Chr 1: 150.29 – 150.31 Mb Chr 3: 95.77 – 95.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S21, mitochondrial is a protein that in humans is encoded by the MRPS21 gene. ^{[5] [6]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and assist protein synthesis within the mitochondrion. ^[5] Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. ^[6] Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. ^[7] Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000266472 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054312 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, Watanabe K, Tanaka T (September 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
6. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (June 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. doi: 10.1074/jbc.M100727200 . PMID   11279123.
7. Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
8. "Entrez Gene: MRPS21 mitochondrial ribosomal protein S21".

Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi: 10.1074/jbc.M103236200 . PMID   11402041.
• Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. doi: 10.1074/jbc.M100727200 . PMID   11279123.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.