MRPS12

MRPS12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS12 , MPR-S12, MT-RPS12, RPMS12, RPS12, RPSM12, mitochondrial ribosomal protein S12
External IDs	OMIM: 603021 MGI: 1346333 HomoloGene: 6848 GeneCards: MRPS12
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.2 Start 38,930,944 bp [1] End 38,933,168 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B1 Start 28,439,066 bp [2] End 28,441,245 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ventricle right lobe of liver kidney right adrenal gland gastrocnemius muscle left adrenal gland body of stomach fundus prefrontal cortex spleen Top expressed in yolk sac islet of Langerhans parotid gland seminal vesicula left lobe of liver anterior horn of spinal cord temporal muscle triceps brachii muscle neural tube sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding structural constituent of ribosome Cellular component small ribosomal subunit mitochondrial inner membrane ribosome intracellular anatomical structure mitochondrial ribosome mitochondrion mitochondrial small ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6183 24030 Ensembl ENSG00000283018 ENSG00000128626 ENSMUSG00000045948 UniProt O15235 O35680 RefSeq (mRNA) NM_033363 NM_021107 NM_033362 NM_011885 NM_001360250 NM_001360252 NM_001360254 RefSeq (protein) NP_066930 NP_203526 NP_203527 NP_036015 NP_001347179 NP_001347181 NP_001347183 Location (UCSC) Chr 19: 38.93 – 38.93 Mb Chr 7: 28.44 – 28.44 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S12, mitochondrial is a protein that in humans is encoded by the MRPS12 gene. ^{[5] [6] [7]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein. ^[7]

References

1. ENSG00000128626 GRCh38: Ensembl release 89: ENSG00000283018, ENSG00000128626 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045948 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shah ZH, Migliosi V, Miller SC, Wang A, Friedman TB, Jacobs HT (Jun 1998). "Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus". Genomics. 48 (3): 384–8. doi:10.1006/geno.1997.5166. PMID   9545647.
6. Johnson DF, Hamon M, Fischel-Ghodsian N (Dec 1998). "Characterization of the human mitochondrial ribosomal S12 gene". Genomics. 52 (3): 363–8. doi:10.1006/geno.1998.5448. PMID   9790755.
7. "Entrez Gene: MRPS12 mitochondrial ribosomal protein S12".

Further reading

• Shah ZH, O'Dell KM, Miller SC, et al. (1998). "Metazoan nuclear genes for mitoribosomal protein S12". Gene. 204 (1–2): 55–62. doi:10.1016/S0378-1119(97)00521-0. PMID   9434165.
• Mariottini P, Shah ZH, Toivonen JM, et al. (1999). "Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation". J. Biol. Chem. 274 (45): 31853–62. doi: 10.1074/jbc.274.45.31853 . PMID   10542210.
• Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present" (PDF). J. Biol. Chem. 276 (22): 19363–74. doi: 10.1074/jbc.M100727200 . PMID   11279123. S2CID   26254238.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi: 10.1074/jbc.M103236200 . PMID   11402041.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Cui YP, Wang JB, Zhang XY, et al. (2003). "Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene". World J. Gastroenterol. 9 (9): 1892–6. doi: 10.3748/wjg.v9.i9.1892 . PMC   4656638 . PMID   12970870.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.