Mitochondrial ribosomal protein L13

MRPL13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL13 , L13, L13A, L13mt, RPL13, RPML13, mitochondrial ribosomal protein L13
External IDs	OMIM: 610200 MGI: 2137218 HomoloGene: 90894 GeneCards: MRPL13
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q24.12 Start 120,380,761 bp [1] End 120,445,402 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 D1 Start 55,397,490 bp [2] End 55,421,144 bp [2]
RNA expression pattern Bgee Top expressed in Ganglionic eminence Right adrenal gland islet of Langerhans rectum Stromal cell of endometrium Left adrenal gland Achilles tendon left ventricle right ventricle Right lobe of liver More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome GO:0001948 protein binding mRNA binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrion mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis negative regulation of translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	28998	68537
Ensembl	ENSG00000172172	ENSMUSG00000022370
UniProt	Q9BYD1	Q9D1P0
RefSeq (mRNA)	NM_014078	NM_026759
RefSeq (protein)	NP_054797	NP_081035
Location (UCSC)	Chr 8: 120.38 – 120.45 Mb	Chr 15: 55.4 – 55.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial ribosomal protein L13 is a protein that in humans is encoded by the MRPL13 gene. ^[5]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

References

1. GRCh38: Ensembl release 89: ENSG00000172172 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022370 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Mitochondrial ribosomal protein L13" . Retrieved 2017-07-05.

Further reading

• Mukhopadhyay R, Ray PS, Arif A, Brady AK, Kinter M, Fox PL (2008). "DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression". Mol. Cell. 32 (3): 371–82. doi:10.1016/j.molcel.2008.09.019. PMC   2644327 . PMID   18995835.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.