EIF2B1

EIF2B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ECS
Identifiers
Aliases	EIF2B1 , EIF2B, EIF2BA, eukaryotic translation initiation factor 2B subunit alpha, EIF2Balpha
External IDs	OMIM: 606686; MGI: 2384802; HomoloGene: 1080; GeneCards: EIF2B1; OMA:EIF2B1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q24.31 Start 123,620,406 bp [1] End 123,633,766 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 F|5 63.67 cM Start 124,708,276 bp [2] End 124,717,194 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte monocyte Achilles tendon body of uterus skin of hip skin of thigh right coronary artery granulocyte tibial arteries Top expressed in zygote secondary oocyte morula morula primary oocyte yolk sac primitive streak embryo epiblast blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor activity guanyl-nucleotide exchange factor activity protein binding identical protein binding Cellular component cytoplasm cytosol membrane plasma membrane eukaryotic translation initiation factor 2B complex Biological process response to peptide hormone response to heat response to glucose cell metabolism oligodendrocyte development protein biosynthesis translational initiation T cell receptor signaling pathway regulation of translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1967 209354 Ensembl ENSG00000111361 ENSMUSG00000029388 UniProt Q14232 Q99LC8 RefSeq (mRNA) NM_001414 NM_145371 RefSeq (protein) NP_001405 NP_663346 Location (UCSC) Chr 12: 123.62 – 123.63 Mb Chr 5: 124.71 – 124.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene. ^[5]

Interactions

EIF2B1 has been shown to interact with EIF2B5. ^{[6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000111361 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029388 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa".
6. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
7. Anthony TG, Fabian JR, Kimball SR, Jefferson LS (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID   10858531.

Further reading

• Hershey JW (1991). "Translational control in mammalian cells". Annu. Rev. Biochem. 60: 717–55. doi:10.1146/annurev.bi.60.070191.003441. PMID   1883206.
• Flowers KM, Mellor H, Kimball SR, Jefferson LS (1996). "Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B". Biochim. Biophys. Acta. 1264 (2): 163–7. doi:10.1016/0167-4781(95)00160-i. PMID   7495858.
• Welsh GI, Miyamoto S, Price NT, Safer B, Proud CG (1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. 271 (19): 11410–3. doi: 10.1074/jbc.271.19.11410 . PMID   8626696.
• Yang W, Hinnebusch AG (1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol. Cell. Biol. 16 (11): 6603–16. doi:10.1128/MCB.16.11.6603. PMC   231662 . PMID   8887689.
• Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). "A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B". J. Biol. Chem. 272 (31): 19099–102. doi: 10.1074/jbc.272.31.19099 . PMID   9235896.
• Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B". J. Biol. Chem. 273 (5): 3039–44. doi: 10.1074/jbc.273.5.3039 . PMID   9446619.
• Gomez E, Pavitt GD (2000). "Identification of Domains and Residues within the ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel Activation Function Promoted by eIF2B Complex Formation". Mol. Cell. Biol. 20 (11): 3965–76. doi:10.1128/MCB.20.11.3965-3976.2000. PMC   85753 . PMID   10805739.
• Anthony TG, Fabian JR, Kimball SR, Jefferson LS (2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID   10858531.
• Williams DD, Price NT, Loughlin AJ, Proud CG (2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein". J. Biol. Chem. 276 (27): 24697–703. doi: 10.1074/jbc.M011788200 . PMID   11323413.
• van der Knaap MS, Leegwater PA, Könst AA, Visser A, Naidu S, Oudejans CB, Schutgens RB, Pronk JC (2002). "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter". Ann. Neurol. 51 (2): 264–70. doi:10.1002/ana.10112. PMID   11835386. S2CID   1849575.
• Fogli A, Dionisi-Vici C, Deodato F, Bartuli A, Boespflug-Tanguy O, Bertini E (2003). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation". Neurology. 59 (12): 1966–8. doi:10.1212/01.wnl.0000041666.76863.47. PMID   12499492. S2CID   13129517.
• Fogli A, Rodriguez D, Eymard-Pierre E, Bouhour F, Labauge P, Meaney BF, Zeesman S, Kaneski CR, Schiffmann R, Boespflug-Tanguy O (2003). "Ovarian Failure Related to Eukaryotic Initiation Factor 2B Mutations". Am. J. Hum. Genet. 72 (6): 1544–50. doi:10.1086/375404. PMC   1180314 . PMID   12707859.
• van der Knaap MS, van Berkel CG, Herms J, van Coster R, Baethmann M, Naidu S, Boltshauser E, Willemsen MA, Plecko B, Hoffmann GF, Proud CG, Scheper GC, Pronk JC (2004). "eIF2B-Related Disorders: Antenatal Onset and Involvement of Multiple Organs". Am. J. Hum. Genet. 73 (5): 1199–207. doi:10.1086/379524. PMC   1180499 . PMID   14566705.
• Richardson JP, Mohammad SS, Pavitt GD (2004). "Mutations Causing Childhood Ataxia with Central Nervous System Hypomyelination Reduce Eukaryotic Initiation Factor 2B Complex Formation and Activity". Mol. Cell. Biol. 24 (6): 2352–63. doi:10.1128/MCB.24.6.2352-2363.2004. PMC   355856 . PMID   14993275.
• Li W, Wang X, Van Der Knaap MS, Proud CG (2004). "Mutations Linked to Leukoencephalopathy with Vanishing White Matter Impair the Function of the Eukaryotic Initiation Factor 2B Complex in Diverse Ways". Mol. Cell. Biol. 24 (8): 3295–306. doi:10.1128/MCB.24.8.3295-3306.2004. PMC   381664 . PMID   15060152.
• Van Haren K, van der Voorn JP, Peterson DR, van der Knaap MS, Powers JM (2004). "The life and death of oligodendrocytes in vanishing white matter disease". J. Neuropathol. Exp. Neurol. 63 (6): 618–30. doi: 10.1093/jnen/63.6.618 . PMID   15217090.
• Yin X, Warner DR, Roberts EA, Pisano MM, Greene RM (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID   15752756.