EIF2B1

EIF2B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ECS
Identifiers
Aliases	EIF2B1 , EIF2B, EIF2BA, eukaryotic translation initiation factor 2B subunit alpha, EIF2Balpha
External IDs	OMIM: 606686 MGI: 2384802 HomoloGene: 1080 GeneCards: EIF2B1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	123,633,766 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	124,717,194 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; monocyte; ; Achilles tendon; ; right coronary artery; ; body of pancreas; ; left uterine tube; ; right adrenal gland; ; subcutaneous adipose tissue; ; left coronary artery;
	Top expressed in
	secondary oocyte; ; morula; ; yolk sac; ; primitive streak; ; temporal muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; neural tube; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	translation initiation factor activity ; guanyl-nucleotide exchange factor activity ; protein binding ; identical protein binding ;
Cellular component	cytoplasm ; cytosol ; membrane ; plasma membrane ; eukaryotic translation initiation factor 2B complex ;
Biological process	response to peptide hormone ; response to heat ; response to glucose ; cell metabolism ; oligodendrocyte development ; protein biosynthesis ; translational initiation ; T cell receptor signaling pathway ; regulation of translational initiation ;
	Sources:Amigo / QuickGO
Orthologs
	1967
	209354
	ENSG00000111361
	ENSMUSG00000029388
	Q14232
	Q99LC8
	NM_001414
	NM_145371
	NP_001405
	NP_663346
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 02, 2023

Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene.^[5]

Interactions

EIF2B1 has been shown to interact with EIF2B5.^[6]^[7]

Related Research Articles

Leukoencephalopathy with vanishing white matter is an autosomal recessive neurological disease. The cause of the disease are mutations in any of the 5 genes encoding subunits of the translation initiation factor eIF2B: EIF2B1, EIF2B2, EIF2B3, EIF2B4, or EIF2B5. The disease belongs to a family of conditions called the Leukodystrophies.

Eukaryotic translation initiation factor 4E-binding protein 1 is a protein that in humans is encoded by the EIF4EBP1 gene.

Eukaryotic translation initiation factor 4 gamma 2 is a protein that in humans is encoded by the EIF4G2 gene.

Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.

Translation initiation factor eIF-2B subunit epsilon is a protein that in humans is encoded by the EIF2B5 gene.

Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.

Eukaryotic translation initiation factor 3 subunit A (eIF3a) is a protein that in humans is encoded by the EIF3A gene. It is one of the subunits of Eukaryotic initiation factor 3 (eIF3) a multiprotein complex playing major roles in translation initiation in eukaryotes.

Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.

Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene.

Translation initiation factor eIF-2B subunit gamma is a protein that in humans is encoded by the EIF2B3 gene.

Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.

Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene.

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.

<span class="mw-page-title-main">EIF1</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene. It is related to yeast SUI1.

Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene.

Eukaryotic Initiation Factor 2 (eIF2) is an eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates the binding of tRNA_i^Met to the ribosome in a GTP-dependent manner. eIF2 is a heterotrimer consisting of an alpha, a beta, and a gamma subunit.

The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA.

In molecular biology, the protein domain eIF4-gamma/eIF5/eIF2-epsilon is a family of evolutionarily related proteins. This domain is found at the C-terminus of several translation Initiation factors. It was first detected at the very C-termini of the yeast protein GCD6, eIF-2B epsilon, and two other eukaryotic translation initiation factors, eIF-4 gamma and eIF-5 and it may be involved in the interaction of eIF-2B, eIF-4 gamma, and eIF-5 with eIF-2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111361 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029388 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa".
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
↑ Anthony TG, Fabian JR, Kimball SR, Jefferson LS (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.

Hershey JW (1991). "Translational control in mammalian cells". Annu. Rev. Biochem. 60: 717–55. doi:10.1146/annurev.bi.60.070191.003441. PMID 1883206.
Flowers KM, Mellor H, Kimball SR, Jefferson LS (1996). "Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B". Biochim. Biophys. Acta. 1264 (2): 163–7. doi:10.1016/0167-4781(95)00160-i. PMID 7495858.
Welsh GI, Miyamoto S, Price NT, Safer B, Proud CG (1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. 271 (19): 11410–3. doi: 10.1074/jbc.271.19.11410 . PMID 8626696.
Yang W, Hinnebusch AG (1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol. Cell. Biol. 16 (11): 6603–16. doi:10.1128/MCB.16.11.6603. PMC 231662 . PMID 8887689.
Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). "A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B". J. Biol. Chem. 272 (31): 19099–102. doi: 10.1074/jbc.272.31.19099 . PMID 9235896.
Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B". J. Biol. Chem. 273 (5): 3039–44. doi: 10.1074/jbc.273.5.3039 . PMID 9446619.
Gomez E, Pavitt GD (2000). "Identification of Domains and Residues within the ɛ Subunit of Eukaryotic Translation Initiation Factor 2B (eIF2Bɛ) Required for Guanine Nucleotide Exchange Reveals a Novel Activation Function Promoted by eIF2B Complex Formation". Mol. Cell. Biol. 20 (11): 3965–76. doi:10.1128/MCB.20.11.3965-3976.2000. PMC 85753 . PMID 10805739.
Anthony TG, Fabian JR, Kimball SR, Jefferson LS (2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.
Williams DD, Price NT, Loughlin AJ, Proud CG (2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein". J. Biol. Chem. 276 (27): 24697–703. doi: 10.1074/jbc.M011788200 . PMID 11323413.
van der Knaap MS, Leegwater PA, Könst AA, Visser A, Naidu S, Oudejans CB, Schutgens RB, Pronk JC (2002). "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter". Ann. Neurol. 51 (2): 264–70. doi:10.1002/ana.10112. PMID 11835386. S2CID 1849575.
Fogli A, Dionisi-Vici C, Deodato F, Bartuli A, Boespflug-Tanguy O, Bertini E (2003). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation". Neurology. 59 (12): 1966–8. doi:10.1212/01.wnl.0000041666.76863.47. PMID 12499492. S2CID 13129517.
Fogli A, Rodriguez D, Eymard-Pierre E, Bouhour F, Labauge P, Meaney BF, Zeesman S, Kaneski CR, Schiffmann R, Boespflug-Tanguy O (2003). "Ovarian Failure Related to Eukaryotic Initiation Factor 2B Mutations". Am. J. Hum. Genet. 72 (6): 1544–50. doi:10.1086/375404. PMC 1180314 . PMID 12707859.
van der Knaap MS, van Berkel CG, Herms J, van Coster R, Baethmann M, Naidu S, Boltshauser E, Willemsen MA, Plecko B, Hoffmann GF, Proud CG, Scheper GC, Pronk JC (2004). "eIF2B-Related Disorders: Antenatal Onset and Involvement of Multiple Organs". Am. J. Hum. Genet. 73 (5): 1199–207. doi:10.1086/379524. PMC 1180499 . PMID 14566705.
Richardson JP, Mohammad SS, Pavitt GD (2004). "Mutations Causing Childhood Ataxia with Central Nervous System Hypomyelination Reduce Eukaryotic Initiation Factor 2B Complex Formation and Activity". Mol. Cell. Biol. 24 (6): 2352–63. doi:10.1128/MCB.24.6.2352-2363.2004. PMC 355856 . PMID 14993275.
Li W, Wang X, Van Der Knaap MS, Proud CG (2004). "Mutations Linked to Leukoencephalopathy with Vanishing White Matter Impair the Function of the Eukaryotic Initiation Factor 2B Complex in Diverse Ways". Mol. Cell. Biol. 24 (8): 3295–306. doi:10.1128/MCB.24.8.3295-3306.2004. PMC 381664 . PMID 15060152.
Van Haren K, van der Voorn JP, Peterson DR, van der Knaap MS, Powers JM (2004). "The life and death of oligodendrocytes in vanishing white matter disease". J. Neuropathol. Exp. Neurol. 63 (6): 618–30. doi: 10.1093/jnen/63.6.618 . PMID 15217090.
Yin X, Warner DR, Roberts EA, Pisano MM, Greene RM (2005). "Identification of novel CBP interacting proteins in embryonic orofacial tissue". Biochem. Biophys. Res. Commun. 329 (3): 1010–7. doi:10.1016/j.bbrc.2005.02.075. PMID 15752756.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111361 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029388 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa".

[pmid17353931-6] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

[pmid10858531-7] Anthony TG, Fabian JR, Kimball SR, Jefferson LS (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531.

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EIF2B1

Contents

Interactions

Related Research Articles

References

Further reading