RPS25 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | RPS25 , S25, ribosomal protein S25 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 180465 MGI: 1922867 HomoloGene: 133893 GeneCards: RPS25 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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40S ribosomal protein S25 (eS25) is a protein that in humans is encoded by the RPS25 gene. [5] [6]
Ribosomes are cellular macromolecules that catalyze protein synthesis across all kingdoms of life. The eukaryotic ribosome consists of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 distinct proteins. The RPS25 gene encodes the eukaryote-specific ribosomal protein eS25 that is a component of the 40S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [6]
Besides the interactions that position eS25 at its location in the E site region of the 40S ribosomal subunit, eS25 has been suggested to interact with other cellular proteins. One study has found that eS25 interacts with MDM2 as part of a regulatory feedback loop that stabilizes p53. [7] Additionally, eS25 has been shown to interact with CDC5L. [8]
As a ribosomal protein, eS25 likely plays a role in general protein synthesis; however, the RPS25 gene is non-essential for cellular viability in budding yeast and in select mammalian cell lines, implying that it is not essential for eukaryotic protein synthesis. [9] [10] Studies have implicated eS25 in the control of several specialized forms of translation, including that mediated by viral IRESs. [11] [12]
U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the SNRPA gene.
Protein phosphatase 1D is an enzyme that in humans is encoded by the PPM1D gene.
40S ribosomal protein S16' is a protein that in humans is encoded by the RPS16 gene.
40S ribosomal protein S9 is a protein that in humans is encoded by the RPS9 gene.
40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene.
60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.
60S ribosomal protein L28 is a protein that in humans is encoded by the RPL28 gene.
40S ribosomal protein S5 is a ribosomal subunit of the Eukaryotic ribosome (80S) complex. In humans it is encoded by the RPS5 gene.
40S ribosomal protein S30 is a protein that in humans is encoded by the FAU gene.
60S ribosomal protein L36 is a protein that in humans is encoded by the RPL36 gene.
40S ribosomal protein S24 is a protein that in humans is encoded by the RPS24 gene.
60S ribosomal protein L35 is a protein that in humans is encoded by the RPL35 gene.
40S ribosomal protein S7 is a protein that in humans is encoded by the RPS7 gene.
40S ribosomal protein S18 is a protein that in humans is encoded by the RPS18 gene.
60S ribosomal protein L13 is a protein that in humans is encoded by the RPL13 gene.
40S ribosomal protein S11 is a protein that in humans is encoded by the RPS11 gene.
40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.
Pleiotropic regulator 1 is a protein that in humans is encoded by the PLRG1 gene.
40S ribosomal protein S15a is a protein that in humans is encoded by the RPS15A gene.
60S ribosomal protein L37a is a protein that in humans is encoded by the RPL37A gene.