60S ribosomal protein L35a

RPL35A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J92, 4UJC, 3J7P, 4UJE, 3J7Q, 3J7R, 4D67, 4UJD, 4D5Y, 3J7O
Identifiers
Aliases	RPL35A , DBA5, L35A, ribosomal protein L35a, eL33
External IDs	OMIM: 180468 MGI: 1928894 HomoloGene: 129020 GeneCards: RPL35A
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q29 Start 197,950,190 bp [1] End 197,956,610 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B3 Start 32,876,823 bp [2] End 32,880,559 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence canal of the cervix endothelial cell monocyte right uterine tube gastric mucosa lactiferous duct skin of abdomen left uterine tube body of pancreas Top expressed in thymus lens spleen yolk sac lip bone marrow ileum uterus esophagus ganglionic eminence More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding tRNA binding RNA binding structural constituent of ribosome Cellular component cytosol ribosome membrane intracellular anatomical structure cytosolic large ribosomal subunit extracellular exosome extracellular matrix Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane ribosomal large subunit biogenesis translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6165 57808 Ensembl ENSG00000182899 ENSMUSG00000060636 UniProt P18077 O55142 RefSeq (mRNA) NM_000996 NM_001316311 NM_001130484 NM_001130485 NM_021338 RefSeq (protein) NP_000987 NP_001303240 NP_001123956 NP_001123957 NP_067313 Location (UCSC) Chr 3: 197.95 – 197.96 Mb Chr 16: 32.88 – 32.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L35a is a protein that in humans is encoded by the RPL35A gene. ^{[5] [6] [7]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript variants utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000182899 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060636 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Feo S, Davies B, Fried M (Jun 1992). "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome". Genomics. 13 (1): 201–7. doi:10.1016/0888-7543(92)90221-D. PMID   1577483.
6. Colombo P, Read M, Fried M (Sep 1996). "The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter". Genomics. 32 (1): 148–50. doi:10.1006/geno.1996.0093. PMID   8786106.
7. "Entrez Gene: RPL35A ribosomal protein L35a".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Herzog H, Höfferer L, Schneider R, Schweiger M (1990). "cDNA encoding the human homologue of rat ribosomal protein L35a". Nucleic Acids Res. 18 (15): 4600. doi:10.1093/nar/18.15.4600. PMC   331293 . PMID   2388839.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID   7821789.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
• Kroes RA, Jastrow A, McLone MG, et al. (2000). "The identification of novel therapeutic targets for the treatment of malignant brain tumors". Cancer Lett. 156 (2): 191–8. doi:10.1016/S0304-3835(00)00462-6. PMID   10880769.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Lopez CD, Martinovsky G, Naumovski L (2002). "Inhibition of cell death by ribosomal protein L35a". Cancer Lett. 180 (2): 195–202. doi:10.1016/S0304-3835(02)00024-1. PMID   12175552.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kasai H, Nadano D, Hidaka E, et al. (2003). "Differential expression of ribosomal proteins in human normal and neoplastic colorectum". J. Histochem. Cytochem. 51 (5): 567–74. doi:10.1177/002215540305100502. PMID   12704204. S2CID   25865715.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• GeneReviews/NCBI/NIH/UW entry on Diamond-Blackfan Anemia