Mitochondrial ribosomal protein L4

MRPL4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M,%%s3J7Y, 3J9M
Identifiers
Aliases	MRPL4 , CGI-28, L4mt, mitochondrial ribosomal protein L4
External IDs	OMIM: 611823 MGI: 2137210 HomoloGene: 32286 GeneCards: MRPL4
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.2 Start 10,251,901 bp [1] End 10,260,055 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A3 Start 20,914,034 bp [2] End 20,920,135 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Right adrenal gland Left adrenal gland right lobe of liver left ventricle skin of abdomen gastrocnemius muscle body of stomach prefrontal cortex oocyte left uterine tube Top expressed in interventricular septum myocardium of ventricle right ventricle extensor digitorum longus muscle brown adipose tissue internal carotid artery adrenal gland external carotid artery thoracic diaphragm digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome protein binding RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion cytosolic ribosome mitochondrial large ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51073 66163 Ensembl ENSG00000105364 ENSMUSG00000003299 UniProt Q9BYD3 Q9DCU6 RefSeq (mRNA) NM_015956 NM_146387 NM_146388 NM_023167 NM_001357899 RefSeq (protein) NP_057040 NP_666499 NP_666500 NP_057040.2 NP_666499.1 NP_075656 NP_001344828 Location (UCSC) Chr 19: 10.25 – 10.26 Mb Chr 9: 20.91 – 20.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L4, mitochondrial is a protein that in humans is encoded by the MRPL4 gene. ^[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000105364 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003299 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MRPL4 mitochondrial ribosomal protein L4".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
• Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi: 10.1074/jbc.M100432200 . PMID   11279069.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9BYD3 (39S ribosomal protein L4, mitochondrial) at the PDBe-KB .