Bbc1
Bbc1 (Mti1p) is a protein expressed in yeasts that is thought to associate with actin networks. Bbc1 is short for Bni1 synthetic lethal and Bee1 (las17) complex member. [8] The alternate name, Mti1p, is short for Myosin tail region-interacting protein. [9] Bbc1 is involved in cytoskeletal regulation during endocytosis. Budding yeast Bbc1 inhibits the activator of the Arp2/3 complex Las17 (WASp homolog). [10] The protein also interacts with the tail of Myosin 1 proteins. [9]
In fission yeast, Bbc1 is considered a WIP family cytoskeletal protein. Bbc1 localizes to actin cortical patches, cell division sites, the cell tip, and the cytosol. Cells with bbc1 gene deletion are viable. [11] Bbc1 is affinity captured by the Nebulin-family actin filament anchoring protein Cyk3 [12] and the SMARCAD1 family ATP-dependent DNA helicase Fft3. [11] [13] Bbc1 competes with WIP homolog Vrp1 to bind the Myosin 1 tail to regulate actin assembly at endocytic sites. [14]
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