60S ribosomal protein L12

Last updated
RPL12
Protein RPL12 PDB 1wib.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases RPL12 , L12, ribosomal protein L12
External IDs OMIM: 180475; MGI: 98002; HomoloGene: 128047; GeneCards: RPL12; OMA:RPL12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000976

NM_009076

RefSeq (protein)

NP_000967

NP_033102

Location (UCSC) Chr 9: 127.45 – 127.45 Mb Chr 2: 32.85 – 32.86 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene. [5] [6]

Contents

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [6]

Interactions

RPL12 has been shown to interact with CDC5L. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000197958 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038900 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chu W, Presky DH, Swerlick RA, Burns DK (March 1993). "The primary structure of human ribosomal protein L12". Nucleic Acids Res. 21 (3): 749. doi:10.1093/nar/21.3.749. PMC   309184 . PMID   8441690.
  6. 1 2 "Entrez Gene: RPL12 ribosomal protein L12".
  7. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC   305846 . PMID   11101529.

Further reading