60S ribosomal protein L23

RPL23
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7R, 4V5Z, 4V6X, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 5AJ0, 3J7Q, 4UG0, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL23 , L23, rpL17, ribosomal protein L23
External IDs	OMIM: 603662 MGI: 1929455 HomoloGene: 68103 GeneCards: RPL23
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q12 Start 38,847,860 bp [1] End 38,853,764 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 D|11 61.1 cM Start 97,668,353 bp [2] End 97,673,263 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right uterine tube monocyte canal of the cervix right lung left uterine tube left lobe of thyroid gland right lobe of thyroid gland skin of abdomen gastric mucosa Top expressed in yolk sac lip morula superior frontal gyrus mirror spermatid neural tube medullary collecting duct spermatocyte proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of ribosome large ribosomal subunit rRNA binding protein binding RNA binding transcription coactivator binding ubiquitin protein ligase binding ubiquitin ligase inhibitor activity Cellular component cytosol ribosome membrane focal adhesion extracellular exosome cytosolic large ribosomal subunit extracellular matrix nucleoplasm cytoplasm nucleolus postsynaptic density protein-containing complex Biological process ribosomal protein import into nucleus viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing negative regulation of transcription by RNA polymerase II positive regulation of cell population proliferation positive regulation of gene expression protein-DNA complex disassembly positive regulation of transcription by RNA polymerase II protein stabilization cellular response to actinomycin D positive regulation of signal transduction by p53 class mediator negative regulation of ubiquitin protein ligase activity negative regulation of ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9349 65019 Ensembl ENSG00000125691 ENSMUSG00000071415 UniProt P62829 P62830 RefSeq (mRNA) NM_000978 NM_022891 RefSeq (protein) NP_000969 NP_075029 Location (UCSC) Chr 17: 38.85 – 38.85 Mb Chr 11: 97.67 – 97.67 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L23 is a protein that in humans is encoded by the RPL23 gene. ^{[5] [6]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as RPL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000125691 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000071415 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Herault Y, Michel D, Chatelain G, Brun G (Aug 1991). "cDNA and predicted amino acid sequences of the human ribosomal protein genes rpS12 and rpL17". Nucleic Acids Res. 19 (14): 4001. doi:10.1093/nar/19.14.4001. PMC   328500 . PMID   1861993.
6. "Entrez Gene: RPL23 ribosomal protein L23".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Berchtold MW, Berger MC (1991). "Isolation and analysis of a human cDNA highly homologous to the yeast gene encoding L17A ribosomal protein". Gene. 102 (2): 283–8. doi:10.1016/0378-1119(91)90091-O. PMID   1874450.
• Yaseen NR, Blobel G (1997). "Cloning and characterization of human karyopherin β3". Proc. Natl. Acad. Sci. U.S.A. 94 (9): 4451–6. Bibcode:1997PNAS...94.4451Y. doi: 10.1073/pnas.94.9.4451 . PMC   20743 . PMID   9114010.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Shi Y, Zhai H, Wang X, et al. (2004). "Ribosomal proteins S13 and L23 promote multidrug resistance in gastric cancer cells by suppressing drug-induced apoptosis". Exp. Cell Res. 296 (2): 337–46. doi:10.1016/j.yexcr.2004.02.009. PMID   15149863.
• Dai MS, Lu H (2004). "Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5". J. Biol. Chem. 279 (43): 44475–82. doi: 10.1074/jbc.M403722200 . PMID   15308643.
• Dai MS, Zeng SX, Jin Y, et al. (2004). "Ribosomal Protein L23 Activates p53 by Inhibiting MDM2 Function in Response to Ribosomal Perturbation but Not to Translation Inhibition". Mol. Cell. Biol. 24 (17): 7654–68. doi:10.1128/MCB.24.17.7654-7668.2004. PMC   506971 . PMID   15314173.
• Jin A, Itahana K, O'Keefe K, Zhang Y (2004). "Inhibition of HDM2 and Activation of p53 by Ribosomal Protein L23". Mol. Cell. Biol. 24 (17): 7669–80. doi:10.1128/MCB.24.17.7669-7680.2004. PMC   506972 . PMID   15314174.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.