40S ribosomal protein S29

RPS29
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 4D61, 5FLX, 4KZX, 4D5L, 4V5Z, 4UJD, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS29 , DBA13, S29, ribosomal protein S29, uS14
External IDs	OMIM: 603633 MGI: 107681 HomoloGene: 83197 GeneCards: RPS29
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q21.3 Start 49,570,984 bp [1] End 49,599,164 bp [1]
Gene ontology Molecular function • structural constituent of ribosome • zinc ion binding • metal ion binding Cellular component • cytosol • ribosome • focal adhesion • intracellular anatomical structure • cytosolic small ribosomal subunit • small ribosomal subunit • extracellular exosome • nucleoplasm • cytoplasm • endoplasmic reticulum • rough endoplasmic reticulum • polysomal ribosome • cytoplasmic side of rough endoplasmic reticulum membrane Biological process • viral transcription • SRP-dependent cotranslational protein targeting to membrane • translational initiation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • protein biosynthesis • rRNA processing • cytoplasmic translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6235	20090
Ensembl	ENSG00000213741	ENSMUSG00000034892
UniProt	P62273	P62274
RefSeq (mRNA)	NM_001032 NM_001030001 NM_001351375	NM_009093
RefSeq (protein)	NP_001023 NP_001025172 NP_001338304	NP_033119
Location (UCSC)	Chr 14: 49.57 – 49.6 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S29 is a protein that in humans is encoded by the RPS29 gene. ^{[4] [5] [6]}

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[6]

Clinical significance

Mutations in RPS29 cause Diamond–Blackfan anemia. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000213741 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Kondoh N, Noda M, Fisher RJ, Schweinfest CW, Papas TS, Kondoh A, Samuel KP, Oikawa T (August 1996). "The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1313 (1): 41–6. doi: 10.1016/0167-4889(96)00052-3 . PMID   8781548.
5. Frigerio JM, Dagorn JC, Iovanna JL (May 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1262 (1): 64–8. doi:10.1016/0167-4781(95)00045-i. PMID   7772601.
6. "Entrez Gene: RPS29 ribosomal protein S29".
7. Mirabello L, Macari ER, Jessop L, Ellis SR, Myers T, Giri N, Taylor AM, McGrath KE, Humphries JM, Ballew BJ, Yeager M, Boland JF, He J, Hicks BD, Burdett L, Alter BP, Zon L, Savage SA (July 2014). "Whole-exome sequencing and functional studies identify RPS29 as a novel gene mutated in multicase Diamond-Blackfan anemia families". Blood. 124 (1): 24–32. doi:10.1182/blood-2013-11-540278. PMC   4125351 . PMID   24829207.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochemistry and Cell Biology. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Vladimirov SN, Ivanov AV, Karpova GG, Musolyamov AK, Egorov TA, Thiede B, Wittmann-Liebold B, Otto A (July 1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". European Journal of Biochemistry. 239 (1): 144–9. doi: 10.1111/j.1432-1033.1996.0144u.x . PMID   8706699.
• Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (May 1998). "A map of 75 human ribosomal protein genes". Genome Research. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
• Coppock D, Kopman C, Gudas J, Cina-Poppe DA (March 2000). "Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29". Biochemical and Biophysical Research Communications. 269 (2): 604–10. doi:10.1006/bbrc.2000.2324. PMID   10708601.
• Bortoluzzi S, d'Alessi F, Romualdi C, Danieli GA (December 2001). "Differential expression of genes coding for ribosomal proteins in different human tissues". Bioinformatics. 17 (12): 1152–7. doi: 10.1093/bioinformatics/17.12.1152 . PMID   11751223.
• Yoshihama M, Uechi T, Asakawa S, Kawasaki K, Kato S, Higa S, Maeda N, Minoshima S, Tanaka T, Shimizu N, Kenmochi N (March 2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Research. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Zhou ZD, Bao L, Liu DG, Li MQ, Ge YZ, Huang YL, Liu WY (February 2003). "Low content of protein S29 in ribosomes of human lung cancer cell line a549: detected by two-dimensional electrophoresis". Protein and Peptide Letters. 10 (1): 91–7. doi:10.2174/0929866033408273. PMID   12625830.
• Yu Y, Ji H, Doudna JA, Leary JA (June 2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Science. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC   2253395 . PMID   15883184.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.