60S ribosomal protein L17

RPL17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4V5Z, 4UJD, 5A8L, 4D67, 3J92, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL17 , L17, PD-1, RPL23, ribosomal protein L17
External IDs	OMIM: 603661 MGI: 2448270 HomoloGene: 115574 GeneCards: RPL17
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q21.1 Start 49,488,453 bp [1] End 49,492,523 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 E3 Start 75,131,629 bp [2] End 75,136,452 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube endometrium anterior pituitary Achilles tendon left lobe of thyroid gland body of pancreas canal of the cervix cerebellar hemisphere islet of Langerhans right lobe of thyroid gland Top expressed in uterus spleen thymus ganglionic eminence lens zone of skin pancreas bone marrow ovary ileum More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding structural constituent of ribosome RNA binding Cellular component cytosol ribosome large ribosomal subunit intracellular anatomical structure cytosolic large ribosomal subunit nucleus Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6139 319195 Ensembl ENSG00000265681 ENSMUSG00000062328 UniProt P18621 Q9CPR4 Q6ZWZ7 RefSeq (mRNA) NM_001199345 NM_000985 NM_001035006 NM_001199340 NM_001199341 NM_001199342 NM_001199343 NM_001199344 NM_001002239 RefSeq (protein) NP_000976 NP_001030178 NP_001186269 NP_001186270 NP_001186271 NP_001186272 NP_001186273 NP_001186274 NP_001356484 NP_001356485 NP_001356486 NP_001356487 NP_001356489 NP_001356490 NP_001356491 NP_001356492 NP_001002239 NP_001392893 NP_001392894 NP_001392895 Location (UCSC) Chr 18: 49.49 – 49.49 Mb Chr 18: 75.13 – 75.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Large ribosomal subunit protein uL22 is a protein that in humans is encoded by the RPL17 gene. ^{[5] [6] [7]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as RPL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Haloarcula marismortui ; however, its official symbol is RPL17. Two alternative splice variants have been observed, each encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[7]

See also

• Mitochondrial ribosomal protein L22, another human protein of uL22 (L22p or L17e) family

References

1. GRCh38: Ensembl release 89: ENSG00000265681 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062328 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mager DL, Freeman JD (Oct 1990). "A human gene related to the ribosomal protein L23 gene of Halobacterium marismortui". Nucleic Acids Res. 18 (17): 5301. doi:10.1093/nar/18.17.5301. PMC   332174 . PMID   2402465.
6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
7. "Entrez Gene: RPL17 ribosomal protein L17".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID   12761501. S2CID   38880905.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID   12962325. S2CID   10710245.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.

External links

• Overview of all the structural information available in the PDB for UniProt : P18621 (Human 60S ribosomal protein L17) at the PDBe-KB .