EIF1AY

EIF1AY
Identifiers
Aliases	EIF1AY , eIF-4C, eukaryotic translation initiation factor 1A, Y-linked, eukaryotic translation initiation factor 1A Y-linked
External IDs	OMIM: 400014 MGI: 1913485 HomoloGene: 100715 GeneCards: EIF1AY
Gene location (Human) Chr. Y chromosome (human) [1] Band Yq11.223 Start 20,575,776 bp [1] End 20,593,154 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X F4 Start 158,155,174 bp [2] End 158,172,924 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spongy bone vena cava rectum right lung seminal vesicula prostate Brodmann area 9 anterior pituitary urethra synovial joint Top expressed in otic placode saccule primitive streak hair follicle superior cervical ganglion medial ganglionic eminence maxillary prominence interventricular septum somite endocardial cushion More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 9086 66235 Ensembl ENSG00000198692 ENSMUSG00000067194 UniProt O14602 Q8BMJ3 RefSeq (mRNA) NM_004681 NM_001278612 NM_025437 RefSeq (protein) NP_001265541 NP_004672 NP_079713 Location (UCSC) Chr Y: 20.58 – 20.59 Mb Chr X: 158.16 – 158.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene. ^{[5] [6]}

Like its X-chromosomal counterpart EIF1AX, it encodes an isoform of eukaryotic translation initiation factor 1A (EIF1A). EIF1A is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. It has one amino acid difference (M50L) from EIF1AX. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000198692 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000067194 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lahn BT, Page DC (Nov 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID   9381176.
6. "Entrez Gene: EIF1AY eukaryotic translation initiation factor 1A, Y-linked".

Further reading

• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Fortna A, Kim Y, MacLaren E, et al. (2006). "Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution". PLOS Biol. 2 (7): E207. doi: 10.1371/journal.pbio.0020207 . PMC   449870 . PMID   15252450.
• Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. doi: 10.1093/molbev/msh027 . PMID   14660691.
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi: 10.1038/nature01722 . PMID   12815422.
• Marintchev A, Kolupaeva VG, Pestova TV, Wagner G (2003). "Mapping the binding interface between human eukaryotic initiation factors 1A and 5B: A new interaction between old partners". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 1535–40. Bibcode:2003PNAS..100.1535M. doi: 10.1073/pnas.0437845100 . PMC   149867 . PMID   12569173.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.