Mitochondrial ribosomal protein L37

MRPL37
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J7Y, 3J9M
Identifiers
Aliases	MRPL37 , L37mt, MRP-L2, MRP-L37, MRPL2, RPML2, mitochondrial ribosomal protein L37, L2mt
External IDs	OMIM: 611843 MGI: 1926268 HomoloGene: 9536 GeneCards: MRPL37
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p32.3 Start 54,184,041 bp [1] End 54,225,464 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 C7 Start 106,913,071 bp [2] End 106,924,065 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle Right adrenal gland tibialis anterior muscle left ventricle right lobe of liver Left adrenal gland quadriceps femoris muscle skeletal muscle tissue vastus lateralis muscle rectum Top expressed in lip skeletal muscle tissue triceps brachii muscle digastric muscle yolk sac temporal muscle proximal tubule interventricular septum soleus muscle sternocleidomastoid muscle More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrial ribosome mitochondrial large ribosomal subunit mitochondrion Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51253 56280 Ensembl ENSG00000116221 ENSMUSG00000028622 UniProt Q9BZE1 Q921S7 RefSeq (mRNA) NM_016491 NM_001330602 NM_025500 RefSeq (protein) NP_001317531 NP_057575 NP_079776 Location (UCSC) Chr 1: 54.18 – 54.23 Mb Chr 4: 106.91 – 106.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene. ^{[5] [6]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000116221 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028622 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Graack HR, Bryant ML, O'Brien TW (Jan 2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry. 38 (50): 16569–77. doi:10.1021/bi991543s. PMID   10600119.
6. "Entrez Gene: MRPL37 mitochondrial ribosomal protein L37".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Levshenkova EV, Ukraintsev KE, Orlova VV, et al. (2005). "[The structure and specific features of the cDNA expression of the human gene MRPL37]". Bioorg. Khim. 30 (5): 499–506. doi:10.1023/b:rubi.0000043788.86955.ea. PMID   15562971. S2CID   342310.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.

External links

• Overview of all the structural information available in the PDB for UniProt : Q9BZE1 (39S ribosomal protein L37, mitochondrial) at the PDBe-KB .