EIF2B4

EIF2B4
Identifiers
Aliases	EIF2B4 , EIF-2B, EIF2B, EIF2Bdelta, eukaryotic translation initiation factor 2B subunit delta
External IDs	OMIM: 606687; MGI: 95300; HomoloGene: 5976; GeneCards: EIF2B4; OMA:EIF2B4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p23.3 Start 27,364,352 bp [1] End 27,370,338 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B1 Start 31,344,902 bp [2] End 31,350,774 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas left testis right testis muscle layer of sigmoid colon sural nerve gingival epithelium anterior pituitary skin of abdomen mucosa of transverse colon skin of leg Top expressed in primitive streak temporal muscle primary oocyte digastric muscle hair follicle sternocleidomastoid muscle triceps brachii muscle muscle of thigh vastus lateralis muscle motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanyl-nucleotide exchange factor activity protein binding translation initiation factor binding translation initiation factor activity Cellular component cytoplasm cytosol eukaryotic translation initiation factor 2B complex Biological process response to peptide hormone response to heat response to glucose cell metabolism ovarian follicle development myelination oligodendrocyte development regulation of translation translational initiation protein biosynthesis T cell receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8890 13667 Ensembl ENSG00000115211 ENSMUSG00000029145 UniProt Q9UI10 Q61749 RefSeq (mRNA) NM_001034116 NM_015636 NM_172195 NM_001318965 NM_001318966 NM_001318967 NM_001318968 NM_001318969 NM_001127355 NM_001127356 NM_010122 RefSeq (protein) NP_001029288 NP_001305894 NP_001305895 NP_001305896 NP_001305897 NP_001305898 NP_056451 NP_751945 NP_001305896.1 NP_001120827 NP_001120828 NP_034252 Location (UCSC) Chr 2: 27.36 – 27.37 Mb Chr 5: 31.34 – 31.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Translation initiation factor eIF-2B subunit delta is a protein that in humans is encoded by the EIF2B4 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000115211 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029145 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Price NT, Mellor H, Craddock BL, Flowers KM, Kimball SR, Wilmer T, Jefferson LS, Proud CG (Nov 1996). "eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast". Biochem. J. 318 (2): 637–43. doi:10.1042/bj3180637. PMC   1217679 . PMID   8929216.
6. Henderson RA, Krissansen GW, Yong RY, Leung E, Watson JD, Dholakia JN (Dec 1994). "The delta-subunit of murine guanine nucleotide exchange factor eIF-2B. Characterization of cDNAs predicts isoforms differing at the amino-terminal end". J. Biol. Chem. 269 (48): 30517–23. doi: 10.1016/S0021-9258(18)43844-6 . PMID   7982969.
7. "Entrez Gene: EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa".

Further reading

• Welsh GI, Miyamoto S, Price NT, et al. (1996). "T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3". J. Biol. Chem. 271 (19): 11410–3. doi: 10.1074/jbc.271.19.11410 . PMID   8626696.
• Yang W, Hinnebusch AG (1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol. Cell. Biol. 16 (11): 6603–16. doi:10.1128/MCB.16.11.6603. PMC   231662 . PMID   8887689.
• Kimball SR, Heinzinger NK, Horetsky RL, Jefferson LS (1998). "Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B". J. Biol. Chem. 273 (5): 3039–44. doi: 10.1074/jbc.273.5.3039 . PMID   9446619.
• Gomez E, Pavitt GD (2000). "Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation". Mol. Cell. Biol. 20 (11): 3965–76. doi:10.1128/MCB.20.11.3965-3976.2000. PMC   85753 . PMID   10805739.
• Anthony TG, Fabian JR, Kimball SR, Jefferson LS (2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID   10858531.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Williams DD, Price NT, Loughlin AJ, Proud CG (2001). "Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein". J. Biol. Chem. 276 (27): 24697–703. doi: 10.1074/jbc.M011788200 . PMID   11323413.
• van der Knaap MS, Leegwater PA, Könst AA, et al. (2002). "Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter". Ann. Neurol. 51 (2): 264–70. doi:10.1002/ana.10112. PMID   11835386. S2CID   1849575.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Fogli A, Dionisi-Vici C, Deodato F, et al. (2003). "A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation". Neurology. 59 (12): 1966–8. doi:10.1212/01.wnl.0000041666.76863.47. PMID   12499492. S2CID   13129517.
• Kobayashi H, Børsheim E, Anthony TG, et al. (2003). "Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B". Am. J. Physiol. Endocrinol. Metab. 284 (3): E488–98. doi:10.1152/ajpendo.00094.2002. PMID   12556349.
• Fogli A, Rodriguez D, Eymard-Pierre E, et al. (2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations". Am. J. Hum. Genet. 72 (6): 1544–50. doi:10.1086/375404. PMC   1180314 . PMID   12707859.
• van der Knaap MS, van Berkel CG, Herms J, et al. (2004). "eIF2B-related disorders: antenatal onset and involvement of multiple organs". Am. J. Hum. Genet. 73 (5): 1199–207. doi:10.1086/379524. PMC   1180499 . PMID   14566705.
• Fogli A, Schiffmann R, Hugendubler L, et al. (2005). "Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients". Eur. J. Hum. Genet. 12 (7): 561–6. doi: 10.1038/sj.ejhg.5201189 . PMID   15054402.
• Li W, Wang X, Van Der Knaap MS, Proud CG (2004). "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways". Mol. Cell. Biol. 24 (8): 3295–306. doi:10.1128/MCB.24.8.3295-3306.2004. PMC   381664 . PMID   15060152.
• Van Haren K, van der Voorn JP, Peterson DR, et al. (2004). "The life and death of oligodendrocytes in vanishing white matter disease". J. Neuropathol. Exp. Neurol. 63 (6): 618–30. doi: 10.1093/jnen/63.6.618 . PMID   15217090.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Fogli A, Gauthier-Barichard F, Schiffmann R, et al. (2004). "Screening for known mutations in EIF2B genes in a large panel of patients with premature ovarian failure". BMC Women's Health. 4 (1): 8. doi: 10.1186/1472-6874-4-8 . PMC   529454 . PMID   15507143.