Mitochondrial ribosomal protein L17

Last updated
MRPL17
Protein MRPL17 PDB 2cqm.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPL17 , L17mt, LIP2, MRP-L17, MRP-L26, RPL17L, RPML26, mitochondrial ribosomal protein L17
External IDs OMIM: 611830; MGI: 1351608; HomoloGene: 32526; GeneCards: MRPL17; OMA:MRPL17 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022061

NM_025301

RefSeq (protein)

NP_071344

NP_079577

Location (UCSC) Chr 11: 6.68 – 6.68 Mb Chr 7: 105.45 – 105.46 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L17, mitochondrial is a protein that in humans is encoded by the MRPL17 gene. [5]

Contents

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000158042 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030879 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: MRPL17 mitochondrial ribosomal protein L17".

Further reading