MRPS35

Last updated
MRPS35
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPS35 , MDS023, MRP-S28, MRPS28, HDCMD11P, mitochondrial ribosomal protein S35
External IDs OMIM: 611995; MGI: 2385255; HomoloGene: 11048; GeneCards: MRPS35; OMA:MRPS35 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021821
NM_001190864

NM_145573

RefSeq (protein)

NP_001177793
NP_068593

NP_663548

Location (UCSC) Chr 12: 27.71 – 27.76 Mb Chr 6: 146.94 – 146.98 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S35, mitochondrial is a protein that in humans is encoded by the MRPS35 gene. [5] [6]

Contents

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000061794 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040112 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi: 10.1074/jbc.M100727200 . PMID   11279123.
  6. 1 2 "Entrez Gene: MRPS35 mitochondrial ribosomal protein S35".

Further reading