MRPS35

MRPS35
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Identifiers
Aliases	MRPS35 , MDS023, MRP-S28, MRPS28, HDCMD11P, mitochondrial ribosomal protein S35
External IDs	OMIM: 611995 MGI: 2385255 HomoloGene: 11048 GeneCards: MRPS35
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p11.22 Start 27,710,822 bp [1] End 27,756,295 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 G3 Start 147,042,764 bp [2] End 147,073,991 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural constituent of ribosome • RNA binding Cellular component • mitochondrial inner membrane • ribosome • mitochondrial small ribosomal subunit • mitochondrion Biological process • mitochondrial translational elongation • mitochondrial translational termination • DNA damage response, detection of DNA damage • mitochondrial translation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	60488	232536
Ensembl	ENSG00000061794	ENSMUSG00000040112
UniProt	P82673	Q8BJZ4
RefSeq (mRNA)	NM_021821 NM_001190864	NM_145573
RefSeq (protein)	NP_001177793 NP_068593	NP_663548
Location (UCSC)	Chr 12: 27.71 – 27.76 Mb	Chr 6: 147.04 – 147.07 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

28S ribosomal protein S35, mitochondrial is a protein that in humans is encoded by the MRPS35 gene. ^{[5] [6]}

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000061794 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040112 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi: 10.1074/jbc.M100727200 . PMID   11279123.
6. "Entrez Gene: MRPS35 mitochondrial ribosomal protein S35".

Further reading

• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ishiguchi H, Izumi H, Torigoe T, et al. (2004). "ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA". Int. J. Cancer. 111 (6): 900–9. doi:10.1002/ijc.20358. PMID   15300802. S2CID   37308382.
• Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID   12706105.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC   139241 . PMID   12477932.
• Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID   11543634.
• Koc EC, Burkhart W, Blackburn K, et al. (2001). "Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach". Protein Sci. 10 (3): 471–81. doi:10.1110/ps.35301. PMC   2374141 . PMID   11344316.

External links

• Overview of all the structural information available in the PDB for UniProt : P82673 (28S ribosomal protein S35, mitochondrial) at the PDBe-KB .