EIF3B

EIF3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KRB, 2NLW, 5K1H
Identifiers
Aliases	EIF3B , EIF3-ETA, EIF3-P110, EIF3-P116, EIF3S9, PRT1, eukaryotic translation initiation factor 3 subunit B
External IDs	OMIM: 603917 MGI: 106478 HomoloGene: 2780 GeneCards: EIF3B
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p22.3 Start 2,354,086 bp [1] End 2,380,745 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 G2|5 78.97 cM Start 140,405,083 bp [2] End 140,429,115 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas skin of abdomen stromal cell of endometrium left uterine tube gastrocnemius muscle smooth muscle tissue body of stomach parotid gland right uterine tube transverse colon Top expressed in spermatid yolk sac lip somite morula primitive streak maxillary prominence hair follicle lacrimal gland crypt of lieberkuhn of small intestine More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular adaptor activity translation initiation factor binding protein binding translation initiation factor activity nucleic acid binding RNA binding Cellular component cytosol eukaryotic translation initiation factor 3 complex eukaryotic translation initiation factor 3 complex, eIF3m extracellular exosome cytoplasm eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex synapse Biological process translational initiation IRES-dependent viral translational initiation protein biosynthesis viral translational termination-reinitiation regulation of translational initiation formation of cytoplasmic translation initiation complex cytoplasmic translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8662 27979 Ensembl ENSG00000106263 ENSMUSG00000056076 UniProt P55884 Q8JZQ9 RefSeq (mRNA) NM_001037283 NM_003751 NM_001362791 NM_001362792 NM_001362793 NM_182712 NM_133916 RefSeq (protein) NP_001032360 NP_003742 NP_001349720 NP_001349721 NP_001349722 NP_598677 Location (UCSC) Chr 7: 2.35 – 2.38 Mb Chr 5: 140.41 – 140.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 3 subunit B (eIF3b) is a protein that in humans is encoded by the EIF3B gene. ^{[5] [6]}

Interactions

EIF3B has been shown to interact with P70-S6 Kinase 1 ^[7] and EIF3A. ^{[5] [8] [9] [10]}

See also

• Eukaryotic initiation factor 3 (eIF3)

References

1. GRCh38: Ensembl release 89: ENSG00000106263 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056076 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Méthot N, Rom E, Olsen H, Sonenberg N (February 1997). "The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170". J. Biol. Chem. 272 (2): 1110–6. doi: 10.1074/jbc.272.2.1110 . PMID   8995410.
6. "Entrez Gene: EIF3S9 eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa".
7. Holz MK, Ballif BA, Gygi SP, Blenis J (November 2005). "mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events". Cell. 123 (4): 569–80. doi: 10.1016/j.cell.2005.10.024 . PMID   16286006. S2CID   11118504.
8. Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi: 10.1046/j.1432-1033.2003.03807.x . PMID   14519125.
9. Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC (April 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". EMBO J. 25 (8): 1659–68. doi:10.1038/sj.emboj.7601047. PMC   1440840 . PMID   16541103.
10. Block KL, Vornlocher HP, Hershey JW (November 1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi: 10.1074/jbc.273.48.31901 . PMID   9822659.

Further reading

• Kirken RA, Rui H, Evans GA, Farrar WL (1993). "Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit". J. Biol. Chem. 268 (30): 22765–70. doi: 10.1016/S0021-9258(18)41592-X . PMID   7693677.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Asano K, Kinzy TG, Merrick WC, Hershey JW (1997). "Conservation and diversity of eukaryotic translation initiation factor eIF3". J. Biol. Chem. 272 (2): 1101–9. doi: 10.1074/jbc.272.2.1101 . PMID   8995409.
• Chaudhuri J, Chakrabarti A, Maitra U (1997). "Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1". J. Biol. Chem. 272 (49): 30975–83. doi: 10.1074/jbc.272.49.30975 . PMID   9388245.
• Block KL, Vornlocher HP, Hershey JW (1998). "Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3". J. Biol. Chem. 273 (48): 31901–8. doi: 10.1074/jbc.273.48.31901 . PMID   9822659.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1998). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Lin L, Holbro T, Alonso G, Gerosa D, Burger MM (2001). "Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7". J. Cell. Biochem. 80 (4): 483–90. doi:10.1002/1097-4644(20010315)80:4<483::AID-JCB1002>3.0.CO;2-B. PMID   11169732. S2CID   35848129.
• Asano K, Shalev A, Phan L, Nielsen K, Clayton J, Valásek L, Donahue TF, Hinnebusch AG (2001). "Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation". EMBO J. 20 (9): 2326–37. doi:10.1093/emboj/20.9.2326. PMC   125443 . PMID   11331597.
• Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi: 10.1046/j.1432-1033.2003.03807.x . PMID   14519125.
• Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW (2004). "The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro". J. Biol. Chem. 279 (10): 8946–56. doi: 10.1074/jbc.M312745200 . PMID   14688252.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• ElAntak L, Tzakos AG, Locker N, Lukavsky PJ (2007). "Structure of eIF3b RNA recognition motif and its interaction with eIF3j: structural insights into the recruitment of eIF3b to the 40 S ribosomal subunit" (PDF). J. Biol. Chem. 282 (11): 8165–74. doi: 10.1074/jbc.M610860200 . PMID   17190833. S2CID   2313046.