Mitochondrial ribosomal protein L30

Last updated
MRPL30
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MRPL30 , L28MT, L30MT, MRP-L28, MRP-L30, MRPL28, MRPL28M, RPML28, mitochondrial ribosomal protein L30
External IDs OMIM: 611838; MGI: 1333820; HomoloGene: 32675; GeneCards: MRPL30; OMA:MRPL30 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016503
NM_145212
NM_145213

NM_027098
NM_001356482

RefSeq (protein)

NP_660213

NP_081374
NP_001343411

Location (UCSC) Chr 2: 99.18 – 99.2 Mb Chr 1: 37.93 – 37.94 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

39S ribosomal protein L30, mitochondrial is a protein that in humans is encoded by the MRPL30 gene. [5]

Contents

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified at least two transcript variants encoding the same protein. Pseudogenes corresponding to this gene are found on chromosomes 6p and 12p. [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000185414 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026087 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: MRPL30 mitochondrial ribosomal protein L30".

Further reading