EIF4A2

EIF4A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BOR
Identifiers
Aliases	EIF4A2 , BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II, eukaryotic translation initiation factor 4A2
External IDs	OMIM: 601102 MGI: 106906 HomoloGene: 1487 GeneCards: EIF4A2
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q27.3 Start 186,783,205 bp [1] End 186,789,897 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 B1|16 13.93 cM Start 22,926,194 bp [2] End 22,932,886 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell cerebellar vermis germinal epithelium postcentral gyrus superior frontal gyrus Region I of hippocampus proper Brodmann area 23 middle temporal gyrus pons Top expressed in diencephalon hypothalamus hippocampus proper cerebellar cortex superior frontal gyrus olfactory bulb uterus ovary mirror spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding translation initiation factor activity helicase activity protein binding nucleic acid binding hydrolase activity ATP binding ATPase activity RNA binding Cellular component cytosol perinuclear region of cytoplasm eukaryotic translation initiation factor 4F complex nucleolus Biological process nuclear-transcribed mRNA poly(A) tail shortening RNA secondary structure unwinding viral process negative regulation of RNA-directed 5'-3' RNA polymerase activity protein biosynthesis regulation of translational initiation translational initiation cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1974 13682 Ensembl ENSG00000156976 ENSMUSG00000022884 UniProt Q14240 P10630 RefSeq (mRNA) NM_001967 NM_001123037 NM_001123038 NM_013506 NM_001347179 RefSeq (protein) NP_001958 NP_001116509 NP_001116510 NP_001334108 NP_038534 Location (UCSC) Chr 3: 186.78 – 186.79 Mb Chr 16: 22.93 – 22.93 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000156976 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022884 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sudo K, Takahashi E, Nakamura Y (Jan 1996). "Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2". Cytogenet Cell Genet. 71 (4): 385–8. doi:10.1159/000134145. PMID   8521730.
6. "Entrez Gene: EIF4A2 eukaryotic translation initiation factor 4A, isoform 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Li W, Belsham GJ, Proud CG (2001). "Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo". J. Biol. Chem. 276 (31): 29111–5. doi: 10.1074/jbc.C100284200 . PMID   11408474.
• Kyono K, Miyashiro M, Taguchi I (2002). "Human eukaryotic initiation factor 4AII associates with hepatitis C virus NS5B protein in vitro". Biochem. Biophys. Res. Commun. 292 (3): 659–66. doi:10.1006/bbrc.2002.6702. PMID   11922617.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Sarkar M, Das S, Bandyopadhaya A, et al. (2005). "Upregulation of human mitochondrial NADH dehydrogenase subunit 5 in intestinal epithelial cells is modulated by Vibrio cholerae pathogenesis". FEBS Lett. 579 (16): 3449–60. doi: 10.1016/j.febslet.2005.05.012 . PMID   15946665. S2CID   25850943.
• Feng P, Everly DN, Read GS (2005). "mRNA Decay during Herpes Simplex Virus (HSV) Infections: Protein-Protein Interactions Involving the HSV Virion Host Shutoff Protein and Translation Factors eIF4H and eIF4A". J. Virol. 79 (15): 9651–64. doi:10.1128/JVI.79.15.9651-9664.2005. PMC   1181552 . PMID   16014927.
• Cheyssac C, Dina C, Leprêtre F, et al. (2006). "EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families". Diabetes. 55 (4): 1171–6. doi: 10.2337/diabetes.55.04.06.db05-1298 . PMID   16567544.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• Overview of all the structural information available in the PDB for UniProt : Q14240 (Human Eukaryotic initiation factor 4A-II (EIF4A2)) at the PDBe-KB .