EIF4E3

EIF4E3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4B6U, 4B6V
Identifiers
Aliases	EIF4E3 , eIF-4E3, eIF4E-3, eukaryotic translation initiation factor 4E family member 3
External IDs	OMIM: 609896 MGI: 1914142 HomoloGene: 41652 GeneCards: EIF4E3
Gene location (Human)
Chr.	Chromosome 3 (human)
End	71,754,773 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	99,666,771 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; monocyte; ; quadriceps femoris muscle; ; gastrocnemius muscle; ; vastus lateralis muscle; ; biceps brachii; ; secondary oocyte; ; blood; ; bone marrow;
	Top expressed in
	secondary oocyte; ; interventricular septum; ; brown adipose tissue; ; triceps brachii muscle; ; temporal muscle; ; myocardium of ventricle; ; vastus lateralis muscle; ; ankle; ; cardiac muscles; ; sternocleidomastoid muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation initiation factor activity ; RNA binding ; RNA 7-methylguanosine cap binding ;
Cellular component	cytoplasm ; cytosol ; mRNA cap binding complex ; eukaryotic translation initiation factor 4F complex ;
Biological process	translational initiation ; regulation of translation ; protein biosynthesis ;
	Sources:Amigo / QuickGO
Orthologs
	317649
	66892
	ENSG00000163412
	ENSMUSG00000093661
	Q8N5X7
	Q9DBB5
	NM_001134649 ; NM_001134650 ; NM_001134651 ; NM_001282886 ; NM_173359
	NM_025829
	NP_001128121 ; NP_001128122 ; NP_001128123 ; NP_001269815 ; NP_775495
	NP_080105
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 10, 2023

Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene.^[5]

EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome.^[5]^[6]

Related Research Articles

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene. The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template. Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.

Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.

Eukaryotic translation initiation factor 3 subunit H (eIF3h) is a protein that in humans is encoded by the EIF3H gene.

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.

Eukaryotic translation initiation factor 3 subunit D (eIF3d) is a protein that in humans is encoded by the EIF3D gene.

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene. It belongs to the eukaryotic translation initiation factor 4E family.

Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene.

Eukaryotic translation initiation factor 3 subunit J (eIF3j) is a protein that in humans is encoded by the EIF3J gene.

Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene.

Eukaryotic translation initiation factor 4E-binding protein 2 is a protein that in humans is encoded by the EIF4EBP2 gene.

Eukaryotic initiation factor 4A-II is a protein that in humans is encoded by the EIF4A2 gene.

Eukaryotic translation initiation factor 3 subunit K (eIF3k) is a protein that in humans is encoded by the EIF3K gene.

<span class="mw-page-title-main">EIF2AK4</span> Protein-coding gene in humans

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.

Eukaryotic translation initiation factor 3, subunit M (eIF3m) also known as PCI domain containing 1 (herpesvirus entry mediator) (PCID1), is a protein that in humans is encoded by the EIF3M gene.

Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene.

Eukaryotic translation initiation factor 1A, Y-chromosomal is a protein that in humans is encoded by the EIF1AY gene.

<span class="mw-page-title-main">EIF1B</span> Protein-coding gene in the species Homo sapiens

Eukaryotic translation initiation factor 1b is a protein that in humans is encoded by the EIF1B gene.

Eukaryotic translation initiation factor 4E family member 1B is a protein in humans that is encoded by the EIF4E1B gene.

Density regulated re-initiation and release factor (DENR) is a protein that in humans is encoded by the DENR gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163412 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000093661 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Eukaryotic translation initiation factor 4E family member 3" . Retrieved 2011-09-28.
↑ Joshi B, Cameron A, Jagus R (June 2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry. 271 (11): 2189–2203. doi: 10.1111/j.1432-1033.2004.04149.x . PMID 15153109.

External links

Overview of all the structural information available in the PDB for UniProt : Q9DBB5 (Mouse Eukaryotic translation initiation factor 4E type 3) at the PDBe-KB .

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163412 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000093661 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: Eukaryotic translation initiation factor 4E family member 3" . Retrieved 2011-09-28.

[6] Joshi B, Cameron A, Jagus R (June 2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry. 271 (11): 2189–2203. doi: 10.1111/j.1432-1033.2004.04149.x . PMID 15153109.

[1]

[2]

[3]

[4]

[5]

[6]