AUP1

AUP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EKF
Identifiers
Aliases	AUP1 , ancient ubiquitous protein 1, lipid droplet regulating VLDL assembly factor, AUP1 lipid droplet regulating VLDL assembly factor
External IDs	OMIM: 602434 MGI: 107789 HomoloGene: 7239 GeneCards: AUP1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,529,760 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,034,789 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; body of stomach; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; spleen; ; right lobe of liver; ; minor salivary gland; ; canal of the cervix; ; anterior pituitary; ; upper lobe of left lung;
	Top expressed in
	proximal tubule; ; yolk sac; ; lip; ; superior frontal gyrus; ; spermatocyte; ; crypt of lieberkuhn of small intestine; ; duodenum; ; left lobe of liver; ; blood; ; kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin binding ; ubiquitin-protein transferase activator activity ; protein binding ;
Cellular component	extracellular exosome ; endoplasmic reticulum membrane ; membrane ; integral component of endoplasmic reticulum membrane ; Hrd1p ubiquitin ligase ERAD-L complex ; integral component of membrane ; endoplasmic reticulum ;
Biological process	retrograde protein transport, ER to cytosol ; ubiquitin-dependent ERAD pathway ; regulation of catalytic activity ;
	Sources:Amigo / QuickGO
Orthologs
	550
	11993
	ENSG00000115307
	ENSMUSG00000068328
	Q9Y679
	P70295
	NM_181575
	NM_001025446 ; NM_001301649 ; NM_007517
	NP_853553
	NP_001288578 ; NP_031543
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 16, 2023

Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.^[5]^[6]^[7]

Function

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha (IIb) subunits. These subunits play a crucial role in the integrin alpha (IIb) beta (3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.^[7]

Interactions

AUP1 has been shown to interact with ITGA2B.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115307 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068328 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jang W, Weber JS, Bashir R, Bushby K, Meisler MH (Jan 1997). "Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13". Genomics. 36 (2): 366–8. doi:10.1006/geno.1996.0477. PMID 8812468.
1 2 Kato A, Kawamata N, Tamayose K, Egashira M, Miura R, Fujimura T, Murayama K, Oshimi K (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J Biol Chem. 277 (32): 28934–41. doi: 10.1074/jbc.M204340200 . PMID 12042322.
1 2 "Entrez Gene: AUP1 ancient ubiquitous protein 1".

External links

Human AUP1 genome location and AUP1 gene details page in the UCSC Genome Browser .
Overview of all the structural information available in the PDB for UniProt : Q9Y679 (Ancient ubiquitous protein 1) at the PDBe-KB .