AUP1

AUP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EKF
Identifiers
Aliases	AUP1 , ancient ubiquitous protein 1, lipid droplet regulating VLDL assembly factor, AUP1 lipid droplet regulating VLDL assembly factor
External IDs	OMIM: 602434; MGI: 107789; HomoloGene: 7239; GeneCards: AUP1; OMA:AUP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p13.1 Start 74,526,645 bp [1] End 74,529,760 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 C3|6 35.94 cM Start 83,031,502 bp [2] End 83,034,789 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte body of pancreas mucosa of transverse colon body of stomach left lobe of thyroid gland right lobe of thyroid gland tendon of biceps brachii spleen right lobe of liver minor salivary glands Top expressed in right kidney granulocyte muscle of thigh proximal tubule choroid plexus of fourth ventricle yolk sac neural layer of retina lip superior frontal gyrus primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin binding ubiquitin-protein transferase activator activity protein binding Cellular component extracellular exosome endoplasmic reticulum membrane membrane integral component of endoplasmic reticulum membrane Hrd1p ubiquitin ligase ERAD-L complex integral component of membrane endoplasmic reticulum Biological process retrograde protein transport, ER to cytosol ubiquitin-dependent ERAD pathway regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 550 11993 Ensembl ENSG00000115307 ENSMUSG00000068328 UniProt Q9Y679 P70295 RefSeq (mRNA) NM_181575 NM_001025446 NM_001301649 NM_007517 RefSeq (protein) NP_853553 NP_001288578 NP_031543 Location (UCSC) Chr 2: 74.53 – 74.53 Mb Chr 6: 83.03 – 83.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene. ^{[5] [6] [7]}

Function

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha (IIb) subunits. These subunits play a crucial role in the integrin alpha (IIb) beta (3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25. ^[7]

Interactions

AUP1 has been shown to interact with ITGA2B. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000115307 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068328 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jang W, Weber JS, Bashir R, Bushby K, Meisler MH (Jan 1997). "Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13". Genomics. 36 (2): 366–8. doi:10.1006/geno.1996.0477. PMID   8812468.
6. Kato A, Kawamata N, Tamayose K, Egashira M, Miura R, Fujimura T, Murayama K, Oshimi K (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J Biol Chem. 277 (32): 28934–41. doi: 10.1074/jbc.M204340200 . PMID   12042322.
7. "Entrez Gene: AUP1 ancient ubiquitous protein 1".

External links

• Human AUP1 genome location and AUP1 gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : Q9Y679 (Ancient ubiquitous protein 1) at the PDBe-KB .

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Karpisheva KV, Tauber B, Kisliakova TV, Dobner T (2003). "[A new human cellular protein AUP1. III. The intracellular localization of AUP1 protein in different human and rat cell lines]". Tsitologiia. 44 (9): 846–51. PMID   12534238.
• Karpisheva KV, Touber B, Kisliakova TV, Dobner T (2003). "[A new human cellular protein AUP1. II. cDNA cloning, genomic organization of Aup1 gene ans [sic] preliminary characterization of human AUP1 protein]". Tsitologiia. 44 (9): 839–45. PMID   12534237.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.