Names | |
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Preferred IUPAC name 4-Isothiocyanato-N-(4-nitrophenyl)aniline | |
Other names 4-Isothiocyanato-4′-nitrodiphenylamine Nithiocyamine | |
Identifiers | |
3D model (JSmol) | |
ChEBI | |
ChEMBL | |
ChemSpider | |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C13H9N3O2S | |
Molar mass | 271.29 g·mol−1 |
Melting point | 204 to 206 °C (399 to 403 °F; 477 to 479 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Amoscanate (INN), also known as nithiocyamine, is an experimental anthelmintic agent of the aryl isothiocyanate class which was found to be highly effective in animals against the four major species of schistosomes which infect humans, [1] and is also highly active against hookworm infection. [2] [3] However, significant liver toxicity was seen in lab animals at higher doses. The ether analogue of amoscanate, nitroscanate, is used in veterinary medicine as an anthelmintic.[ citation needed ]
Scrub typhus or bush typhus is a form of typhus caused by the intracellular parasite Orientia tsutsugamushi, a Gram-negative α-proteobacterium of family Rickettsiaceae first isolated and identified in 1930 in Japan.
Hymenolepiasis is infestation by one of two species of tapeworm: Hymenolepis nana or H. diminuta. Alternative names are dwarf tapeworm infection and rat tapeworm infection. The disease is a type of helminthiasis which is classified as a neglected tropical disease.
Fasciolopsiasis results from an infection by the trematode Fasciolopsis buski, the largest intestinal fluke of humans, growing up to 7.5 cm (3.0 in) long.
Hookworm infection is an infection by a type of intestinal parasite known as a hookworm. Initially, itching and a rash may occur at the site of infection. Those only affected by a few worms may show no symptoms. Those infected by many worms may experience abdominal pain, diarrhea, weight loss, and tiredness. The mental and physical development of children may be affected. Anemia may result.
Eosinophiluria is the abnormal presence of eosinophils in the urine. It can be measured by detecting levels of eosinophil cationic protein.
Plasmodium chabaudi is a parasite of the genus Plasmodium subgenus Vinckeia. As in all Plasmodium species, P. chabaudi has both vertebrate and insect hosts. The vertebrate hosts for this parasite are rodents.
8-Aminoquinoline is the 8-amino derivative of quinoline. Often abbreviated AQ, it is a pale yellow solid. It is structurally analogous to 8-hydroxyquinoline.
Bartonella bacilliformis is a bacterium, Gram negative aerobic, pleomorphic, flagellated, motile, coccobacillary, 2–3 μm long, 0.2–0.5 μm wide, and a facultative intracellular bacterium.
Protionamide is a drug used in the treatment of tuberculosis and leprosy.
Carbarsone is an organoarsenic compound used as an antiprotozoal drug for treatment of amebiasis and other infections. It was available for amebiasis in the United States as late as 1991. Thereafter, it remained available as a turkey feed additive for increasing weight gain and controlling histomoniasis.
Dhori virus (DHOV) is a species of the genus Thogotovirus and a member of the family Orthomyxoviridae. Its host is most commonly Ixodidae ticks but can also be other species of ticks, mosquitoes, and mammals. DHOV is lethal to mice, leads to high rates of miscarriages in sheep and goats, and causes systemic pathologic changes similar to those reported in humans with virulent influenza A (H5N1) virus infection.
The Kato technique is a laboratory method for preparing human stool samples prior to searching for parasite eggs.
Oesophagostomum is a genus of parasitic nematodes (roundworms) of the family Strongylidae. These worms occur in Africa, Brazil, China, Indonesia and the Philippines. The majority of human infection with Oesophagostomum is localized to northern Togo and Ghana. Because the eggs may be indistinguishable from those of the hookworms, the species causing human helminthomas are rarely identified with accuracy. Oesophagostomum, especially O. bifurcum, are common parasites of livestock and animals like goats, pigs and non-human primates, although it seems that humans are increasingly becoming favorable hosts as well. The disease they cause, oesophagostomiasis, is known for the nodule formation it causes in the intestines of its infected hosts, which can lead to more serious problems such as dysentery. Although the routes of human infection have yet to be elucidated sufficiently, it is believed that transmission occurs through oral-fecal means, with infected humans unknowingly ingesting soil containing the infectious filariform larvae.
Brugia timori is a filarial (arthropod-borne) nematode (roundworm) which causes the disease "Timor filariasis", or "Timorian filariasis". While this disease was first described in 1965, the identity of Brugia timori as the causative agent was not known until 1977. In that same year, Anopheles barbirostris was shown to be its primary vector. There is no known animal reservoir host.
Fyodor Alexandrovich Lesh, alternatively spelled as Lösch, was a Russian medical doctor.
The Mazzotti reaction, first described in 1948, is a symptom complex seen in patients after undergoing treatment of nematode infestation, particularly with the medication diethylcarbamazine (DEC). Mazzotti reactions can be life-threatening, and are characterized by fever, urticaria, swollen and tender lymph nodes, tachycardia, hypotension, arthralgias, oedema, and abdominal pain that occur within seven days of treatment of microfilariasis. The Mazzotti reaction correlates with intensity of infection; however, there are probably multiple infection intensity-dependent mechanisms responsible for mediating this complex reaction.
Tete orthobunyavirus is a bunyavirus found originally in Tete Province, Mozambique. It is a disease of animals and humans. Two forms, Bahig and Matruh viruses, were isolated from bird ticks including Hyalomma marginatum, but elsewhere mosquitoes and biting midges have been implicated as vectors.
Cryptosporidium muris is a species of coccidium, first isolated from the gastric glands of the common mouse. Cryptosporidium does originate in common mice, specifically laboratory mice. However, it also has infected cows, dogs, cats, rats, rabbits, lambs, and humans and other primates.
Tensaw orthobunyavirus is a virus in the genus Orthobunyavirus of the Bunyamwera arbovirus group, order Bunyavirales. It is named for the river bordering the area in south Alabama where the prototype strain was discovered. It is abbreviated TEN, TENV, and TSV in the scientific literature.
Haemaphysalis spinigera, is a hard-bodied tick of the genus Haemaphysalis. It is found in India, Sri Lanka, Vietnam. It is an obligate ectoparasite of mammals of various rodents, insectivores and monkeys. It is a potential vector of Kyasanur Forest disease virus, and Kaisodi virus.