Angiomotin-like protein 1

AMOTL1
Identifiers
Aliases	AMOTL1 , JEAP, angiomotin like 1
External IDs	OMIM: 614657 MGI: 1922973 HomoloGene: 43977 GeneCards: AMOTL1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	94,876,748 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	14,556,352 bp
RNA expression pattern
	Top expressed in
	quadriceps femoris muscle; ; deltoid muscle; ; gastrocnemius muscle; ; vastus lateralis muscle; ; retinal pigment epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:0001948 protein binding ; identical protein binding ;
Cellular component	COP9 signalosome ; cytosol ; apical plasma membrane ; GO:0016023 cytoplasmic vesicle ; lamellipodium ; bicellular tight junction ; cell junction ;
Biological process	establishment of cell polarity involved in ameboidal cell migration ; Wnt signaling pathway ; hippo signaling ; positive regulation of blood vessel endothelial cell migration ; actin cytoskeleton organization ; regulation of cell migration ; angiogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	154810
	75723
	ENSG00000166025
	ENSMUSG00000013076
	Q8IY63
	Q9D4H4
	NM_001301007 ; NM_130847
	NM_001081395
	NP_001287936 ; NP_570899 ; NP_570899.1
	NP_001074864
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2022

Angiomotin-like protein 1 is a protein that in humans is encoded by the AMOTL1 gene.^[5]^[6]

Function

The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation.^[6]

Related Research Articles

Angiomotin (AMOT) is a protein that in humans is encoded by the AMOT gene. It belongs to the motin family of angiostatin binding proteins, which includes angiomotin, angiomotin-like 1 (AMOTL1) and angiomotin-like 2 (AMOTL2) characterized by coiled-coil domains at N-terminus and consensus PDZ-binding domain at the C-terminus. Angiomotin is expressed predominantly in endothelial cells of capillaries as well as angiogenic tissues such as placenta and solid tumor.

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Claudin-8 is a protein that in humans is encoded by the CLDN8 gene. It belongs to the group of claudins.

Zinc finger protein 593 is a protein that in humans is encoded by the ZNF593 gene.

Calcium-binding and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the CALCOCO1 gene.

TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene.

Trafficking kinesin-binding protein 1 is a protein that in humans is encoded by the TRAK1 gene.

Claudin-14 is a protein that in humans is encoded by the CLDN14 gene. It belongs to a related family of proteins called claudins.

RING finger protein 38 is a protein that in humans is encoded by the RNF38 gene.

LIM/homeobox protein Lhx6 is a protein that in humans is encoded by the LHX6 gene.

Coiled-coil domain-containing protein 55 is a protein that in humans is encoded by the CCDC55 gene.

Endothelial cell-selective adhesion molecule is a protein that in humans is encoded by the ESAM gene.

Zinc finger protein 346 is a protein that in humans is encoded by the ZNF346 gene.

Angiomotin-like protein 2 is a protein that in humans is encoded by the AMOTL2 gene.

Polyamine-modulated factor 1-binding protein 1 is a protein that is encoded in humans by the PMFBP1 gene.

Coiled-coil domain-containing protein 3 is a protein that in humans is encoded by the CCDC3 gene.

Tripartite motif-containing protein 15 is a protein that in humans is encoded by the TRIM15 gene.

Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.

High mobility group nucleosome-binding domain-containing protein 4 is a transcription factor that in humans is encoded by the HMGN4 gene.

Espin, also known as autosomal recessive deafness type 36 protein or ectoplasmic specialization protein, is a protein that in humans is encoded by the ESPN gene. Espin is a microfilament binding protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166025 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013076 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y (Feb 2002). "JEAP, a novel component of tight junctions in exocrine cells". J Biol Chem. 277 (7): 5583–7. doi: 10.1074/jbc.M110154200 . PMID 11733531.
1 2 "Entrez Gene: AMOTL1 angiomotin like 1".

External links

Human AMOTL1 genome location and AMOTL1 gene details page in the UCSC Genome Browser .

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Bratt A, Wilson WJ, Troyanovsky B, et al. (2003). "Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains". Gene. 298 (1): 69–77. doi:10.1016/S0378-1119(02)00928-9. PMID 12406577.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Patrie KM (2005). "Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1". Biochim. Biophys. Acta. 1745 (1): 131–44. doi: 10.1016/j.bbamcr.2005.05.011 . PMID 16019084.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166025 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000013076 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11733531-5] Nishimura M, Kakizaki M, Ono Y, Morimoto K, Takeuchi M, Inoue Y, Imai T, Takai Y (Feb 2002). "JEAP, a novel component of tight junctions in exocrine cells". J Biol Chem. 277 (7): 5583–7. doi: 10.1074/jbc.M110154200 . PMID 11733531.

[entrez-6] 1 2 "Entrez Gene: AMOTL1 angiomotin like 1".

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Angiomotin-like protein 1

Contents

Function

Related Research Articles

References

External links

Further reading