Antiviral protein

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Mechanism of zinc-finger antiviral protein (ZAP) recognition of specific target RNA, and the process by which ZAP coordinates downstream RNA degradation (left). ZAP-RNA complex protein ribbon diagram (right). 1-s2.0-S2211124719316390-fx1 lrg.jpg
Mechanism of zinc-finger antiviral protein (ZAP) recognition of specific target RNA, and the process by which ZAP coordinates downstream RNA degradation (left). ZAP-RNA complex protein ribbon diagram (right).

Antiviral proteins are proteins that are induced by human or animal cells to interfere with viral replication. These proteins are isolated to inhibit the virus from replicating in a host's cells and stop it from spreading to other cells.[ citation needed ] The Pokeweed antiviral protein and the Zinc-Finger antiviral protein are two major antiviral proteins that have undergone several tests for viruses, including HIV and influenza.[ citation needed ]

Contents

Pokeweed antiviral protein

Pokeweed antiviral protein is a ribosome inactivating protein that provides pokeweed plants protection against both viral and fungal infections. [1] It also protects other types of plants that have genetically engineered to express RAP that do not normally do so. [1] Recombinant pokeweed antiviral protein has also been proposed as a treatment of human diseases such as AIDS and cancer. [2] [3]

ZC3HAV1

ZAP (Zinc finger Antiviral Protein) is encoded by the ZC3HAV1 gene in humans [4] whose expression is induced by interferon and helps fight a number of viral infections including influenza. [5]

RNase L

Ribonuclease L or RNase L (for latent), ais an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell (both cellular and viral) as well as inhibiting mRNA export. [6] [7] RNase L is an enzyme that in humans is encoded by the RNASEL gene in humans.

IFITM3

Interferon-induced transmembrane protein 3 (IFITM3) inhibits the replication of number of enveloped RNA viruses including influenza A, HIV and the Ebola and Dengue viruses. [8] Consequently pharmacological induction of IFITM3 potentially could be used to treat a number of viral infections. [5]

Protein kinase R

Protein kinase R is interferon stimulated and activated either by double-stranded RNA (occurring as an intermediate in RNA viruses replication) or by other proteins. It is able to phosphorylate the eukaryotic translation initiation factor eIF2α thus inhibiting further cellular mRNA translation. [9]

References

  1. 1 2 Di R, Tumer NE (March 2015). "Pokeweed antiviral protein: its cytotoxicity mechanism and applications in plant disease resistance". Toxins. 7 (3): 755–72. doi: 10.3390/toxins7030755 . PMC   4379523 . PMID   25756953.
  2. ↑ Rajamohan F, Engstrom CR, Denton TJ, Engen LA, Kourinov I, Uckun FM (July 1999). "High-level expression and purification of biologically active recombinant pokeweed antiviral protein". Protein Expression and Purification. 16 (2): 359–68. doi:10.1006/prep.1999.1084. PMID   10419833.
  3. ↑ Uckun FM, Rajamohan F, Pendergrass S, Ozer Z, Waurzyniak B, Mao C (March 2003). "Structure-based design and engineering of a nontoxic recombinant pokeweed antiviral protein with potent anti-human immunodeficiency virus activity". Antimicrobial Agents and Chemotherapy. 47 (3): 1052–61. doi:10.1128/aac.47.3.1052-1061.2003. PMC   149289 . PMID   12604541.
  4. ↑ Gupte R, Liu Z, Kraus WL (January 2017). "PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes". Genes & Development. 31 (2): 101–126. doi:10.1101/gad.291518.116. PMC   5322727 . PMID   28202539.
  5. 1 2 Bedford JG, O'Keeffe M, Reading PC, Wakim LM (2019). "Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection". PLOS ONE. 14 (1): e0210132. Bibcode:2019PLoSO..1410132B. doi: 10.1371/journal.pone.0210132 . PMC   6334895 . PMID   30650117.
  6. ↑ Brennan-Laun, Sarah E.; Ezelle, Heather J.; Li, Xiao-Ling; Hassel, Bret A. (April 2014). "RNase-L Control of Cellular mRNAs: Roles in Biologic Functions and Mechanisms of Substrate Targeting". Journal of Interferon & Cytokine Research. 34 (4): 275–288. doi:10.1089/jir.2013.0147. ISSN   1079-9907. PMC   3976596 . PMID   24697205.
  7. ↑ Burke, James M.; Gilchrist, Alison R.; Sawyer, Sara L.; Parker, Roy (2021-06-04). "RNase L limits host and viral protein synthesis via inhibition of mRNA export". Science Advances. 7 (23). doi:10.1126/sciadv.abh2479. ISSN   2375-2548. PMC   8177694 . PMID   34088676.
  8. ↑ Wellington D, Laurenson-Schafer H, Abdel-Haq A, Dong T (February 2019). "IFITM3: How genetics influence influenza infection demographically". Biomedical Journal. 42 (1): 19–26. doi:10.1016/j.bj.2019.01.004. PMC   6468115 . PMID   30987701.
  9. ↑ Fensterl, V.; Sen, G. C. (2009), "Interferons and viral infections", BioFactors, 35 (1): 14–20, doi:10.1002/biof.6, PMID   19319841, S2CID   27209861
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