Highway 43 is a designation for three north–south state highways in Arkansas. One segment of 27.1 miles (43.6 km) runs from Highway 264 in Siloam Springs north into Delaware County, Oklahoma along Oklahoma State Highway 20 (SH-20) to terminate at Missouri Route 43 (Route 43) at the Missouri/Oklahoma/Arkansas tri-point near Southwest City, Missouri. A second segment of 20.0 miles (32.2 km) runs northeast from Highway 21 at Boxley to Highway 7 in Harrison. The third segment runs 1.8 miles (2.9 km) north in Harrison from US Route 65 (US 65) to Highway 7.
Highway 99 is a former north–south state highway in Arkansas. Created in 1926, the route connected several small communities in the northwest corner of the state near the Oklahoma border. The highway briefly overlapped with Oklahoma State Highway 20 (SH-20) along the state line, and the two routes briefly enter Oklahoma together. It was significantly shortened in the 1930s, and fully replaced by the Highway 43 designation in 1971. The route was maintained by the Arkansas State Highway and Transportation Department (AHTD), except where the designation entered Oklahoma, where it was maintained by the Oklahoma Department of Highways.
Highway 41 is a designation for two state highways in Western Arkansas. One route of 18.02 miles (29.00 km) runs from Franklin County Route 40 (CR 40) south to Highway 23 near Chismville. A second routing begins at US Route 70B (US 70B) in De Queen and runs south to Texas State Highway 8 at the Texas state line. The northern segment of Highway 41 contains a 0.60 miles (0.97 km) officially designated exception over Highway 22 in Branch.
Highway 102 is an east–west state highway in Benton County, Arkansas. The highway connects two of western Benton County's population centers to Bentonville and Interstate 49 (I-49), the main north-south route in the Northwest Arkansas region.
Highway 87 is a designation for four north–south state highways in Arkansas. Created during the 1926 Arkansas state highway numbering, the original alignment remains between Bradford and Pleasant Plains, though it has been revised and extended over the years. The three remaining segments are former county roads, connecting rural communities to local points of interest and other state highways. All three were added to the state highway system in 1973 during a period of system expansion. All segments are maintained by the Arkansas Department of Transportation (ArDOT).
Highway 103 is a designation for two north–south state highways in Arkansas. One segment begins in Clarksville in the Arkansas River Valley and runs north to the Ozark National Forest. A second route runs through a sparsely populated segment of the Ozark Mountains between the Buffalo National River and Highway 21 near the Missouri state line.
Highway 77 is a north–south state highway in Northeast Arkansas. The route of 66.70 miles (107.34 km) runs from US Highway 70 (US 70) in West Memphis north through small towns and agricultural areas of the Arkansas Delta to the Missouri state line. It is generally a low-traffic road except in West Memphis. Created during the 1926 Arkansas state highway numbering, the route was extended in the 1950s and 1960s, including along a former alignment of US 61. AR 77 does not have any spur or business routes.
Highway 14 is an east–west state highway in Arkansas. The route of 227.35 miles (365.88 km) begins at Boat Dock Road near Table Rock Lake and runs east to Mississippi County Route W1020 (CR W1020) at Golden Lake. Segments of the highway are part of two Arkansas Scenic Byways: Sylamore Scenic Byway in the Ozark National Forest and the Crowley's Ridge Parkway atop Crowley's Ridge.
Highway 123 is a designation for two state highways in Arkansas. One route begins at Salmon Lane in Boone County and runs 1.63 miles (2.62 km) north to US Highway 65 Business (US 65B) in Harrison. A second route begins at Highway 103 in Clarksville and runs 67.74 miles (109.02 km) northeast to US 65 and US 65B in Western Grove. A suffixed route, designated Highway 123Y runs near Lurton, giving non-truck travelers access to Highway 7. All three routes are maintained by the Arkansas Department of Transportation (ArDOT).
Highway 115 is a state highway in Northeast Arkansas. The route begins at US Highway 167 and Highway 58 in Cave City and runs northeast to Missouri Route 21 near Doniphan, Missouri, including a 14 miles (23 km) concurrency with US 62/US 412 between Imboden and Pocahontas. The highway is maintained by the Arkansas Department of Transportation (ARDOT).
Arkansas Highway 119 is a series of state highways that run in Northeast Arkansas. All routes are maintained by the Arkansas Department of Transportation (ArDOT).
Highway 18 is an east–west state highway of 93.43 miles (150.36 km) in Northeast Arkansas.
Highway 120 is an east–west state highway in Mississippi County, Arkansas. The route begins at US Highway 61 (US 61) and the Great River Road at Tuckertown and runs 8.03 miles (12.92 km) east to CR 903 at O'Donnell Bend at a levee along the Mississippi River. The route is maintained by the Arkansas Department of Transportation (ArDOT).
Highway 164 is a designation for four segments of state highway in the Arkansas River Valley. Each are low-volume local roads providing connectivity to small communities, or recreation areas near the Ozark National Forest. The first segment was created in 1945, with the remaining segments created during the late 1950s and 1960s, a period of major Arkansas Highway System expansion. A single spur route provides access to an industrial area in Clarksville. All routes are maintained by the Arkansas Department of Transportation (ArDOT).
Three auxiliary routes of Arkansas Highway 18 exist in Northeast Arkansas, with one former alignment.
Highway 75 is a north–south state highway in the Arkansas Delta. The route runs from Highway 38/Highway 50 north to Interstate 555/AR 14 in Marked Tree. Created during the initial 1926 Arkansas state highway numbering, Highway 75 has been shortened and extended over roughly the same alignment over its lifetime. The highway has one spur route, Highway 75 Spur in the small town of Parkin. Both highways are maintained by the Arkansas Department of Transportation (ArDOT).
Highway 52 is a designation for three state highways in Southeast Arkansas. All segments are low volume, two-lane roadways in rural areas. The segment between Wilmot and Indian has been designated since the original 1926 Arkansas state highway numbering, with new designations created in 1966 and 1985. All segments are maintained by the Arkansas Department of Transportation (ArDOT).
Highway 144 is a designation for two state highways in Southeast Arkansas. One route of 7.82 miles (12.59 km) begins at Big Bayou Meto Use Area and runs east to US Highway 165 (US 165), Highway 1, and the Great River Road (GRR). A second route of 20.50 miles (32.99 km) begins at US 165 near Jerome and runs east through Lake Village to a levee near the Mississippi River. Both routes are maintained by the Arkansas Department of Transportation (ArDOT). While overlapping US 65/US 278 in Chicot County, the route is part of the Great River Road, a national scenic byway following the Mississippi River.
Highway 130 is an east–west state highway in Arkansas County, Arkansas. Mostly a low-volume, two-lane road, Highway 130 connects the two county seats of Arkansas County, Stuttgart and DeWitt. The highway began as State Road 30, one of the original state highways in 1926 between North Little Rock and DeWitt. It was renumbered to 130 to prevent confusion with Interstate 30 in 1958, and the segment between North Little Rock and Stuttgart was replaced by an extension of US 165 in 1981, producing the current alignment. Highway 130 has one spur route in Almyra, and a former alternate route in DeWitt that was designated but never built. The routes are maintained by the Arkansas Department of Transportation (ARDOT).
Highway 42 is an east–west state highway of 53.69 miles (86.41 km) in Northeast Arkansas. The highways begins in the corn and cotton fields of the Mississippi Alluvial Plain at Highway 37, crosses the Crowley's Ridge and ends in the St. Francis Lowlands. The highway is a rural, two-lane road with relatively low traffic serving a sparsely populated agricultural area of Arkansas. Highway 42 is one of the original state highways created during the 1926 Arkansas state highway numbering, and has remained largely unchanged since bridge construction and an eastward extension in 1938. It is maintained by the Arkansas Department of Transportation (ARDOT).
US 61 / Great River Road 
