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Psoriasis is a long-lasting, noncontagious autoimmune disease characterized by patches of abnormal skin. These areas are red, pink, or purple, dry, itchy, and scaly. Psoriasis varies in severity from small localized patches to complete body coverage. Injury to the skin can trigger psoriatic skin changes at that spot, which is known as the Koebner phenomenon.
Adapalene is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. Studies have found adapalene is as effective as other retinoids, while causing less irritation. It also has several advantages over other retinoids. The adapalene molecule is more stable compared to tretinoin and tazarotene, which leads to less concern for photodegradation. It is also chemically more stable compared to the other two retinoids, allowing it to be used in combination with benzoyl peroxide. Due to its effects on keratinocyte proliferation and differentiation, adapalene is superior to tretinoin for the treatment of comedonal acne and is often used as a first-line agent. The Swiss company Galderma sells adapalene under the brand-name product Differin.
Darier's disease (DAR) is an inherited skin disorder that presents with multiple greasy, crusting, thick brown bumps that merge into patches. It is an autosomal dominant disorder discovered by French dermatologist Ferdinand-Jean Darier.
Pityriasis rosea is a type of skin rash. Classically, it begins with a single red and slightly scaly area known as a "herald patch". This is then followed, days to weeks later, by an eruption of many smaller scaly spots; pinkish with a red edge in people with light skin and greyish in darker skin. About 20% of cases show atypical deviations from this pattern. It usually lasts less than three months and goes away without treatment. Sometimes malaise or a fever may occur before the start of the rash or itchiness, but often there are few other symptoms.
Ferdinand-Jean Darier was a French physician, pathologist and dermatologist called the "father of modern dermatology in France".
Actinic keratosis (AK), sometimes called solar keratosis or senile keratosis, is a pre-cancerous area of thick, scaly, or crusty skin. Actinic keratosis is a disorder of epidermal keratinocytes that is induced by ultraviolet (UV) light exposure. These growths are more common in fair-skinned people and those who are frequently in the sun. They are believed to form when skin gets damaged by UV radiation from the sun or indoor tanning beds, usually over the course of decades. Given their pre-cancerous nature, if left untreated, they may turn into a type of skin cancer called squamous cell carcinoma. Untreated lesions have up to a 20% risk of progression to squamous cell carcinoma, so treatment by a dermatologist is recommended.
Palmoplantar keratodermas are a heterogeneous group of disorders characterized by abnormal thickening of the stratum corneum of the palms and soles.
Grenz rays are part of the electromagnetic spectrum comprising low energy (ultrasoft) X-rays. These were first investigated by Gustav Bucky in 1923 using a cathode vacuum tube with a lithium borate glass window, which he labeled Grenz rays as he believed that the biological effects resembled those of UV light and traditional X-rays and hence were on the border between the two. These rays are also known as Bucky rays.
The Koebner phenomenon or Köbner phenomenon, also called the Koebner response or the isomorphic response, attributed to Heinrich Köbner, is the appearance of skin lesions on lines of trauma. The Koebner phenomenon may result from either a linear exposure or irritation. Conditions demonstrating linear lesions after a linear exposure to a causative agent include: molluscum contagiosum, warts and toxicodendron dermatitis. Warts and molluscum contagiosum lesions can be spread in linear patterns by self-scratching ("auto-inoculation"). Toxicodendron dermatitis lesions are often linear from brushing up against the plant. Causes of the Koebner phenomenon that are secondary to scratching rather than an infective or chemical cause include vitiligo, psoriasis, lichen planus, lichen nitidus, pityriasis rubra pilaris, and keratosis follicularis.
Psychodermatology is the treatment of skin disorders using psychological and psychiatric techniques by addressing the interaction between mind and skin. Though historically there has not been strong scientific support for its practice, there is increasing evidence that behavioral treatments may be effective in the management of chronic skin disorders.
Cutaneous horns, also known by the Latin name cornu cutaneum, are unusual keratinous skin tumors with the appearance of horns, or sometimes of wood or coral. Formally, this is a clinical diagnosis for a "conical projection above the surface of the skin." They are usually small and localized but can, in very rare cases, be much larger. Although often benign, they can also be malignant or premalignant.
Parakeratosis is a mode of keratinization characterized by the retention of nuclei in the stratum corneum. In mucous membranes, parakeratosis is normal. In the skin, this process leads to the abnormal replacement of annular squames with nucleated cells. Parakeratosis is associated with the thinning or loss of the granular layer and is usually seen in diseases of increased cell turnover, whether inflammatory or neoplastic. Parakeratosis is seen in the plaques of psoriasis and in dandruff.
Psoriatic onychodystrophy or psoriatic nails is a nail disease. It is common in those with psoriasis, with reported incidences varying from 10% to 78%. Elderly patients and those with psoriatic arthritis are more likely to have psoriatic nails.
Guttate psoriasis is a type of psoriasis that presents as small lesions over the upper trunk and proximal extremities; it is found frequently in young adults.
Cello scrotum is a hoax medical condition originally published as a brief case report in the British Medical Journal in 1974. As its name suggests, it was purportedly an affliction of the scrotum affecting male players of the cello.
Acrokeratosis verruciformis is a rare autosomal dominant disorder appearing at birth or in early childhood, characterized by skin lesions that are small, verrucous, flat papules resembling warts along with palmoplantar punctate keratoses and pits. However sporadic forms, whose less than 10 cases have been reported, presents at a later age, usually after the first decade and generally lack palmoplantar keratoses. Whether acrokeratosis verruciformis and Darier disease are related or distinct entities has been controversial, like Darier's disease, it is associated with defects in the ATP2A2 gene. however the specific mutations found in the ATP2A2 gene in acrokeratosis verruciformis have never been found in Darier's disease.
Mark G. Lebwohl is an American dermatologist and author who is Professor and Chairman Emeritus of the Kimberly and Eric J. Waldman Department of Dermatology and the Dean for Clinical Therapeutics at the Icahn School of Medicine at Mount Sinai in New York City.
Harold Wordsworth Barber (1887–1955) was an English dermatologist.
Aditya Kumar Gupta is a Canadian academic and distinguished professor at the University of Toronto. He is also a Fellow of the American Academy of Dermatology, the Royal College of Physicians and Surgeons of Canada, and the European Confederation of Medical Mycology.
References
- ↑ Auspitz' symptom at Who Named It?
- ↑ Freiman, Anatoli; Kalia, Sunil; O'Brien, Elizabeth A. (July 2006). "Dermatologic Signs". Journal of Cutaneous Medicine and Surgery. 10 (4): 175–182. doi:10.2310/7750.2006.00042. PMID 17234116. S2CID 44484524.
- ↑ Woywodt, Alexander; Matteson, Eric (1 September 2007). "Head to Head: Should eponyms be abandoned? Yes". BMJ: British Medical Journal. 335 (7617): 424. doi:10.1136/bmj.39308.342639.AD. PMC 1962844 . PMID 17762033.
- ↑ Ferguson, Robert P.; Thomas, Deborah (2014). "Medical eponyms". Journal of Community Hospital Internal Medicine Perspectives. 4 (3): 10.3402/jchimp.v4.25046. doi:10.3402/jchimp.v4.25046. PMC 4120137 . PMID 25147644.
- ↑ "Acantholysis or the Auspitz sign? A revelation of the life of Carl Heinrich Auspitz". Indian Journal of Dermatology, Venereology and Leprology. 30 June 2017. Retrieved 26 December 2021.
- ↑ Kumar; et al. (2010). Robbin's Text book of Pathology. New Delhi: Elsevier. p. 841. ISBN 978-81-312-1036-9.
- ↑ Bernhard, J. D. (June 1990). "Auspitz sign is not sensitive or specific for psoriasis". Journal of the American Academy of Dermatology. 22 (6 Pt 1): 1079–1081. doi:10.1016/0190-9622(90)70155-b. ISSN 0190-9622. PMID 2370333 . Retrieved 26 December 2021.