Autophagy-related protein 13

ATG13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5C50
Identifiers
Aliases	ATG13 , KIAA0652, PARATARG8, autophagy related 13
External IDs	OMIM: 615088; MGI: 1196429; HomoloGene: 32229; GeneCards: ATG13; OMA:ATG13 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.2 Start 46,617,527 bp [1] End 46,674,818 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 91,504,963 bp [2] End 91,540,921 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis anterior pituitary epithelium of colon prefrontal cortex right frontal lobe skin of leg tibial nerve right hemisphere of cerebellum body of pancreas Top expressed in neural layer of retina superior frontal gyrus muscle of thigh dentate gyrus of hippocampal formation granule cell primary visual cortex lip blastocyst cerebellar cortex epithelium of lens esophagus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein kinase binding Cellular component cytoplasm cytosol Atg1/ULK1 kinase complex mitochondrion phagophore assembly site endoplasmic reticulum membrane Biological process autophagy macroautophagy autophagosome assembly positive regulation of protein targeting to mitochondrion mitophagy response to mitochondrial depolarisation regulation of macroautophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9776 51897 Ensembl ENSG00000175224 ENSMUSG00000027244 UniProt O75143 Q91YI1 RefSeq (mRNA) NM_001142673 NM_001205119 NM_001205120 NM_001205121 NM_001205122 NM_001346311 NM_001346312 NM_001346313 NM_001346314 NM_001346315 NM_001346316 NM_001346317 NM_001346318 NM_001346319 NM_001346320 NM_001346321 NM_001346322 NM_001346323 NM_001346324 NM_001346325 NM_001346326 NM_001346327 NM_001346328 NM_001346329 NM_001346330 NM_001346331 NM_001346332 NM_001346333 NM_001346334 NM_001346335 NM_001346336 NM_001346337 NM_001346338 NM_001346340 NM_001346342 NM_001346344 NM_001346346 NM_001346348 NM_001346349 NM_001346350 NM_001346351 NM_001346352 NM_001346353 NM_001346354 NM_001346355 NM_001346356 NM_001346357 NM_001346358 NM_001346359 NM_001346360 NM_014741 NM_145528 NM_001355416 NM_001355417 NM_001355418 NM_001355419 NM_001355420 NM_001355421 RefSeq (protein) NP_001136145 NP_001192048 NP_001192049 NP_001192050 NP_001192051 NP_001333240 NP_001333241 NP_001333242 NP_001333243 NP_001333244 NP_001333245 NP_001333246 NP_001333247 NP_001333248 NP_001333249 NP_001333250 NP_001333251 NP_001333252 NP_001333253 NP_001333254 NP_001333255 NP_001333256 NP_001333257 NP_001333258 NP_001333259 NP_001333260 NP_001333261 NP_001333262 NP_001333263 NP_001333264 NP_001333265 NP_001333266 NP_001333267 NP_001333269 NP_001333271 NP_001333273 NP_001333275 NP_001333277 NP_001333278 NP_001333279 NP_001333280 NP_001333281 NP_001333282 NP_001333283 NP_001333284 NP_001333285 NP_001333286 NP_001333287 NP_001333288 NP_001333289 NP_055556 NP_663503 NP_001342345 NP_001342346 NP_001342347 NP_001342348 NP_001342349 NP_001342350 Location (UCSC) Chr 11: 46.62 – 46.67 Mb Chr 2: 91.5 – 91.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Autophagy-related protein 13 also known as ATG13 is a protein that in humans is encoded by the KIAA0652 gene. ^[5]

ATG13 is an autophagy factor required for phagosome formation. ATG13 is a target of the TOR kinase signaling pathway that regulates autophagy through phosphorylation of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. ^{[6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000175224 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027244 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: KIAA0652".
6. Mercer CA, Kaliappan A, Dennis PB (July 2009). "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy". Autophagy. 5 (5): 649–62. doi: 10.4161/auto.5.5.8249 . PMID   19287211.
7. Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N (April 2009). "Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy". Mol. Biol. Cell. 20 (7): 1981–91. doi:10.1091/mbc.E08-12-1248. PMC   2663915 . PMID   19211835.
8. Chan EY, Longatti A, McKnight NC, Tooze SA (January 2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC   2612494 . PMID   18936157.

External links

• Human ATG13 genome location and ATG13 gene details page in the UCSC Genome Browser .

Further reading

• Hosokawa N, Sasaki T, Iemura S, et al. (2009). "Atg101, a novel mammalian autophagy protein interacting with Atg13". Autophagy. 5 (7): 973–9. doi: 10.4161/auto.5.7.9296 . PMID   19597335.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Chan EY (2009). "mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex". Science Signaling . 2 (84): pe51. doi:10.1126/scisignal.284pe51. PMID   19690328. S2CID   206673207.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Jung CH, Jun CB, Ro SH, et al. (2009). "ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery". Mol. Biol. Cell. 20 (7): 1992–2003. doi:10.1091/mbc.E08-12-1249. PMC   2663920 . PMID   19225151.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID   9734811.
• Chan EY, Longatti A, McKnight NC, Tooze SA (2009). "Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism". Mol. Cell. Biol. 29 (1): 157–71. doi:10.1128/MCB.01082-08. PMC   2612494 . PMID   18936157.
• Ganley IG, Lam du H, Wang J, et al. (2009). "ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy". J. Biol. Chem. 284 (18): 12297–305. doi: 10.1074/jbc.M900573200 . PMC   2673298 . PMID   19258318.
• Sinzelle L, Kapitonov VV, Grzela DP, et al. (2008). "Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes". Proc. Natl. Acad. Sci. U.S.A. 105 (12): 4715–20. Bibcode:2008PNAS..105.4715S. doi: 10.1073/pnas.0707746105 . PMC   2290759 . PMID   18339812.