BAAT

BAAT
Identifiers
Aliases	BAAT , BACAT, BAT, bile acid-CoA:amino acid N-acyltransferase, BACD1, HCHO
External IDs	OMIM: 602938 MGI: 106642 HomoloGene: 1286 GeneCards: BAAT
Gene location (Human)
Chr.	Chromosome 9 (human)
End	101,385,400 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	49,506,557 bp
RNA expression pattern
	Top expressed in
	liver; ; right lobe of liver; ; gallbladder; ; islet of Langerhans; ; superior frontal gyrus; ; gastrocnemius muscle; ; Brodmann area 9; ; prefrontal cortex; ; cingulate gyrus; ; cerebellum;
	Top expressed in
	left lobe of liver; ; gallbladder; ; jejunum; ; thoracic diaphragm; ; yolk sac; ; kidney; ; proximal tubule; ; colon; ; pancreas; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	thiolester hydrolase activity ; very long chain acyl-CoA hydrolase activity ; signaling receptor binding ; transferase activity ; medium-chain acyl-CoA hydrolase activity ; hydrolase activity ; N-acyltransferase activity ; palmitoyl-CoA hydrolase activity ; long-chain acyl-CoA hydrolase activity ; carboxylic ester hydrolase activity ; glycine N-choloyltransferase activity ; protein binding ; acyltransferase activity ; myristoyl-CoA hydrolase activity ; acyl-CoA hydrolase activity ;
Cellular component	cytoplasm ; peroxisome ; peroxisomal matrix ; cytosol ;
Biological process	bile acid conjugation ; liver development ; lipid metabolism ; animal organ regeneration ; acyl-CoA metabolic process ; taurine metabolic process ; bile acid metabolic process ; glycine metabolic process ; bile acid biosynthetic process ; fatty acid metabolic process ; protein targeting to peroxisome ;
	Sources:Amigo / QuickGO
Orthologs
	570
	12012
	ENSG00000136881 ; ENSG00000276559
	ENSMUSG00000039653
	Q14032
	Q91X34
	NM_001701 ; NM_001127610 ; NM_001374715
	NM_007519
	NP_001121082 ; NP_001692 ; NP_001361644
	NP_031545
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Bile acid-CoA:amino acid N-acyltransferase is an enzyme that in humans is encoded by the BAAT gene.^[5]

Related Research Articles

Lecithin–cholesterol acyltransferase is an enzyme, in many animals including humans, that converts free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) (alpha-LCAT) and LDLs (beta-LCAT) in the blood plasma. LCAT deficiency can cause impaired vision due to cholesterol corneal opacities, anemia, and kidney damage. It belongs to the family of phospholipid:diacylglycerol acyltransferases.

In enzymology, a bile acid-CoA:amino acid N-acyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a propanoyl-CoA C-acyltransferase is an enzyme that catalyzes the chemical reaction

Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme that in humans is encoded by the SOAT2 gene.

Glycine amidinotransferase, mitochondrial is an enzyme that in humans is encoded by the GATM gene.

Dimethylaniline monooxygenase [N-oxide-forming] 1 is an enzyme that in humans is encoded by the FMO1 gene.

UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an enzyme that in humans is encoded by the UGT2B4 gene.

Threonyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the TARS gene.

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme that in humans is encoded by the AGPAT1 gene.

Glycine-N-acyltransferase, also known as GLYAT, is an enzyme which in humans is encoded by the GLYAT gene.

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene.

Peroxisomal acyl-coenzyme A oxidase 3 is an enzyme that in humans is encoded by the ACOX3 gene.

<span class="mw-page-title-main">ECH1</span> Protein-coding gene in the species Homo sapiens

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an enzyme that in humans is encoded by the ECH1 gene.

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.

GBA2 is the gene that encodes the enzyme non-lysosomal glucosylceramidase in humans. It has glucosylceramidase activity.

Fatty acyl-CoA reductase 1 is an enzyme that in humans is encoded by the FAR1 gene.

Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene. GPAT-3 is also known as:

Delta-aminolevulinate synthase 1 also known as ALAS1 is a protein that in humans is encoded by the ALAS1 gene. ALAS1 is an aminolevulinic acid synthase.

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

Lecithin retinol acyltransferase is an enzyme that in humans is encoded by the LRAT gene.

References

1 2 3 ENSG00000276559 GRCh38: Ensembl release 89: ENSG00000136881, ENSG00000276559 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039653 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: BAAT bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)".

External links

Human BAAT genome location and BAAT gene details page in the UCSC Genome Browser .

Johnson MR, Barnes S, Kwakye JB, Diasio RB (1991). "Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver". J. Biol. Chem. 266 (16): 10227–33. doi: 10.1016/S0021-9258(18)99213-6 . PMID 2037576.
Falany CN, Johnson MR, Barnes S, Diasio RB (1994). "Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase". J. Biol. Chem. 269 (30): 19375–9. doi: 10.1016/S0021-9258(17)32178-6 . PMID 8034703.
Lench NJ, Telford EA, Andersen SE, et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3". Genomics. 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
Solaas K, Ulvestad A, Söreide O, Kase BF (2000). "Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts". J. Lipid Res. 41 (7): 1154–62. doi: 10.1016/S0022-2275(20)32022-8 . PMID 10884298.
Sfakianos MK, Wilson L, Sakalian M, et al. (2003). "Conserved residues in the putative catalytic triad of human bile acid Coenzyme A:amino acid N-acyltransferase". J. Biol. Chem. 277 (49): 47270–5. doi: 10.1074/jbc.M207463200 . PMID 12239217.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Carlton VE, Harris BZ, Puffenberger EG, et al. (2003). "Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT". Nat. Genet. 34 (1): 91–6. doi:10.1038/ng1147. PMID 12704386. S2CID 21900697.
Wang H, Tamba M, Kimata M, et al. (2003). "Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT". Biochem. Biophys. Res. Commun. 305 (3): 611–8. doi:10.1016/S0006-291X(03)00808-8. PMID 12763038.
O'Byrne J, Hunt MC, Rai DK, et al. (2003). "The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine". J. Biol. Chem. 278 (36): 34237–44. doi: 10.1074/jbc.M300987200 . PMID 12810727.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Pellicoro A, van den Heuvel FA, Geuken M, et al. (2007). "Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport". Hepatology. 45 (2): 340–8. doi: 10.1002/hep.21528 . PMID 17256745. S2CID 6163420.
Tougou K, Fukuda T, Ito T, et al. (2007). "Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals". Drug Metab. Pharmacokinet. 22 (2): 125–8. doi:10.2133/dmpk.22.125. PMID 17495420.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000276559 GRCh38: Ensembl release 89: ENSG00000136881, ENSG00000276559 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039653 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: BAAT bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)".

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BAAT

Contents

Related Research Articles

References

External links

Further reading