BAG2

BAG2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CQX, 3D0T
Identifiers
Aliases	BAG2 , BAG-2, dJ417I1.2, BCL2 associated athanogene 2, BAG cochaperone 2
External IDs	OMIM: 603882 MGI: 1891254 HomoloGene: 31233 GeneCards: BAG2
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p12.1 Start 57,172,326 bp [1] End 57,189,833 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 B Start 33,745,484 bp [2] End 33,757,795 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • chaperone binding • GO:0001948 protein binding • identical protein binding • adenyl-nucleotide exchange factor activity • heat shock protein binding • ubiquitin protein ligase binding • ion channel binding • tau protein binding Cellular component • cytosol • microtubules • axon • dendrite • chaperone complex • dendritic microtubule Biological process • regulation of cellular response to heat • protein metabolic process • protein folding • GO:0048552 regulation of catalytic activity • positive regulation of protein processing • negative regulation of protein ubiquitination • negative regulation of protein binding • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • protein stabilization • positive regulation of proteasomal protein catabolic process • GO:0060564, GO:1904190 negative regulation of ubiquitin protein ligase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9532	213539
Ensembl	ENSG00000112208	ENSMUSG00000042215
UniProt	O95816	Q91YN9
RefSeq (mRNA)	NM_004282	NM_145392
RefSeq (protein)	NP_004273	NP_663367
Location (UCSC)	Chr 6: 57.17 – 57.19 Mb	Chr 1: 33.75 – 33.76 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. ^{[5] [6]}

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. ^[6]

Interactions

BAG2 has been shown to interact with HSPA8. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000112208 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042215 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takayama S, Xie Z, Reed JC (Feb 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J Biol Chem. 274 (2): 781–6. doi: 10.1074/jbc.274.2.781 . PMID   9873016.
6. "Entrez Gene: BAG2 BCL2-associated athanogene 2".

External links

• Human BAG2 genome location and BAG2 gene details page in the UCSC Genome Browser .

Further reading

• Halse R, Rochford JJ, McCormack JG, et al. (1999). "Control of glycogen synthesis in cultured human muscle cells". J. Biol. Chem. 274 (2): 776–80. doi: 10.1074/jbc.274.2.776 . PMID   9873015.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Ueda K, Kosako H, Fukui Y, Hattori S (2004). "Proteomic identification of Bcl2-associated athanogene 2 as a novel MAPK-activated protein kinase 2 substrate". J. Biol. Chem. 279 (40): 41815–21. doi: 10.1074/jbc.M406049200 . PMID   15271996.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Dai Q, Qian SB, Li HH, et al. (2006). "Regulation of the cytoplasmic quality control protein degradation pathway by BAG2". J. Biol. Chem. 280 (46): 38673–81. doi: 10.1074/jbc.M507986200 . PMID   16169850.
• Arndt V, Daniel C, Nastainczyk W, et al. (2006). "BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP". Mol. Biol. Cell. 16 (12): 5891–900. doi:10.1091/mbc.E05-07-0660. PMC   1289430 . PMID   16207813.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.