BANP

BANP
Identifiers
Aliases	BANP , BEND1, SMAR1, SMARBP1, BTG3 associated nuclear protein
External IDs	OMIM: 611564; MGI: 1889023; HomoloGene: 9635; GeneCards: BANP; OMA:BANP - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q24.2 Start 87,949,244 bp [1] End 88,077,318 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 E1|8 70.82 cM Start 122,676,489 bp [2] End 122,755,997 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte blood pancreatic ductal cell middle temporal gyrus amniotic fluid Brodmann area 23 tendon of biceps brachii visceral pleura tibia Top expressed in tail of embryo genital tubercle zygote secondary oocyte Ileal epithelium granulocyte primary oocyte CA3 field morula yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding p53 binding protein binding identical protein binding Cellular component nucleus nucleoplasm nuclear body Biological process protein localization to nucleus multicellular organism development positive regulation of transcription, DNA-templated cell cycle regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of protein catabolic process regulation of signal transduction by p53 class mediator chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54971 53325 Ensembl ENSG00000172530 ENSMUSG00000025316 UniProt Q8N9N5 Q8VBU8 RefSeq (mRNA) NM_001173539 NM_001173540 NM_001173541 NM_001173542 NM_001173543 NM_017869 NM_079837 NM_001110100 NM_001285981 NM_001285983 NM_016812 RefSeq (protein) NP_001167010 NP_001167011 NP_001167012 NP_001167013 NP_001167014 NP_060339 NP_524576 NP_001103570 NP_001272910 NP_001272912 NP_058092 Location (UCSC) Chr 16: 87.95 – 88.08 Mb Chr 8: 122.68 – 122.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein BANP is a protein that can be found in humans, it is encoded by the BANP gene. ^{[5] [6] [7]} It is a member of the human gene family, "BEN-domain containing", which includes eight other genes: BEND2, BEND3, BEND4, BEND5, BEND6, BEND7, NACC1 (BEND8), and NACC2 (BEND9). BANP is a protein coding gene that is located in the Nucleoplasm. Its official name is BTG3 associated with nuclear protein. It plays a role in DNA binding, chromatin regulation, repressor, transcription regulation and the cell cycle process. ^[8] In recombination BANP protein represses T-cell receptors to control recombination during transcription. ^[9] As a tumor suppressor BANP negatively regulates p53 transcription in recombination. ^[10] It can be expressed in various tissues in the body including the testis, spleen, and the placenta. ^[11]

Function

This gene encodes a protein that binds to matrix attachment regions. The protein functions as a tumor suppressor and cell cycle regulator. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000172530 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025316 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Birot A, Duret L, Bartholin L, Santalucia B, Tigaud I, Magaud J, Rouault J (Aug 2000). "Identification and molecular analysis of BANP". Gene. 253 (2): 189–96. doi:10.1016/S0378-1119(00)00244-4. PMID   10940556.
6. Chattopadhyay S, Kaul R, Charest A, Housman D, Chen J (Aug 2000). "SMAR1, a novel, alternatively spliced gene product, binds the Scaffold/Matrix-associated region at the T cell receptor beta locus". Genomics. 68 (1): 93–6. doi:10.1006/geno.2000.6279. PMID   10950932.
7. "Entrez Gene: BANP BTG3 associated nuclear protein".
8. "National Center for Biotechnology Information". www.ncbi.nlm.nih.gov. Retrieved 2022-05-05.
9. www.nextprot.org https://www.nextprot.org/entry/NX_Q8N9N5/#! . Retrieved 2022-05-05.{{cite web}}: Missing or empty |title= (help)
10. "BANP BTG3 associated nuclear protein [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-05.
11. "BANP BTG3 associated nuclear protein [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-05-05.

External links

• Human BANP genome location and BANP gene details page in the UCSC Genome Browser .

Further reading

• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (Sep 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Kaul R, Mukherjee S, Ahmed F, Bhat MK, Chhipa R, Galande S, Chattopadhyay S (Feb 2003). "Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice". International Journal of Cancer. 103 (5): 606–15. doi: 10.1002/ijc.10881 . PMID   12494467. S2CID   22386279.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Kaul-Ghanekar R, Jalota A, Pavithra L, Tucker P, Chattopadhyay S (2004). "SMAR1 and Cux/CDP modulate chromatin and act as negative regulators of the TCRbeta enhancer (Ebeta)". Nucleic Acids Research. 32 (16): 4862–75. doi:10.1093/nar/gkh807. PMC   519105 . PMID   15371550.
• Kaul-Ghanekar R, Majumdar S, Jalota A, Gulati N, Dubey N, Saha B, Chattopadhyay S (Mar 2005). "Abnormal V(D)J recombination of T cell receptor beta locus in SMAR1 transgenic mice". The Journal of Biological Chemistry. 280 (10): 9450–9. doi: 10.1074/jbc.M412206200 . PMID   15623522.
• Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S (Oct 2005). "Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex". Molecular and Cellular Biology. 25 (19): 8415–29. doi:10.1128/MCB.25.19.8415-8429.2005. PMC   1265755 . PMID   16166625.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.