BAZ1A

Last updated

Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene. [1] [2]

Contents

Structure

The protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs: [1]

Function

BAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex. [3] [4]

The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent. [4] Furthermore, the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin. [5]

Interactions

BAZ1A has been shown to interact with SMARCA5 [3] [4] [6] [7] [8] and SATB1. [7]

References

  1. 1 2 Jones MH, Hamana N, Nezu J, Shimane M (Apr 2000). "A novel family of bromodomain genes". Genomics. 63 (1): 40–5. doi:10.1006/geno.1999.6071. PMID   10662543.
  2. ↑ "Entrez Gene: BAZ1A bromodomain adjacent to zinc finger domain, 1A".
  3. 1 2 Bochar DA, Savard J, Wang W, Lafleur DW, Moore P, Côté J, Shiekhattar R (February 2000). "A family of chromatin remodeling factors related to Williams syndrome transcription factor". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1038–43. Bibcode:2000PNAS...97.1038B. doi: 10.1073/pnas.97.3.1038 . PMC   15513 . PMID   10655480.
  4. 1 2 3 Poot RA, Dellaire G, Hülsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (July 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC   313940 . PMID   10880450.
  5. ↑ Collins N, Poot RA, Kukimoto I, García-Jiménez C, Dellaire G, Varga-Weisz PD (December 2002). "An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin". Nat. Genet. 32 (4): 627–32. doi:10.1038/ng1046. PMID   12434153. S2CID   22545162.
  6. ↑ Bozhenok, Ludmila; Wade Paul A; Varga-Weisz Patrick (May 2002). "WSTF–ISWI chromatin remodeling complex targets heterochromatic replication foci". EMBO J. 21 (9). England: 2231–41. doi:10.1093/emboj/21.9.2231. ISSN   0261-4189. PMC   125993 . PMID   11980720.
  7. 1 2 Yasui, Dag; Miyano Masaru; Cai Shutao; Varga-Weisz Patrick; Kohwi-Shigematsu Terumi (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature . 419 (6907). England: 641–5. Bibcode:2002Natur.419..641Y. doi:10.1038/nature01084. ISSN   0028-0836. PMID   12374985. S2CID   25822700.
  8. ↑ Hakimi, Mohamed-Ali; Bochar Daniel A; Schmiesing John A; Dong Yuanshu; Barak Orr G; Speicher David W; Yokomori Kyoko; Shiekhattar Ramin (Aug 2002). "A chromatin remodelling complex that loads cohesin onto human chromosomes". Nature . 418 (6901). England: 994–8. Bibcode:2002Natur.418..994H. doi:10.1038/nature01024. ISSN   0028-0836. PMID   12198550. S2CID   4344470.


This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.