BICD1

BICD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YTD
Identifiers
Aliases	BICD1 , BICD, BICD cargo adaptor 1, bic-D 1
External IDs	OMIM: 602204 MGI: 1101760 HomoloGene: 37518 GeneCards: BICD1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	32,383,633 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	149,464,827 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; ganglionic eminence; ; cerebellar vermis; ; right uterine tube; ; caput epididymis; ; trigeminal ganglion; ; spinal ganglia; ; Brodmann area 23; ; Brodmann area 46; ; canal of the cervix;
	Top expressed in
	sciatic nerve; ; mammillary body; ; ventromedial nucleus; ; lateral hypothalamus; ; substantia nigra; ; lateral geniculate nucleus; ; ventral tegmental area; ; habenula; ; cerebellar vermis; ; pontine nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	dynactin binding ; structural constituent of cytoskeleton ; proteinase activated receptor binding ; protein binding ; cytoskeletal anchor activity ; dynein complex binding ; protein kinase binding ; dynein intermediate chain binding ;
Cellular component	Golgi apparatus ; membrane ; host cell viral assembly compartment ; trans-Golgi network ; tubulin complex ; perinuclear region of cytoplasm ; cytoplasmic microtubule ; cytoskeleton ; cytoplasmic vesicle ; cytosol ; centrosome ;
Biological process	protein localization to organelle ; regulation of proteinase activated receptor activity ; positive regulation of receptor-mediated endocytosis ; RNA processing ; microtubule anchoring at microtubule organizing center ; negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ; negative regulation of phospholipase C activity ; anatomical structure morphogenesis ; intracellular mRNA localization ; minus-end-directed organelle transport along microtubule ; viral process ; stress granule assembly ; transport ; regulation of microtubule cytoskeleton organization ; positive regulation of protein localization to centrosome ;
	Sources:Amigo / QuickGO
Orthologs
	636
	12121
	ENSG00000151746
	ENSMUSG00000003452
	Q96G01
	Q8BR07
NM_001003398 ; NM_001714 ; NM_001354186 ; NM_001354187 ; NM_001354188 ;
	NM_001354189 ; NM_001363603
	NM_001112796 ; NM_009753
NP_001003398 ; NP_001705 ; NP_001341115 ; NP_001341116 ; NP_001341117 ;
	NP_001341118 ; NP_001350532
	NP_001106267 ; NP_033883
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 30, 2023

Bicaudal D cargo adaptor 1 is a protein that in humans is encoded by the BICD1 gene.^[5]^[6]

Function

This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.^[6]

Interactions

BICD1 has been shown to interact with RAB6A.^[7]^[8]

Related Research Articles

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<span class="mw-page-title-main">Anna Akhmanova</span> Russian cell biologist

Anna Sergeevna Akhmanova is a Russian-born professor of Cell Biology at Utrecht University in the Netherlands. She is best known for her research regarding microtubules and the proteins, called TIPs, that stabilize one specific end of the tubules. Among the awards she has won, she was one of the recipients of the 2018 Spinoza Prize, the highest honor for Dutch scientists.

Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene. Giantin is located at the cis-medial rims of the Golgi apparatus and is part of the Golgi matrix that is responsible for membrane trafficking in secretory pathway of proteins. This function is key for proper localisation of proteins at the plasma membrane and outside the cell which is important for cell function that is dependent on for example receptors and the extracellular matrix function. Recent animal model knockout studies of GOLGB1 in mice, rat, and zebrafish have shown that phenotypes are different between species ranging from mild to severe craniofacial defects in the rodent models to just minor size defects in zebrafish. However, in adult zebrafish a tumoral calcinosis-like phenotype was observed, and in humans such phenotype has been linked to defective glycosyltransferase function.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151746 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003452 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Baens M, Marynen P (Nov 1997). "A human homologue (BICD1) of the Drosophila bicaudal-D gene". Genomics. 45 (3): 601–6. doi:10.1006/geno.1997.4971. PMID 9367685.
1 2 "Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila)".
↑ Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. doi: 10.1016/S0960-9822(02)01221-6 . PMID 12401177. S2CID 14031165.
↑ Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.

External links

Human BICD1 genome location and BICD1 gene details page in the UCSC Genome Browser .

Barr FA, Short B (August 2003). "Golgins in the structure and dynamics of the Golgi apparatus". Current Opinion in Cell Biology. 15 (4): 405–13. doi:10.1016/S0955-0674(03)00054-1. PMID 12892780.
Claussen M, Suter B (November 2005). "BicD-dependent localization processes: from Drosophilia development to human cell biology". Annals of Anatomy - Anatomischer Anzeiger. 187 (5–6): 539–53. doi:10.1016/j.aanat.2005.07.004. PMID 16320833.
Baens M, Aerssens J, van Zand K, Van den Berghe H, Marynen P (September 1995). "Isolation and regional assignment of human chromosome 12p cDNAs". Genomics. 29 (1): 44–52. doi:10.1006/geno.1995.1213. PMID 8530100.
Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (October 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. doi: 10.1016/S0960-9822(02)01221-6 . PMID 12401177. S2CID 14031165.
Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.
Tomsig JL, Snyder SL, Creutz CE (Mar 2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". The Journal of Biological Chemistry. 278 (12): 10048–54. doi: 10.1074/jbc.M212632200 . PMID 12522145.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Fuchs E, Short B, Barr FA (2006). "Assay and Properties of Rab6 Interaction with Dynein–Dynactin Complexes". GTPases Regulating Membrane Targeting and Fusion. Methods in Enzymology. Vol. 403. pp. 607–18. doi:10.1016/S0076-6879(05)03053-3. ISBN 9780121828080. PMID 16473624.
Moorhead AR, Rzomp KA, Scidmore MA (Feb 2007). "The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner". Infection and Immunity. 75 (2): 781–91. doi:10.1128/IAI.01447-06. PMC 1828475 . PMID 17101644.
Fumoto K, Hoogenraad CC, Kikuchi A (December 2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome". The EMBO Journal. 25 (24): 5670–82. doi:10.1038/sj.emboj.7601459. PMC 1698904 . PMID 17139249.
Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA (Oct 2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells". Experimental Cell Research. 313 (16): 3408–20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000151746 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003452 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9367685-5] Baens M, Marynen P (Nov 1997). "A human homologue (BICD1) of the Drosophila bicaudal-D gene". Genomics. 45 (3): 601–6. doi:10.1006/geno.1997.4971. PMID 9367685.

[entrez-6] 1 2 "Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila)".

[pmid12401177-7] Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. doi: 10.1016/S0960-9822(02)01221-6 . PMID 12401177. S2CID 14031165.

[pmid12447383-8] Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.

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