BNIP2

BNIP2
Identifiers
Aliases	BNIP2 , BNIP-2, NIP2, BCL2/adenovirus E1B 19kDa interacting protein 2, BCL2 interacting protein 2
External IDs	OMIM: 603292 MGI: 109327 HomoloGene: 3194 GeneCards: BNIP2
Gene location (Human)
Chr.	Chromosome 15 (human)
End	59,689,534 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	69,915,599 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; monocyte; ; bone marrow cells; ; rectum; ; body of pancreas; ; minor salivary gland; ; right uterine tube; ; right lung; ; gallbladder; ; left lobe of thyroid gland;
	Top expressed in
	ascending aorta; ; aortic valve; ; iris; ; ciliary body; ; fossa; ; body of femur; ; condyle; ; renal corpuscle; ; retinal pigment epithelium; ; conjunctival fornix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity ; calcium ion binding ; identical protein binding ; protein binding ; exopolyphosphatase activity ;
Cellular component	perinuclear region of cytoplasm ; cytoplasm ; intracellular membrane-bounded organelle ; nuclear envelope ; cytosol ; membrane ; integral component of membrane ;
Biological process	positive regulation of muscle cell differentiation ; negative regulation of apoptotic process ; apoptotic process ; positive regulation of GTPase activity ; polyphosphate catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	663
	12175
	ENSG00000140299
	ENSMUSG00000011958
	Q12982
	O54940
	NM_004330 ; NM_001320674 ; NM_001320675
	NM_001008238 ; NM_016787 ; NM_001374750
NP_001307603 ; NP_001307604 ; NP_004321 ; NP_001354986 ; NP_001354987 ;
	NP_001354988 ; NP_001354989 ; NP_001354990
	NP_001008239 ; NP_058067 ; NP_001361679
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 26, 2022

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.^[5]^[6]

Function

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. Though the specific function is unknown, it interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL-2, also an apoptotic protector.^[6]

Interactions

BNIP2 has been shown to interact with:

Related Research Articles

Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. BAX is a member of the Bcl-2 gene family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.

The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology (BH) domains, and can form hetero- or homodimers. Bcl-2 proteins act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.

<span class="mw-page-title-main">CDC42</span> Protein-coding gene in the species Homo sapiens

Cell division control protein 42 homolog, also known as Cdc42, is a protein involved in regulation of the cell cycle. It was originally identified in S. cerevisiae (yeast) as a mediator of cell division, and is now known to influence a variety of signaling events and cellular processes in a variety of organisms from yeast to mammals.

Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene.

Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene.

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 is a protein that in humans is encoded by the BNIP3 gene.

14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.

Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene.

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.

Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like is a protein that in humans is encoded by the BNIP3L gene.

Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.

BAG family molecular chaperone regulator 4 is a protein that in humans is encoded by the BAG4 gene.

RalBP1-associated Eps domain-containing protein 1 is a protein that in humans is encoded by the REPS1 gene.

Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene.

Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene.

Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein is a protein that in humans is encoded by the BNIPL gene.

Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene.

Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.

The Rho GTPase activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000140299 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000011958 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G (November 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341–51. doi:10.1016/0092-8674(94)90202-X. PMID 7954800. S2CID 38609845.
1 2 "Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2".
1 2 Low BC, Seow KT, Guy GR (December 2000). "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48): 37742–51. doi: 10.1074/jbc.M004897200 . PMID 10954711.
1 2 Low BC, Lim YP, Lim J, Wong ES, Guy GR (November 1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46): 33123–30. doi: 10.1074/jbc.274.46.33123 . PMID 10551883.
↑ Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (August 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochem. Biophys. Res. Commun. 308 (2): 379–85. doi:10.1016/s0006-291x(03)01387-1. PMID 12901880.
↑ Low BC, Seow KT, Guy GR (May 2000). "Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2". J. Biol. Chem. 275 (19): 14415–22. doi: 10.1074/jbc.275.19.14415 . PMID 10799524.

External links

Human BNIP2 genome location and BNIP2 gene details page in the UCSC Genome Browser .

Belcredito S, Vegeto E, Brusadelli A, et al. (2002). "Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2". Brain Res. Brain Res. Rev. 37 (1–3): 335–42. doi:10.1016/S0165-0173(01)00138-2. PMID 11744098. S2CID 22189937.
Ohi N, Tokunaga A, Tsunoda H, et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region". Cell Death Differ. 6 (4): 314–25. doi: 10.1038/sj.cdd.4400493 . PMID 10381623.
Zhou YT, Soh UJ, Shang X, et al. (2002). "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence". J. Biol. Chem. 277 (9): 7483–92. doi: 10.1074/jbc.M109459200 . PMID 11741952.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46): 45903–14. doi: 10.1074/jbc.M304514200 . PMID 12944407.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Zhou YT, Guy GR, Low BC (2005). "BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain". Exp. Cell Res. 303 (2): 263–74. doi:10.1016/j.yexcr.2004.08.044. PMID 15652341.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000140299 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000011958 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7954800-5] 1 2 Boyd JM, Malstrom S, Subramanian T, Venkatesh LK, Schaeper U, Elangovan B, D'Sa-Eipper C, Chinnadurai G (November 1994). "Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins". Cell. 79 (2): 341–51. doi:10.1016/0092-8674(94)90202-X. PMID 7954800. S2CID 38609845.

[entrez-6] 1 2 "Entrez Gene: BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2".

[pmid10954711-7] 1 2 Low BC, Seow KT, Guy GR (December 2000). "The BNIP-2 and Cdc42GAP homology domain of BNIP-2 mediates its homophilic association and heterophilic interaction with Cdc42GAP". J. Biol. Chem. 275 (48): 37742–51. doi: 10.1074/jbc.M004897200 . PMID 10954711.

[pmid10551883-8] 1 2 Low BC, Lim YP, Lim J, Wong ES, Guy GR (November 1999). "Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42". J. Biol. Chem. 274 (46): 33123–30. doi: 10.1074/jbc.274.46.33123 . PMID 10551883.

[pmid12901880-9] Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (August 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochem. Biophys. Res. Commun. 308 (2): 379–85. doi:10.1016/s0006-291x(03)01387-1. PMID 12901880.

[pmid10799524-10] Low BC, Seow KT, Guy GR (May 2000). "Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2". J. Biol. Chem. 275 (19): 14415–22. doi: 10.1074/jbc.275.19.14415 . PMID 10799524.

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