BRAT1

BRAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IFI
Identifiers
Aliases	BRAT1 , BAAT1, C7orf27, RMFSL, BRCA1 associated ATM activator 1, NEDCAS
External IDs	OMIM: 614506 MGI: 1891679 HomoloGene: 16776 GeneCards: BRAT1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	2,555,694 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	140,705,134 bp
RNA expression pattern
	Top expressed in
	stomach; ; body of stomach; ; prostate;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:0001948 protein binding ;
Cellular component	cytoplasm ; membrane ; nucleus ; nucleoplasm ;
Biological process	mitochondrion localization ; response to ionizing radiation ; cell growth ; positive regulation of protein phosphorylation ; cell population proliferation ; cell migration ; glucose metabolic process ; cellular response to DNA damage stimulus ; apoptotic process ; positive regulation of cell growth ;
	Sources:Amigo / QuickGO
Orthologs
	221927
	231841
	ENSG00000106009
	ENSMUSG00000000148
	Q6PJG6
	Q8C3R1
	NM_152743 ; NM_001350626 ; NM_001350627
	NM_001276287 ; NM_172724 ; NM_181066
	NP_689956 ; NP_001337555 ; NP_001337556
	NP_001263216 ; NP_851411
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 13, 2022

BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene.^[5]

Function

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.^[5]

Related Research Articles

Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene. It is a large kinase of about 301.66 kDa. ATR belongs to the phosphatidylinositol 3-kinase-related kinase protein family. ATR is activated in response to single strand breaks, and works with ATM to ensure genome integrity.

CHEK2 is a tumor suppressor gene that encodes the protein CHK2, a serine-threonine kinase. CHK2 is involved in DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers.

Claspin is a protein that in humans is encoded by the CLSPN gene.

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.

AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene.

E3 ubiquitin-protein ligase FANCL is an enzyme that in humans is encoded by the FANCL gene.

BRCA1-A complex subunit RAP80 is a protein that in humans is encoded by the UIMC1 gene.

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.

BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.

BRCC3 Protein-coding gene in the species Homo sapiens

Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.

Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene.

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein that in humans is encoded by the SMARCD2 gene.

Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.

Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.

Secreted and transmembrane protein 1 is a protein that in humans is encoded by the SECTM1 gene.

Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene.

Aldehyde dehydrogenase 8 family, member A1 also known as ALDH8A1 is an enzyme that in humans is encoded by the ALDH8A1 gene.

Jumonji domain containing 1C is a protein that in humans is encoded by the JMJD1C gene.

TELO2 interacting protein 2 is a protein that in humans is encoded by the TTI2 gene.

Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106009 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000148 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: BRCA1-associated ATM activator 1".

External links

Human BRAT1 genome location and BRAT1 gene details page in the UCSC Genome Browser .
PDBe-KB provides an overview of all the structure information available in the PDB for Human BRCA1-associated ATM activator

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000106009 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000148 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: BRCA1-associated ATM activator 1".

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BRAT1

Contents

Function

Related Research Articles

References

External links