BRAT1

BRAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IFI
Identifiers
Aliases	BRAT1 , BAAT1, C7orf27, RMFSL, BRCA1 associated ATM activator 1, NEDCAS
External IDs	OMIM: 614506; MGI: 1891679; HomoloGene: 16776; GeneCards: BRAT1; OMA:BRAT1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p22.3 Start 2,537,810 bp [1] End 2,555,694 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 G2 Start 140,690,766 bp [2] End 140,705,134 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left adrenal cortex granulocyte right adrenal gland right adrenal cortex right testis left testis gonad right hemisphere of cerebellum right uterine tube right ovary Top expressed in interventricular septum granulocyte Rostral migratory stream spermatocyte lumbar spinal ganglion right kidney ascending aorta endocardial cushion external carotid artery proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytoplasm membrane nucleus nucleoplasm Biological process mitochondrion localization response to ionizing radiation cell growth positive regulation of protein phosphorylation cell population proliferation cell migration glucose metabolic process cellular response to DNA damage stimulus apoptotic process positive regulation of cell growth Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 221927 231841 Ensembl ENSG00000106009 ENSMUSG00000000148 UniProt Q6PJG6 Q8C3R1 RefSeq (mRNA) NM_152743 NM_001350626 NM_001350627 NM_001276287 NM_172724 NM_181066 RefSeq (protein) NP_689956 NP_001337555 NP_001337556 NP_001263216 NP_851411 Location (UCSC) Chr 7: 2.54 – 2.56 Mb Chr 5: 140.69 – 140.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene. ^[5]

Function

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRCA1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000106009 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000148 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: BRCA1-associated ATM activator 1".

External links

• Human BRAT1 genome location and BRAT1 gene details page in the UCSC Genome Browser .
• PDBe-KB provides an overview of all the structure information available in the PDB for Human BRCA1-associated ATM activator