BRMS1

BRMS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XUS, 4AUV
Identifiers
Aliases	BRMS1 , breast cancer metastasis suppressor 1, transcriptional repressor and anoikis regulator, BRMS1 transcriptional repressor and anoikis regulator
External IDs	OMIM: 606259 MGI: 2388804 HomoloGene: 32260 GeneCards: BRMS1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,345,125 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,099,945 bp
RNA expression pattern
	Top expressed in
	monocyte; ; skin of abdomen; ; body of stomach; ; body of pancreas; ; sural nerve; ; minor salivary gland; ; blood; ; right lobe of thyroid gland; ; spleen; ; left lobe of thyroid gland;
	Top expressed in
	spermatid; ; yolk sac; ; morula; ; lip; ; spermatocyte; ; superior frontal gyrus; ; proximal tubule; ; thymus; ; neural tube; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	histone deacetylase binding ; protein binding ; NF-kappaB binding ; histone deacetylase activity ;
Cellular component	cytoplasm ; Sin3-type complex ; nucleus ; nucleoplasm ;
Biological process	positive regulation of protein deacetylation ; positive regulation of anoikis ; negative regulation of transcription, DNA-templated ; negative regulation of NF-kappaB transcription factor activity ; negative regulation of transcription by RNA polymerase II ; histone deacetylation ; regulation of transcription, DNA-templated ; transcription, DNA-templated ; apoptotic process ; regulation of apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	25855
	107392
	ENSG00000174744
	ENSMUSG00000080268
	Q9HCU9
	Q99N20
	NM_015399 ; NM_001024957 ; NM_001024958
	NM_134155 ; NM_001374047 ; NM_001374048
	NP_001020128 ; NP_056214
	NP_598916 ; NP_001360976 ; NP_001360977
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 30, 2023

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.^[5]^[6]

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.^[7] The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.^[6]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174744 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000080268 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Research . 60 (11): 2764–9. PMID 10850410.
1 2 "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
↑ Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

External links

Human BRMS1 genome location and BRMS1 gene details page in the UCSC Genome Browser .

Meehan WJ, Welch DR (2003). "Breast cancer metastasis suppressor 1: update". Clin. Exp. Metastasis. 20 (1): 45–50. doi:10.1023/A:1022542519586. PMID 12650606. S2CID 26142383.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Samant RS, Debies MT, Shevde LA, et al. (2002). "Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1)". Int. J. Cancer . 97 (1): 15–20. doi: 10.1002/ijc.1569 . PMID 11774238. S2CID 19747938.
Shevde LA, Samant RS, Goldberg SF, et al. (2002). "Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1". Exp. Cell Res. 273 (2): 229–39. doi:10.1006/excr.2001.5452. PMID 11822878.
Janneau JL, Maldonado-Estrada J, Tachdjian G, et al. (2002). "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells". J. Clin. Endocrinol. Metab. 87 (11): 5336–9. doi: 10.1210/jc.2002-021093 . PMID 12414911.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Meehan WJ, Samant RS, Hopper JE, et al. (2004). "Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription". J. Biol. Chem. 279 (2): 1562–9. doi: 10.1074/jbc.M307969200 . PMID 14581478.
Cicek M, Samant RS, Kinter M, et al. (2004). "Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells". Clin. Exp. Metastasis. 21 (2): 149–57. doi:10.1023/B:CLIN.0000024729.19084.f0. PMID 15168732. S2CID 19383717.
Nikolaev AY, Papanikolaou NA, Li M, et al. (2004). "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex". Biochem. Biophys. Res. Commun. 323 (4): 1216–22. doi:10.1016/j.bbrc.2004.08.227. PMID 15451426.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Stark AM, Tongers K, Maass N, et al. (2005). "Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases". J. Cancer Res. Clin. Oncol. 131 (3): 191–8. doi:10.1007/s00432-004-0629-9. PMID 15592684. S2CID 12411341.
DeWald DB, Torabinejad J, Samant RS, et al. (2005). "Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells". Cancer Res. 65 (3): 713–7. doi: 10.1158/0008-5472.713.65.3 . PMID 15705865. S2CID 24886361.
Cicek M, Fukuyama R, Welch DR, et al. (2005). "Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity". Cancer Res. 65 (9): 3586–95. doi: 10.1158/0008-5472.CAN-04-3139 . PMID 15867352.
Hurst DR, Mehta A, Moore BP, et al. (2006). "Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone". Biochem. Biophys. Res. Commun. 348 (4): 1429–35. doi:10.1016/j.bbrc.2006.08.005. PMC 1557677 . PMID 16919237.
Samant RS, Clark DW, Fillmore RA, et al. (2007). "Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation". Mol. Cancer. 6: 6. doi:10.1186/1476-4598-6-6. PMC 1796551 . PMID 17227585.
Rivera J, Megias D, Bravo J (2007). "Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1". J. Proteome Res. 6 (10): 4006–18. doi:10.1021/pr0703167. PMID 17854218.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000174744 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000080268 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10850410-5] Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Research . 60 (11): 2764–9. PMID 10850410.

[entrez-6] 1 2 "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".

[7] Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

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BRMS1

Contents

Related Research Articles

References

External links

Further reading