BRMS1

Last updated
BRMS1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BRMS1 , breast cancer metastasis suppressor 1, transcriptional repressor and anoikis regulator, BRMS1 transcriptional repressor and anoikis regulator
External IDs OMIM: 606259; MGI: 2388804; HomoloGene: 32260; GeneCards: BRMS1; OMA:BRMS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015399
NM_001024957
NM_001024958

NM_134155
NM_001374047
NM_001374048

RefSeq (protein)

NP_001020128
NP_056214

NP_598916
NP_001360976
NP_001360977

Location (UCSC) Chr 11: 66.34 – 66.35 Mb Chr 19: 5.09 – 5.1 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene. [5] [6]

Contents

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. [7] The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000174744 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000080268 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Research . 60 (11): 2764–9. PMID   10850410.
  6. 1 2 "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
  7. Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

Further reading