BTBD2

BTBD2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3NO8
Identifiers
Aliases	BTBD2 , BTB domain containing 2
External IDs	OMIM: 608531; MGI: 1933831; HomoloGene: 32365; GeneCards: BTBD2; OMA:BTBD2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.3 Start 1,985,438 bp [1] End 2,034,881 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 C1 Start 80,478,451 bp [2] End 80,492,905 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe right hemisphere of cerebellum anterior cingulate cortex stromal cell of endometrium right uterine tube amygdala right ovary ventricular zone apex of heart left ovary Top expressed in interventricular septum dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex internal carotid artery external carotid artery muscle of thigh neural layer of retina zygote otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding Cellular component cytoplasm SCF ubiquitin ligase complex cytosol P-body Biological process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteolysis neurogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55643 208198 Ensembl ENSG00000133243 ENSMUSG00000003344 UniProt Q9BX70 n/a RefSeq (mRNA) NM_017797 NM_145361 NM_001379084 RefSeq (protein) NP_060267 n/a Location (UCSC) Chr 19: 1.99 – 2.03 Mb Chr 10: 80.48 – 80.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

BTB/POZ domain-containing protein 2 is a protein that in humans is encoded by the BTBD2 gene. ^{[5] [6]}

Function

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. ^[6]

Interactions

BTBD2 has been shown to interact with TOP1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000133243 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003344 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Carim-Todd L, Sumoy L, Andreu N, Estivill X, Escarceller M (Jan 2001). "Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24". Gene. 262 (1–2): 275–81. doi:10.1016/S0378-1119(00)00513-8. PMID   11179693.
6. "Entrez Gene: BTBD2 BTB (POZ) domain containing 2".
7. Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y, D'Arpa P (2002). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics. 3 1. doi: 10.1186/1471-2164-3-1 . PMC   64781 . PMID   11818025.

External links

• Human BTBD2 genome location and BTBD2 gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : Q9BX70 (BTB/POZ domain-containing protein 2) at the PDBe-KB .

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y, D'Arpa P (2003). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics. 3 1. doi: 10.1186/1471-2164-3-1 . PMC   64781 . PMID   11818025.
• Yamada A, Kawano K, Koga M, Takamori S, Nakagawa M, Itoh K (Jun 2003). "Gene and peptide analyses of newly defined lung cancer antigens recognized by HLA-A2402-restricted tumor-specific cytotoxic T lymphocytes". Cancer Research. 63 (11): 2829–35. PMID   12782588.
• Xu L, Yang L, Moitra PK, Hashimoto K, Rallabhandi P, Kaul S, Meroni G, Jensen JP, Weissman AM, D'Arpa P (Aug 2003). "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta". Experimental Cell Research. 288 (1): 84–93. doi:10.1016/S0014-4827(03)00187-3. PMID   12878161.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.