BTBD2

BTBD2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3NO8
Identifiers
Aliases	BTBD2 , BTB domain containing 2
External IDs	OMIM: 608531 MGI: 1933831 HomoloGene: 32365 GeneCards: BTBD2
Gene location (Human)
Chr.	Chromosome 19 (human)
End	2,034,881 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,492,905 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; right uterine tube; ; amygdala; ; ganglionic eminence; ; prefrontal cortex; ; right lobe of thyroid gland; ; Brodmann area 9; ; nucleus accumbens; ; canal of the cervix; ; left uterine tube;
	Top expressed in
	interventricular septum; ; superior frontal gyrus; ; internal carotid artery; ; external carotid artery; ; saccule; ; neural tube; ; cerebellar cortex; ; lip; ; secondary oocyte; ; otic placode;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ; ubiquitin protein ligase binding ;
Cellular component	cytoplasm ; SCF ubiquitin ligase complex ; cytosol ; P-body ;
Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process ; regulation of proteolysis ; neurogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	55643
	208198
	ENSG00000133243
	ENSMUSG00000003344
	Q9BX70
	n/a
	NM_017797
	NM_145361 ; NM_001379084
	NP_060267
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 30, 2022

BTB/POZ domain-containing protein 2 is a protein that in humans is encoded by the BTBD2 gene.^[5]^[6]

Function

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.^[6]

Interactions

BTBD2 has been shown to interact with TOP1.^[7]

Related Research Articles

DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene. It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA.

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.

Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene.

Transcriptional regulator Kaiso is a protein that in humans is encoded by the ZBTB33 gene. This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2, which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.

Nucleus accumbens-associated protein 1 is a protein that in humans is encoded by the NACC1 gene.

PHD finger protein 10 is a protein that in humans is encoded by the PHF10 gene.

Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ZBTB7A gene.

BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the BTBD1 gene.

POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene.

Zinc finger protein 295 is a protein that in humans is encoded by the ZNF295 gene.

Zinc finger protein 219 is a protein that in humans is encoded by the ZNF219 gene.

Ankyrin repeat and FYVE domain-containing protein 1 is a protein that in humans is encoded by the ANKFY1 gene.

Zinc finger and BTB domain-containing protein 20 is a protein that in humans is encoded by the ZBTB20 gene.

Kelch repeat and BTB domain-containing protein 7 is a protein that in humans is encoded by the KBTBD7 gene.

Rho-related BTB domain-containing protein 1 is a protein that in humans is encoded by the RHOBTB1 gene.

BTB domain containing 9 is a protein that in humans is encoded by the BTBD9 gene.

Ankyrin repeat and BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the ABTB1 gene.

Kelch repeat and BTB domain-containing protein 10 is a protein that in humans is encoded by the KBTBD10 gene.

Potassium channel tetramerisation domain containing 15 also known as BTB/POZ domain-containing protein KCTD15 is protein that in humans is encoded by the KCTD15 gene.

Centrosomal protein of 97 kDa (Cep97), also known as leucine-rich repeat and IQ domain-containing protein 2 (LRRIQ2), is a protein that in humans is encoded by the CEP97 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133243 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003344 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Carim-Todd L, Sumoy L, Andreu N, Estivill X, Escarceller M (Jan 2001). "Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24". Gene. 262 (1–2): 275–81. doi:10.1016/S0378-1119(00)00513-8. PMID 11179693.
1 2 "Entrez Gene: BTBD2 BTB (POZ) domain containing 2".
↑ Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y, D'Arpa P (2002). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics. 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781 . PMID 11818025.

External links

Human BTBD2 genome location and BTBD2 gene details page in the UCSC Genome Browser .
Overview of all the structural information available in the PDB for UniProt : Q9BX70 (BTB/POZ domain-containing protein 2) at the PDBe-KB .

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y, D'Arpa P (2003). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics. 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781 . PMID 11818025.
Yamada A, Kawano K, Koga M, Takamori S, Nakagawa M, Itoh K (Jun 2003). "Gene and peptide analyses of newly defined lung cancer antigens recognized by HLA-A2402-restricted tumor-specific cytotoxic T lymphocytes". Cancer Research. 63 (11): 2829–35. PMID 12782588.
Xu L, Yang L, Moitra PK, Hashimoto K, Rallabhandi P, Kaul S, Meroni G, Jensen JP, Weissman AM, D'Arpa P (Aug 2003). "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta". Experimental Cell Research. 288 (1): 84–93. doi:10.1016/S0014-4827(03)00187-3. PMID 12878161.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148 . PMID 15231748.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000133243 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003344 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11179693-5] Carim-Todd L, Sumoy L, Andreu N, Estivill X, Escarceller M (Jan 2001). "Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24". Gene. 262 (1–2): 275–81. doi:10.1016/S0378-1119(00)00513-8. PMID 11179693.

[entrez-6] 1 2 "Entrez Gene: BTBD2 BTB (POZ) domain containing 2".

[pmid11818025-7] Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y, D'Arpa P (2002). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics. 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781 . PMID 11818025.

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