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Endocrinology is a branch of biology and medicine dealing with the endocrine system, its diseases, and its specific secretions known as hormones. It is also concerned with the integration of developmental events proliferation, growth, and differentiation, and the psychological or behavioral activities of metabolism, growth and development, tissue function, sleep, digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and sensory perception caused by hormones. Specializations include behavioral endocrinology and comparative endocrinology.
Insulin is a peptide hormone produced by beta cells of the pancreatic islets encoded in humans by the insulin (INS) gene. It is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells. In these tissues the absorbed glucose is converted into either glycogen via glycogenesis or fats (triglycerides) via lipogenesis, or, in the case of the liver, into both. Glucose production and secretion by the liver is strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into large molecules inside the cells. Low insulin levels in the blood have the opposite effect by promoting widespread catabolism, especially of reserve body fat.
Sir Frederick Grant Banting was a Canadian medical scientist, physician, painter, and Nobel laureate noted as the co-discoverer of insulin and its therapeutic potential.
Bernardo Alberto Houssay was an Argentine physiologist. Houssay was a co-recipient of the 1947 Nobel Prize for Physiology or Medicine for discovering the role played by pituitary hormones in regulating the amount of glucose in animals, sharing the prize with Carl Ferdinand Cori and Gerty Cori. He is the first Latin American Nobel laureate in the sciences.
Zvi Laron is an Israeli paediatric endocrinologist. Born in Cernăuţi, Romania, Laron is a professor emeritus at Tel Aviv University. In 1966, he described the type of dwarfism later called Laron syndrome. His research opened the way to the treatment of many cases of growth hormone disorders. He was the first to introduce the multidisciplinary treatment for juvenile diabetes.
George P. Chrousos is professor of Pediatrics and Endocrinology Emeritus and former chairman of the Department of Pediatrics at the Athens University Medical School, Greece. Earlier he was senior investigator, director of the Pediatric Endocrinology Section and Training Program, and chief of the Pediatric and Reproductive Endocrinology Branch of the National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH). He is also clinical professor of Pediatrics, Physiology and Biophysics at Georgetown University Medical School and distinguished visiting scientist, NICHD, NIH. Dr. Chrousos was the first general director of the Foundation of Biomedical Research of the Academy of Athens (2001–2002). He holds the UNESCO Chair on Adolescent Health Care, while he held the 2011 John Kluge Chair in Technology and Society, Library of Congress, Washington, D.C.
Derek LeRoith is a South African endocrinologist and Professor of Medicine and the current Chief of the Hilda and J. Lester Gabrilove, M.D. Division of Endocrinology, Diabetes and Bone Disease and Director of the Metabolism Institute of the Mount Sinai Medical Center in New York City. He is an international expert in insulin-like growth factor-1 (IGF-1).
Mitchell Lazar is an endocrinologist and physician-scientist known for his discovery of the hormone resistin and his contributions to the transcriptional regulation of metabolism.
Ray Fletcher Farquharson was a Canadian medical doctor, university professor, and medical researcher. Born in Claude, Ontario, he attended and taught at the University of Toronto for most of his life, and was trained and employed at Toronto General Hospital. With co-researcher Arthur Squires, Farquharson was responsible for the discovery of the Farquharson phenomenon, an important principle of endocrinology, which is that administering external hormones suppresses the natural production of that hormone.
Leonid Poretsky is a Russian-born American endocrinologist. His research interests include mechanisms of insulin action in the ovary, endocrinological aspects of AIDS, and clinical outcomes in diabetes. He has authored over 150 publications and has served on the National Institutes of Health's review committees and on the editorial boards of the Journal of Clinical Endocrinology and Metabolism and other endocrine journals.
Carl Ronald Kahn is an American physician and scientist, best known for his work with insulin receptors and insulin resistance in diabetes and obesity. He is the Chief Academic Officer at Joslin Diabetes Center, the Mary K. Iacocca Professor of Medicine at Harvard Medical School and a member of the National Academy of Sciences since 1999.
José F. Caro is an American physician, scientist, and educator most notable for his research in obesity and diabetes. The Institute for Scientific Information listed him the third most cited investigator in the world in the field of obesity research during the 1991-2000 period for his work on Leptin. Caro is an artist and a signature member of the Pastel Society of America.
Mladen Vranic, MD, DSc, O.C., O.Ont, FRSC, FRCP(C), FCAHS, Canadian Medical Hall of Fame[CMHF] April 3, 1930 – June 18, 2019, was a Croatian-born diabetes researcher, best known for his work in tracer methodology, exercise and stress in diabetes, the metabolic effects of hormonal interactions, glucagon physiology, extrapancreatic glucagon, the role of the direct and indirect metabolic effects of insulin and the prevention of hypoglycemia. Vranic was recognized by a number of national and international awards for his research contributions, mentoring and administration including the Orders of Canada (Officer) and Ontario.
Matthias H. Tschöp is a German physician and scientist. He is the chief executive officer and scientific director of Helmholtz Zentrum München, German Research Center for Environmental Health. He is also Alexander von Humboldt Professor and chair of metabolic diseases at Technical University of Munich and serves as an adjunct professor at Yale University.
Daniel Joshua Drucker is a Canadian endocrinologist. A Fellow of the Royal Society, he is a professor of medicine at the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto. He is known for his research into intestinal hormones and their use in the treatment of diabetes and other metabolic diseases.
Ora Mendelsohn Rosen was an American medical researcher who investigated the influence of hormones, particularly insulin, on the control of cell growth. She was a professor at the Albert Einstein College of Medicine and Memorial Sloan Kettering Cancer Center and a member of the National Academy of Sciences.
Gökhan S. Hotamisligil is a Turkish-American physician scientist; James Stevens Simmons Chair of Genetics and Metabolism at Harvard T.H. Chan School of Public Health (HSPH); Director of the Sabri Ülker Center for Metabolic Research and associate member of Harvard-MIT Broad Institute, Harvard Stem Cell Institute and the Joslin Diabetes Center.
David Goltzman is an endocrinologist, Professor of Medicine and Physiology, and A.G. Massabki Chair in Medicine at McGill University in Montreal, Quebec, Canada. He has been the Director of the Centre for Bone and Periodontal Research and also holds the position of Senior Scientist at the McGill University Health Centre Research Institute in the Metabolic Disorders and Complications Program.
John J. M. Bergeron, is a Canadian cell biologist and biochemist. He is an Emeritus Robert Reford Professor of Anatomy and Professor of Medicine at McGill University in Montreal, Quebec, Canada. He is a Rhodes Scholar. He is best known for the discovery of calnexin, endosomal signalling and organellar proteomics.
Barbara B. Kahn is an endocrinologist and the George Richards Minot professor of medicine at Harvard Medical School. She is also the vice chair for research strategy in the department of medicine at Beth Israel Deaconess Medical Center, and was formerly the chief of the Division of Endocrinology, Diabetes, and Metabolism at Beth Israel Deaconess. Her research focuses on insulin resistance and type 2 diabetes.
References
- url=http://www.genomequebec.com/v2009/chercheurs/index.asp?l=e Genome Quebec Retrieved October 2010.