Brensocatib

Last updated

Brensocatib
Brensocatib.svg
Clinical data
Trade names Brinsupri
Other namesAZD7986; INS1007
AHFS/Drugs.com Brinsupri
License data
Routes of
administration 		By mouth
Drug class Dipeptidyl peptidase 1 inhibitor
ATC code
  • None
Legal status
Legal status
Identifiers
  • (2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
Formula C23H24N4O4
Molar mass 420.469 g·mol−1
3D model (JSmol)
  • CN1C2=C(C=CC(=C2)C3=CC=C(C=C3)C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)OC1=O
  • InChI=1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1
  • Key:AEXFXNFMSAAELR-RXVVDRJESA-N

Brensocatib, sold under the brand name Brinsupri, is a medication used for the treatment of bronchiectasis. [1] It is a dipeptidyl peptidase 1 (DPP1) inhibitor. [1] [2] It is taken by mouth. [1]

Contents

Brensocatib was approved for medical use in the United States in August 2025. [1] [3]

Medical uses

Brensocatib is indicated for the treatment of non-cystic fibrosis bronchiectasis in people aged twelve years of age and older. [1]

History

Bresocatib was discovered as a second generation DPP1 inhibitor, by scientists at AstraZeneca, eliminating aorta binding liabilities found with earlier compound series. [4] A phase III clinical trial, known as the ASPEN trial, was conducted to evaluate the safety and efficacy of brensocatib in patients with non-cystic fibrosis bronchiectasis. [5]

Society and culture

Brensocatib was approved for medical use in the United States in August 2025. [6]

In October 2025, the Committee for Medicinal Products for Human Use of the European Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Brinsupri, intended for the treatment of non-cystic fibrosis bronchiectasis in people aged twelve years of age and older. [7] [8] The applicant for Brinsupri is Insmed Netherlands B.V. [9]

Names

Brensocatib is the international nonproprietary name. [10]

Brensocatib is sold under the brand name Brinsupri. [1]

References

  1. 1 2 3 4 5 6 7 https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/217673s000lbl.pdf [ bare URL PDF ]
  2. ↑ Chalmers JD, Usansky H, Rubino CM, Teper A, Fernandez C, Zou J, et al. (October 2022). "Pharmacokinetic/Pharmacodynamic Evaluation of the Dipeptidyl Peptidase 1 Inhibitor Brensocatib for Non-cystic Fibrosis Bronchiectasis". Clinical Pharmacokinetics. 61 (10): 1457–1469. doi:10.1007/s40262-022-01147-w. PMC   9553789 . PMID   35976570.
  3. ↑ "Novel Drug Approvals for 2025". U.S. Food and Drug Administration (FDA). 15 August 2025. Retrieved 17 August 2025.
  4. ↑ Doyle K, Lönn H, Käck H, Van de Poël A, Swallow S, Gardiner P, et al. (October 2015). "Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986)". Journal of Medicinal Chemistry . 59 (20): 9457–9472. doi:10.1021/acs.jmedchem.6b01127. PMID   27690432.
  5. ↑ Chalmers JD, Burgel PR, Daley CL, De Soyza A, Haworth CS, Mauger D, et al. (April 2025). "Phase 3 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis". The New England Journal of Medicine . 392 (16): 1569–1581. doi:10.1056/NEJMoa2411664. PMID   40267423.
  6. ↑ "FDA Approves Brinsupri (brensocatib) as the First and Only Treatment for Non-Cystic Fibrosis Bronchiectasis, a Serious, Chronic Lung Disease" (Press release). Insmed. 12 August 2025. Retrieved 17 August 2025– via PR Newswire.
  7. ↑ "Brinsupri EPAR". European Medicines Agency (EMA). 17 October 2025. Retrieved 27 October 2025. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  8. ↑ "First treatment for serious chronic lung disease". European Medicines Agency (EMA) (Press release). 17 October 2025. Retrieved 27 October 2025.
  9. ↑ "Meeting highlights from the Committee for Medicinal Products for Human Use (CHMP) 13-16 October 2025". European Medicines Agency (EMA). 17 October 2025. Retrieved 27 October 2025.
  10. ↑ World Health Organization (2020). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 83". WHO Drug Information. 34 (1). hdl: 10665/339768 .
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