Bryan Clarke | |
---|---|
![]() | |
Born | Bryan Campbell Clarke 24 June 1932 |
Died | 27 February 2014 81) | (aged
Alma mater | University of Oxford (BA, DPhil) |
Spouse | Ann Clarke (née Jewkes) [1] |
Children | One daughter, Alex; one son, Peter |
Awards | Linnean Medal (2003) Darwin-Wallace Medal (2008) Darwin Medal (2010) |
Scientific career | |
Fields | Genetics, evolutionary biology |
Institutions | University of Nottingham University of Edinburgh |
Thesis | Some factors affecting shell colour polymorphism in Cepaea (1961) |
Doctoral advisor | Arthur Cain |
Doctoral students | |
Other notable students | Fred W. Allendorf |
Bryan Campbell Clarke FRS [3] (24 June 1932 – 27 February 2014) was a British Professor of genetics, latterly emeritus at the University of Nottingham. Clarke is particularly noted for his work on apostatic selection (which is a term he coined in 1962) and other forms of frequency-dependent selection, and work on polymorphism in snails, much of it done during the 1960s. Later, he studied molecular evolution. He made the case for natural selection as an important factor in the maintenance of molecular variation, and in driving evolutionary changes in molecules through time. In doing so, he questioned the over-riding importance of random genetic drift advocated by King, Jukes, and Kimura. With Professor James J Murray Jnr (University of Virginia), he carried out an extensive series of studies on speciation in land snails of the genus Partula inhabiting the volcanic islands of the Eastern Pacific. These studies helped illuminate the genetic changes that take place during the origin of species.
Clarke was educated at Magdalen College, Oxford, receiving a Bachelor of Arts degree in 1956 [1] followed by a Doctor of Philosophy degree in 1961 from the University of Oxford for research investigating factors affecting shell colour polymorphism in the land snails ( Cepaea ). [4]
Clarke was appointed a Lecturer at the University of Edinburgh in 1959 [1] and was promoted to Reader by the time he left in 1971. In 1971 he became Foundation Professor at the new Department of Genetics at the University of Nottingham becoming Emeritus Professor in 1997. During this period he spent two spells (1971–76, 1981–93) as Head of Department.
Clarke mentored many scientists in evolutionary genetics, supervising more than thirty research students, many of which went gone on to successful research careers themselves such as Steve Jones. [2] He was a co-founder of the Population Genetics Group ("PopGroup") a scientific meeting for evolutionary and population genetics held annually in the UK since the 1960s. [5]
Clarke was co-founder (with his wife Ann and Dame Anne McLaren) and trustee of the Frozen Ark project, launched in 2004 to preserve the DNA and living cells of endangered species worldwide. [6] [7]
Clarke acted as managing editor of the scientific journal Heredity from 1978 to 1985. [7]
Clarke was elected a Fellow of the Royal Society in 1982. [1] In 2003 he was both awarded the Linnean Medal for Zoology and elected a Foreign member of the American Philosophical Society. In 2004 he was elected a Foreign Honorary Member of the American Academy of Arts and Sciences. He received one of the thirteen Darwin-Wallace Medals awarded by the Linnean Society of London in 2008; at that time the award was made only every 50 years. [8] He was awarded the Darwin Medal of the Royal Society in 2010 'for his original and influential contributions to our understanding of the genetic basis of evolution'. [9]
In 1959 he published Berber Village, an account of an Oxford University expedition to the High Atlas mountains of Morocco. [10]
John Maynard Smith was a British theoretical and mathematical evolutionary biologist and geneticist. Originally an aeronautical engineer during the Second World War, he took a second degree in genetics under the biologist J. B. S. Haldane. Maynard Smith was instrumental in the application of game theory to evolution with George R. Price, and theorised on other problems such as the evolution of sex and signalling theory.
John Stephen JonesDSc FLSW is a British geneticist and, from 1995 to 1999 as well as from 2008 to June 2010, was Head of the Department of Genetics, Evolution and Environment at University College London. His studies are conducted in the Galton Laboratory.
Edmund Brisco "Henry" Ford was a British ecological geneticist. He was a leader among those British biologists who investigated the role of natural selection in nature. As a schoolboy Ford became interested in lepidoptera, the group of insects which includes butterflies and moths. He went on to study the genetics of natural populations, and invented the field of ecological genetics. Ford was awarded the Royal Society's Darwin Medal in 1954. In the wider world his best known work is Butterflies (1945). Ford was a member of the UK Eugenics Society, of which he was a council member in 1933-1934, also contributing to its publications.
In biology, polymorphism is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species. To be classified as such, morphs must occupy the same habitat at the same time and belong to a panmictic population.
The Genetical Theory of Natural Selection is a book by Ronald Fisher which combines Mendelian genetics with Charles Darwin's theory of natural selection, with Fisher being the first to argue that "Mendelism therefore validates Darwinism" and stating with regard to mutations that "The vast majority of large mutations are deleterious; small mutations are both far more frequent and more likely to be useful", thus refuting orthogenesis. First published in 1930 by The Clarendon Press, it is one of the most important books of the modern synthesis, and helped define population genetics. It had been described by J. F. Crow as the "deepest book on evolution since Darwin".
Frequency-dependent selection is an evolutionary process by which the fitness of a phenotype or genotype depends on the phenotype or genotype composition of a given population.
Professor Philip MacDonald Sheppard, F.R.S. was a British geneticist and lepidopterist. He made advances in ecological and population genetics in lepidopterans, pulmonate land snails and humans. In medical genetics, he worked with Cyril Clarke on Rh disease.
Balancing selection refers to a number of selective processes by which multiple alleles are actively maintained in the gene pool of a population at frequencies larger than expected from genetic drift alone. Balancing selection is rare compared to purifying selection. It can occur by various mechanisms, in particular, when the heterozygotes for the alleles under consideration have a higher fitness than the homozygote. In this way genetic polymorphism is conserved.
Arthur James Cain FRS was a British evolutionary biologist and ecologist. He was elected a Fellow of the Royal Society in 1989.
The grove snail, brown-lipped snail or lemon snail is a species of air-breathing land snail, a terrestrial pulmonate gastropod mollusc.
Brian Charlesworth is a British evolutionary biologist at the University of Edinburgh, and editor of Biology Letters. Since 1997, he has been Royal Society Research Professor at the Institute of Evolutionary Biology (IEB) in Edinburgh. He has been married since 1967 to the British evolutionary biologist Deborah Charlesworth.
Sir Edward Bagnall Poulton, FRS HFRSE FLS was a British evolutionary biologist, a lifelong advocate of natural selection through a period in which many scientists such as Reginald Punnett doubted its importance. He invented the term sympatric for evolution of species in the same place, and in his book The Colours of Animals (1890) was the first to recognise frequency-dependent selection. He is remembered for his pioneering work on animal coloration and camouflage, and in particular for inventing the term aposematism for warning coloration. He became Hope Professor of Zoology at the University of Oxford in 1893.
Gabriel A. Dover was a British geneticist, best known for coining the term molecular drive in 1982 to describe a putative third evolutionary force operating distinctly from natural selection and genetic drift.
Cepaea is a genus of large air-breathing land snails, terrestrial pulmonate gastropod molluscs in the family Helicidae. The shells are often brightly coloured and patterned with brown stripes. The two species in this genus, C. nemoralis and C. hortensis, are widespread and common in Western and Central Europe and have been introduced to North America. Both have been influential model species for ongoing studies of genetics and natural selection. Like many Helicidae, these snails use love darts during mating.
Paul H. Harvey is a British evolutionary biologist. He is Professor of Zoology and was head of the zoology department at the University of Oxford from 1998 to 2011 and Secretary of the Zoological Society of London from 2000 to 2011, holding these posts in conjunction with a professorial fellowship at Jesus College, Oxford.
Alan Robertson was an English population geneticist. Originally a chemist, he was recruited after the Second World War to work on animal genetics on behalf of the British government, and continued in this sphere until his retirement in 1985. He was a major influence in the widespread adoption of artificial insemination of cattle.
William George Hill was an English geneticist and statistician. He was a professor at University of Edinburgh. He is credited as co-discoverer of the Hill–Robertson effect with his doctoral advisor, Alan Robertson.
Beverley Jane Glover is a British biologist specialising in botany. Since July 2013, she has been Professor of Plant Systematics and Evolution in the Department of Plant Sciences at the University of Cambridge and director of the Cambridge University Botanic Garden.
Josephine M. Pemberton is a British evolutionary biologist. She is Chair of Natural History at the University of Edinburgh, where she conducts research in parentage analysis, pedigree reconstruction, inbreeding depression, parasite resistance, and quantitative trait locus (QTL) detection in natural populations. She has worked primarily on long-term studies of soay sheep on St Kilda, and red deer on the island of Rùm.