CAB39

CAB39
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1UPK, 1UPL, 2WTK, 3GNI, 4FZA, 4FZD, 4FZF, 4NZW, 4O27 Contents References ; External links ; Further reading ;
Identifiers
Aliases	CAB39 , MO25, CGI-66, calcium binding protein 39
External IDs	OMIM: 612174 MGI: 107438 HomoloGene: 69212 GeneCards: CAB39
Gene location (Human)
Chr.	Chromosome 2 (human)
End	230,821,075 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	85,779,297 bp
RNA expression pattern
	Top expressed in
	amniotic fluid; ; tibia; ; middle temporal gyrus; ; palpebral conjunctiva; ; triceps brachii muscle; ; internal globus pallidus; ; cavity of mouth; ; cancellous bone; ; muscle of leg; ; gastrocnemius muscle;
	Top expressed in
	facial motor nucleus; ; anterior horn of spinal cord; ; plantaris muscle; ; soleus muscle; ; extensor digitorum longus muscle; ; gastrocnemius muscle; ; parotid gland; ; tibialis anterior muscle; ; intercostal muscle; ; digastric muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein serine/threonine kinase activator activity ; protein kinase activator activity ; protein serine/threonine kinase activity ; kinase binding ; protein binding ;
Cellular component	cytoplasm ; cytosol ; serine/threonine protein kinase complex ; extracellular exosome ; extracellular region ; secretory granule lumen ; ficolin-1-rich granule lumen ; protein-containing complex ;
Biological process	intracellular signal transduction ; protein heterooligomerization ; signal transduction ; cellular hypotonic response ; positive regulation of protein serine/threonine kinase activity ; negative regulation of potassium ion transmembrane transporter activity ; positive regulation of peptidyl-threonine phosphorylation ; peptidyl-serine phosphorylation ; negative regulation of potassium ion transmembrane transport ; activation of protein kinase activity ; neutrophil degranulation ;
	Sources:Amigo / QuickGO
Orthologs
	51719
	12283
	ENSG00000135932
	ENSMUSG00000036707
	Q9Y376
	Q06138
	NM_001130849 ; NM_001130850 ; NM_016289
	NM_133781 ; NM_001355046 ; NM_001355047
	NP_001124321 ; NP_001124322 ; NP_057373
	NP_598542 ; NP_001341975 ; NP_001341976
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.^[5]

The protein encoded by this gene associates with STK11 (Serine/Threonine Kinase 11) and STRAD (STE20-Related ADaptor protein).^[6] CAB39 enhances formation of STK11/STRAD complexes and stimulates STK11 catalytic activity. CAB39 may function as a scaffolding component of the STK11/STRAD complex and regulates STK11 activity and cellular localization.^[6]

Related Research Articles

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Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135932 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036707 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CAB39 calcium binding protein 39".
1 2 Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR (October 2003). "MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473 . PMID 14517248.

External links

Human CAB39 genome location and CAB39 gene details page in the UCSC Genome Browser .

Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity". Trends Cell Biol. 14 (6): 312–9. doi:10.1016/j.tcb.2004.04.001. PMID 15183188.
Hawley SA, Davison M, Woods A, et al. (1996). "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase". J. Biol. Chem. 271 (44): 27879–87. doi: 10.1074/jbc.271.44.27879 . PMID 8910387.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876 . PMID 10810093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Boudeau J, Baas AF, Deak M, et al. (2003). "MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473 . PMID 14517248.
Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi: 10.1074/jbc.M312171200 . PMID 14676191.
Milburn CC, Boudeau J, Deak M, et al. (2004). "Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor". Nat. Struct. Mol. Biol. 11 (2): 193–200. doi:10.1038/nsmb716. PMID 14730349. S2CID 18401688.
Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014 . PMID 14976552.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Boudeau J, Scott JW, Resta N, et al. (2005). "Analysis of the LKB1-STRAD-MO25 complex". J. Cell Sci. 117 (Pt 26): 6365–75. doi: 10.1242/jcs.01571 . PMID 15561763.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135932 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036707 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CAB39 calcium binding protein 39".

[pmid14517248-6] 1 2 Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR (October 2003). "MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm". EMBO J. 22 (19): 5102–14. doi:10.1093/emboj/cdg490. PMC 204473 . PMID 14517248.

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CAB39

Contents

Related Research Articles

References

External links

Further reading