| CCDC82 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | CCDC82 , HSPC048, coiled-coil domain containing 82 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 1913646 HomoloGene: 11678 GeneCards: CCDC82 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Coiled-Coil Domain Containing protein 82 (CCDC82) is a protein that in humans, is encoded for by the gene of the same name, CCDC82. The CCDC82 gene is expressed in nearly all of human tissues at somewhat low rates. As of today, there are no patents involving CCDC82 and the function remains unknown.
CCDC82 is located on chromosome 11 at 11q21.5. [5] It contains two domains of unknown function, DUF4196 and DUF4211. [6] The DNA sequence is 37,155 base pairs long [7] and contains 7 exons. [8]
CCDC82 is present in many orthologs. It is conserved throughout other mammals, reptiles, birds and bony fish. It is not found in invertebrates, bacteria or fungi. There are no paralogs. [9]
| Scientific name | Common name | Date of divergence | Accession number | Length | Percent identity | Percent similarity |
|---|---|---|---|---|---|---|
| Pan troglodytes | Chimpanzee | 6.3 Mya | XP_001147806.1 | 544 aa | 60.8 | 99 |
| Gorilla gorilla gorilla | Gorilla | 8.8 Mya | XP_004052053.1 | 521 aa | 56.2 | 91 |
| Pongo pygmaeus | Orangutan | 15.7 Mya | NP_003253075.1 | 343 aa | 95.3 | 98 |
| Nomascus leucogenys | Crested gibbon | 20.4 Mya | XP_003253075.1 | 554 aa | 57.8 | 94 |
| Papio anubis | Olive baboon | 29 Mya | XP_003910631.1 | 542 aa | 52 | 86 |
| Callithrix jacchus | Marmoset | 42.6 Mya | XP_002754732.1 | 526 aa | 51.2 | 86 |
| Mus musculus | Mouse | 92.3 Mya | NP_079810.2 | 518 aa | 39.7 | 74 |
| Rattus norvegicus | Brown rat | 92.3 Mya | NP_001007661.1 | 516 aa | 37.4 | 71 |
| Canis lupus familiaris | Dog | 94.2 Mya | XP_542232.2 | 520 aa | 46 | 79 |
| Bos taurus | Cow | 94.2 Mya | NP_001039559.2 | 522 aa | 42.4 | 74 |
| Ailuropoda melanoleuca | Giant panda | 94.2 Mya | XP_002925755.1 | 528 aa | 45.4 | 80 |
| Loxodonta africana | African bush elephant | 98.7 Mya | XP_003415705.1 | 521 aa | 40.4 | 75 |
| Sarcophilus harrisii | Tasmanian devil | 162.2 Mya | XP_003764344.1 | 518 aa | 36.9 | 70 |
| Monodelphis domestica | Gray short-tailed opossum | 162.2 Mya | XP_001363143.1 | 516 aa | 36.7 | 72 |
| Ornithorhynchus anatinus | Platypus | 167.4 Mya | XP_001511067.1 | 505 aa | 26.6 | 70 |
| Gallus gallus | Chicken | 296 Mya | XP_423807.3 | 460 aa | 24.3 | 56 |
| Meleagris gallopavo | Wild turkey | 296 Mya | XP_003203546.1 | 462 aa | 21.5 | 70 |
| Taeniopygia guttata | Zebra finch | 296 Mya | XP_002198267.1 | 575 aa | 20 | 61 |
| Anolis carolinensis | Carolina anole | 296 Mya | XP_003219357.1 | 603 aa | 19.9 | 49 |
| Xenopus tropicalis | Western clawed frog | 371.2 Mya | XP_002935613.1 | 462 aa | 21 | 73 |
The predicted promoter for CCDC82 is located on the minus strand and spans from base pairs 96,122,963 to 96,123,587. It is 625 base pairs long. [10]
The transcription factors listed below are for the predicted promoter sequence and are located on the minus strand. [11]
| Detailed Family Information | Span | Score |
|---|---|---|
| Alternative splicing variant of FOXP1 | 48-64 | 1.00 |
| Homeodomain transcription factor Otx2 | 34-50 | .992 |
| Hypoxia-response Elements | 111-127 | .985 |
| Homeobox A10/HOX 1.8 | 52-68 | .957 |
| SRY box 9 | 80-104 | .947 |
| Mesoderm posterior 1 and 2 | 42-62 | .937 |
| c-Myc/Max heterodimer | 44-60 | .929 |
| SAM pointed domain containing ets transcription factor | 27-47 | .923 |
| cAMP-responsive element binding protein | 134-154 | .917 |
| PR domain zinc finger protein 14 | 138-152 | .912 |
The protein it encodes for is 344 amino acids in length. The protein itself is very acidic and is very rich in aspartic acid and glutamic acid. It is also very deficient in alanine, containing only two alanines in the entire sequence. The alanines are located adjacent to each other, amino acid number 233 and 234. Alanine 233 is highly conserved throughout the orthologs. The molecular weight is 40.0 kdal and the isoelectric point is 4.383 [12]
CCDC82 is found in nearly all tissues in the human body, however it is present in higher quantities in the skeletal muscles, adrenal cortex, and the trigeminal ganglion. [13] [14]
CCDC82 has several predicted phosphorylation sites. [15] There are 32 predicted serine phosphorylation sites, 5 threonine, and 3 tyrosine. [16]
CCDC82 is known to interact with two proteins. It indirectly interacts with VHL, a gene that encodes for a tumor suppressor and ubiquitin protein ligase. It also interacts with EWSR1, which functions as a transcriptional repressor. [17]
CCDC82 is a circulat-responsive gene. [18] Circulat is a product designed to restore systemic vascular health. It is a plant based product and taken by patients who suffer from diabetes or circulatory problems. [19]
Based on the information that CCDC82 is affected by the Circulat product it could be hypothesized that CCDC82 is involved in circulatory function. However, this is purely speculation.
Coiled-coil domain-containing protein 113 also known as HSPC065, GC16Pof6842 and GC16P044152, is a protein that in humans is encoded by the CCDC113 gene. The human CCDC113 gene is located on chromosome 16q21 and encodes 5,304 base pairs of mRNA and 377 amino acids.
HIKESHI is a protein important in lung and multicellular organismal development that, in humans, is encoded by the HIKESHI gene. HIKESHI is found on chromosome 11 in humans and chromosome 7 in mice. Similar sequences (orthologs) are found in most animal and fungal species. The mouse homolog, lethal gene on chromosome 7 Rinchik 6 protein is encoded by the l7Rn6 gene.
Transmembrane protein 242 (TMEM242) is a protein that in humans is encoded by the TMEM242 gene. The tmem242 gene is located on chromosome 6, on the long arm, in band 2 section 5.3. This protein is also commonly called C6orf35, BM033, and UPF0463 Transmembrane Protein C6orf35. The tmem242 gene is 35,238 base pairs long, and the protein is 141 amino acids in length. The tmem242 gene contains 4 exons. The function of this protein is not well understood by the scientific community. This protein contains a DUF1358 domain.
KIAA0895 is a protein that in Homo sapiens is encoded by the KIAA0895 gene. The gene encodes a protein commonly known as the KIAA0895 protein. It's aliases include hypothetical protein LOC23366, OTTHUMP00000206979, OTTHUMP00000206980, 9530077C05Rik, and 1110003N12Rik. It is located at 7p14.2.
The human gene Chromosome 3 open reading frame 14 is a gene of uncertain function located at 3p14.2 near fragile site FRBA3—which falls between this gene and the centromere. Its protein is expected to localize to the nucleus and bind DNA. Orthologs have been identified in all of the major animal groups, minus amphibians and insects, tracing as far back as the sea anemone; indicating an origin of over 1000 mya, highlighting its importance in the animal genome.
Tetratricopeptide repeat 39A is a human protein encoded by the TTC39A gene. TTC39A is also known as DEME-6, KIAA0452, and c1orf34. The function of TTC39A is currently not well understood. The main feature within tetratricopeptide repeat 39A is the domain of unknown function 3808 (DUF3808), spanning almost the entire protein. KIAA0452 can also be seen as an isoform of TTC39A because of differences in genome sequence, but overlap in DUF domain.
Coiled-coil domain containing 109B (CCDC109B) is a potential calcium uniporter protein found in the membrane of human cells and is encoded by the CCDC109B gene. While CCDC109B is a transmembrane protein it is unclear if it is located within the cell membrane or mitochondrial membrane.
The FAM185A is a protein that in humans is encoded by the FAM185A gene. The FAM185A gene is found on the positive strand of Chromosome 7 at 7q22.1. The gene begins 102,389,399bp from the p-terminus of the chromosome and ends at 102,449,672bp from the p-terminus; it covers a total of 73,308 basepairs. The protein encoded by this gene is characterized by the presence of multiple copies of DUF4098 near its C-terminus. It is described as a Long Interspersed Nuclear Element (LINE), a subclass of penaeid repetitive elements (PREs).
Family with Sequence Similarity 203, Member B (FAM203B) is a protein encoded by the FAM203B gene (8q24.3) in humans. While FAM203B is only found in humans and possibly non-human primates, its paralog, FAM203A, is highly conserved. The FAM203B protein contains two conserved domains of unknown function, DUF383 and DUF384, and no transmembrane domains. This protein has no known function yet, although the homolog of FAM203A in Caenorhabditis elegans (Y54H5A.2) is thought to help regulate the actin cytoskeleton.
Protein FAM214A, also known as protein family with sequence similarity 214, A (FAM214A) is a protein that, in humans, is encoded by the FAM214A gene. FAM214A is a gene with unknown function found at the q21.2-q21.3 locus on Chromosome 15 (human). The protein product of this gene has two conserved domains, one of unknown function (DUF4210) and another one called Chromosome_Seg. Although the function of the FAM214A protein is uncharacterized, both DUF4210 and Chromosome_Seg have been predicted to play a role in chromosome segregation during meiosis.
Coiled-coil domain containing 94 (CCDC94) is a protein that in humans is encoded by the CCDC94 gene. The CCDC94 protein contains a coiled-coil domain, a domain of unknown function (DUF572), an uncharacterized conserved protein (COG5134), and lacks a transmembrane domain.
Transmembrane protein 251, also known as C14orf109 or UPF0694, is a protein that in humans is encoded by the TMEM251 gene. One notable feature of this protein is the presence of proline residues on one of its predicted transmembrane domains., which is a determinant of the intramitochondrial sorting of inner membrane proteins.
Shortage In Chiasmata 1, also known as SHOC1, is a protein that in humans is encoded by the SHOC1 gene.
Uncharacterized protein C2orf73 is a protein that in humans is encoded by the C2orf73 gene. The protein is predicted to be localized to the nucleus.
Chromosome 9 open reading frame 43 is a protein that in humans is encoded by the C9orf43 gene. The gene is also known as MGC17358 and LOC257169. C9orf43 contains DUF 4647 and a polyglutamine repeat region although protein function is not well understood.
C12orf24 is a gene in humans that encodes a protein known as FAM216A. This gene is primarily expressed in the testis and brain, but has constitutive expression in 25 other tissues. FAM216A is an intracellular protein that has been predicted to reside within the nucleus of cells. The exact function of C12orf24 is unknown. FAM216A is highly expressed in Sertoli cells of the testis as well as different stage spermatids.
ProteinFAM89A is a protein which in humans is encoded by the FAM89A gene. It is also known as chromosome 1 open reading frame 153 (C1orf153). Highest FAM89A gene expression is observed in the placenta and adipose tissue. Though its function is largely unknown, FAM89A is found to be differentially expressed in response to interleukin exposure, and it is implicated in immune responses pathways and various pathologies such as atherosclerosis and glioma cell expression.
TMEM275 is a protein that in humans is encoded by the TMEM275 gene. TMEM275 has two, highly-conserved, helical trans-membrane regions. It is predicted to reside within the plasma membrane or the endoplasmic reticulum's membrane.
PANO1 is a protein which in humans is encoded by the PANO1 gene. PANO1 is an apoptosis inducing protein that is able to regulate the function of tumor suppressor. More specifically, P14ARF is a protein in which in humans is modulated by the PANO1 gene. P14ARF is known to function as a tumor suppressor. When PANO1 is highly expressed in the cells, it is able to modulate p14ARF by stabilizing it and protecting it from degradation. With a confidence level of 5 out of 5, PANO1 has been theorized to be expressed in the nucleolus of the cell. PANO1 is an intron-less gene. Intron-less genes only make up about 3% of the human genome. A functional analysis of these types of genes revealed that they often have tissue-specific expression in tissues such as the nervous system and testis. This kind of expression is commonly associated with neuropathies, disease, and cancer. The tissue types that PANO1 has the highest expression in, are the cerebellum regions of the brain as well as pituitary and testis tissues.
C11orf98 is a protein-encoding gene on chromosome 11 in humans of unknown function. It is otherwise known as c11orf48. The gene spans the chromosomal locus from 62,662,817-62,665,210. There are 4 exons. It spans across 2,394 base pairs of DNA and produces an mRNA that is 646 base pairs long.
