CCNG1

CCNG1
Identifiers
Aliases	CCNG1 , cyclin G1, CCNG
External IDs	OMIM: 601578 MGI: 102890 HomoloGene: 2995 GeneCards: CCNG1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	163,446,151 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	40,646,138 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; jejunal mucosa; ; kidney tubule; ; corpus epididymis; ; vastus lateralis muscle; ; deltoid muscle; ; parotid gland; ; kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GO:0001948 protein binding ; protein kinase activity ; cyclin-dependent protein serine/threonine kinase regulator activity ; protein kinase binding ;
Cellular component	nucleus ; nucleoplasm ; cyclin-dependent protein kinase holoenzyme complex ; cytoplasm ;
Biological process	cell cycle ; regulation of cyclin-dependent protein serine/threonine kinase activity ; regulation of cell cycle ; cell division ; GO:0007067 mitotic cell cycle ; protein phosphorylation ; regulation of mitotic nuclear division ; positive regulation of cell population proliferation ; positive regulation of cell cycle ; GO:0007090 mitotic cell cycle phase transition ;
	Sources:Amigo / QuickGO
Orthologs
	900
	12450
	ENSG00000113328
	ENSMUSG00000020326
	P51959
	P51945
	NM_004060 ; NM_199246
	NM_009831
NP_004051 ; NP_954854 ; NP_001350944 ; NP_001350947 ; NP_001350948 ;
	NP_001350949 ; NP_001350950 ; NP_001350951 ; NP_001350952 Contents Function ; Interactions ; References ; External links ; Further reading ;
	NP_033961
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2022

Cyclin-G1 is a protein that in humans is encoded by the CCNG1 gene.^[5]^[6]^[7]

Function

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene.^[7]

Interactions

CCNG1 has been shown to interact with:

Related Research Articles

Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. CDK4 is a member of the cyclin-dependent kinase family.

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. In humans, Cdk1 is encoded by the CDC2 gene. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates ; phosphorylation of these proteins leads to cell cycle progression.

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

G1/S-specific cyclin-D3 is a protein that in humans is encoded by the CCND3 gene.

M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.

G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene.

Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene.

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.

Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.

PITSLRE serine/threonine-protein kinase CDC2L1 is an enzyme that in humans is encoded by the CDC2L1 gene.

Cyclin-C is a protein that in humans is encoded by the CCNC gene.

Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.

Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.

Cyclin-G2 is a protein that in humans is encoded by the CCNG2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113328 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020326 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Endo Y, Fujita T, Tamura K, Tsuruga H, Nojima H (1996). "Structure and chromosomal assignment of the human cyclin G gene". Genomics. 38 (1): 92–5. doi:10.1006/geno.1996.0598. PMID 8954786.
↑ Bates S, Rowan S, Vousden KH (Nov 1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene. 13 (5): 1103–9. PMID 8806701.
1 2 "Entrez Gene: CCNG1 cyclin G1".
1 2 3 Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC, Quelle DE (Jan 2003). "Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways". Mol. Cancer Res. 1 (3): 195–206. PMID 12556559.
↑ Okamoto K, Kamibayashi C, Serrano M, Prives C, Mumby MC, Beach D (Nov 1996). "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A". Mol. Cell. Biol. 16 (11): 6593–602. doi:10.1128/mcb.16.11.6593. PMC 231661 . PMID 8887688.

External links

Human CCNG1 genome location and CCNG1 gene details page in the UCSC Genome Browser .

Horne MC, Goolsby GL, Donaldson KL, Tran D, Neubauer M, Wahl AF (1996). "Cyclin G1 and cyclin G2 comprise a new family of cyclins with contrasting tissue-specific and cell cycle-regulated expression". J. Biol. Chem. 271 (11): 6050–61. doi: 10.1074/jbc.271.11.6050 . PMID 8626390.
Kanaoka Y, Kimura SH, Okazaki I, Ikeda M, Nojima H (1997). "GAK: a cyclin G associated kinase contains a tensin/auxilin-like domain". FEBS Lett. 402 (1): 73–80. doi: 10.1016/S0014-5793(96)01484-6 . PMID 9013862. S2CID 22697554.
Kato MV (1999). "The mechanisms of death of an erythroleukemic cell line by p53: involvement of the microtubule and mitochondria". Leuk. Lymphoma. 33 (1–2): 181–6. doi:10.3109/10428199909093740. PMID 10194136.
Reimer CL, Borras AM, Kurdistani SK, Garreau JR, Chung M, Aaronson SA, Lee SW (1999). "Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells". J. Biol. Chem. 274 (16): 11022–9. doi: 10.1074/jbc.274.16.11022 . PMID 10196184.
Bennin DA, Don AS, Brake T, McKenzie JL, Rosenbaum H, Ortiz L, DePaoli-Roach AA, Horne MC (2002). "Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest". J. Biol. Chem. 277 (30): 27449–67. doi: 10.1074/jbc.M111693200 . PMID 11956189.
Jordan-Sciutto KL, Morgan K, Bowser R (1999). "Increased Cyclin G1 Immunoreactivity During Alzheimer's Disease". J. Alzheimers Dis. 1 (6): 409–417. doi:10.3233/jad-1999-1605. PMID 12214116.
Baek WK, Kim D, Jung N, Yi YW, Kim JM, Cha SD, Bae I, Cho CH (2003). "Increased expression of cyclin G1 in leiomyoma compared with normal myometrium". Am. J. Obstet. Gynecol. 188 (3): 634–9. doi:10.1067/mob.2003.140. PMID 12634633.
Li JQ, Kubo A, Wu F, Usuki H, Fujita J, Bandoh S, Masaki T, Saoo K, Takeuchi H, Kobayashi S, Imaida K, Maeta H, Ishida T, Kuriyama S (2003). "Cyclin B1, unlike cyclin G1, increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes". Int. J. Oncol. 22 (5): 1101–10. doi:10.3892/ijo.22.5.1101. PMID 12684677.
Ohtsuka T, Jensen MR, Kim HG, Kim KT, Lee SW (2004). "The negative role of cyclin G in ATM-dependent p53 activation". Oncogene. 23 (31): 5405–8. doi: 10.1038/sj.onc.1207693 . PMID 15077171.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Seo HR, Lee DH, Lee HJ, Baek M, Bae S, Soh JW, Lee SJ, Kim J, Lee YS (2006). "Cyclin G1 overcomes radiation-induced G2 arrest and increases cell death through transcriptional activation of cyclin B1". Cell Death Differ. 13 (9): 1475–84. doi: 10.1038/sj.cdd.4401822 . PMID 16322753.
Gramantieri L, Ferracin M, Fornari F, Veronese A, Sabbioni S, Liu CG, Calin GA, Giovannini C, Ferrazzi E, Grazi GL, Croce CM, Bolondi L, Negrini M (2007). "Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma". Cancer Res. 67 (13): 6092–9. doi: 10.1158/0008-5472.CAN-06-4607 . PMID 17616664.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000113328 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020326 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8954786-5] Endo Y, Fujita T, Tamura K, Tsuruga H, Nojima H (1996). "Structure and chromosomal assignment of the human cyclin G gene". Genomics. 38 (1): 92–5. doi:10.1006/geno.1996.0598. PMID 8954786.

[pmid8806701-6] Bates S, Rowan S, Vousden KH (Nov 1996). "Characterisation of human cyclin G1 and G2: DNA damage inducible genes". Oncogene. 13 (5): 1103–9. PMID 8806701.

[entrez-7] 1 2 "Entrez Gene: CCNG1 cyclin G1".

[pmid12556559-8] 1 2 3 Zhao L, Samuels T, Winckler S, Korgaonkar C, Tompkins V, Horne MC, Quelle DE (Jan 2003). "Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways". Mol. Cancer Res. 1 (3): 195–206. PMID 12556559.

[pmid8887688-9] Okamoto K, Kamibayashi C, Serrano M, Prives C, Mumby MC, Beach D (Nov 1996). "p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A". Mol. Cell. Biol. 16 (11): 6593–602. doi:10.1128/mcb.16.11.6593. PMC 231661 . PMID 8887688.

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