CDC23

CDC23
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 5A31, 5G05, 5G04
Identifiers
Aliases	CDC23 , ANAPC8, APC8, CUT23, cell division cycle 23
External IDs	OMIM: 603462; MGI: 1098815; HomoloGene: 3426; GeneCards: CDC23; OMA:CDC23 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	138,213,343 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	34,784,788 bp
RNA expression pattern
	Top expressed in
	gonad; ; ventricular zone; ; tibia; ; endothelial cell; ; rectum; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; ovary; ; islet of Langerhans; ; left ovary;
	Top expressed in
	genital tubercle; ; tail of embryo; ; ventricular zone; ; mandibular prominence; ; medullary collecting duct; ; superior cervical ganglion; ; maxillary prominence; ; abdominal wall; ; ganglionic eminence; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-protein transferase activity ; protein binding ;
Cellular component	nucleoplasm ; cytosol ; intracellular anatomical structure ; anaphase-promoting complex ;
Biological process	ubiquitin-dependent protein catabolic process ; regulation of exit from mitosis ; regulation of mitotic metaphase/anaphase transition ; cell cycle ; cell division ; protein K11-linked ubiquitination ; metaphase ; anaphase-promoting complex-dependent catabolic process ; protein ubiquitination ; mitotic metaphase plate congression ; mitotic cell cycle ; regulation of mitotic cell cycle phase transition ;
	Sources:Amigo / QuickGO
Orthologs
	8697
	52563
	ENSG00000094880
	ENSMUSG00000024370
	Q9UJX2
	Q8BGZ4
	NM_004661
	NM_178347
	NP_004652
	NP_848124
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 15, 2024

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.^[5]

Function

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.^[5]

Interactions

CDC23 has been shown to interact with CDC27.^[6]^[7]

Related Research Articles

Anaphase-promoting complex is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF. Other parts of the APC/C have unknown functions but are highly conserved.

Cyclin-dependent kinase 4 also known as cell division protein kinase 4 is an enzyme that in humans is encoded by the CDK4 gene. CDK4 is a member of the cyclin-dependent kinase family.

<span class="mw-page-title-main">CDC20</span> Protein-coding gene in humans

The cell division cycle protein 20 homolog is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/C^Cdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.

Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.

Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene.

Cell division protein kinase 8 is an enzyme that in humans is encoded by the CDK8 gene.

F-box only protein 5 is a protein that in humans is encoded by the FBXO5 gene.

Fizzy-related protein homolog, also known as hCDH1, is a protein that in humans is encoded by the FZR1 gene.

Cell division cycle protein 16 homolog is a protein that in humans is encoded by the CDC16 gene.

Anaphase-promoting complex subunit 1 is an enzyme that in humans is encoded by the ANAPC1 gene.

Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.

Cohesin subunit SA-2 (SA2) is a protein that in humans is encoded by the STAG2 gene. SA2 is a subunit of the Cohesin complex which mediates sister chromatid cohesion, homologous recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B, REC8 and SA3.

Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.

Sister chromatid cohesion protein PDS5 homolog A is a protein that in humans is encoded by the PDS5A gene.

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.

<span class="mw-page-title-main">APC/C activator protein CDH1</span> Fungal protein found in Saccharomyces cerevisiae S288c

Cdh1 is one of the substrate adaptor proteins of the anaphase-promoting complex (APC) in the budding yeast Saccharomyces cerevisiae. Functioning as an activator of the APC/C, Cdh1 regulates the activity and substrate specificity of this ubiquitin E3-ligase. The human homolog is encoded by the FZR1 gene, which is not to be confused with the CDH1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000094880 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024370 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)".
↑ Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi: 10.1016/S0960-9822(03)00581-5 . PMID 12956947.
↑ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . PMC 16806 . PMID 10922056.

External links

Human CDC23 genome location and CDC23 gene details page in the UCSC Genome Browser .

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000094880 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024370 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)".

[pmid12956947-6] Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi: 10.1016/S0960-9822(03)00581-5 . PMID 12956947.

[pmid10922056-7] Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi: 10.1073/pnas.97.16.8973 . PMC 16806 . PMID 10922056.

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