CPSF7

CPSF7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3N9U
Identifiers
Aliases	CPSF7 , CFIm59, FLJ12529, cleavage and polyadenylation specific factor 7
External IDs	MGI: 1917826 HomoloGene: 11731 GeneCards: CPSF7
Gene location (Human)
Chr.	Chromosome 11 (human)
End	61,430,031 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	10,525,017 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right uterine tube; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; canal of the cervix; ; gastric mucosa; ; right coronary artery; ; popliteal artery; ; body of pancreas; ; left uterine tube;
	Top expressed in
	thymus; ; superior surface of tongue; ; median eminence; ; paraventricular nucleus of hypothalamus; ; maxillary prominence; ; arcuate nucleus; ; ventromedial nucleus; ; ciliary body; ; cerebellar cortex; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; nucleic acid binding ; RNA binding ;
Cellular component	membrane ; nucleus ; nucleoplasm ; mRNA cleavage factor complex ; cytoplasm ; mRNA cleavage and polyadenylation specificity factor complex ;
Biological process	mRNA splicing, via spliceosome ; termination of RNA polymerase II transcription ; mRNA processing ; mRNA 3'-end processing ; protein tetramerization ; protein heterotetramerization ; pre-mRNA cleavage required for polyadenylation ; mRNA alternative polyadenylation ; messenger ribonucleoprotein complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	79869
	269061
	ENSG00000149532
	ENSMUSG00000034820
	Q8N684
	Q8BTV2
	NM_001136040 ; NM_001142565 ; NM_024811
	NM_001164272 ; NM_172302 ; NM_001362450
	NP_001129512 ; NP_001136037 ; NP_079087
	NP_001157744 ; NP_758506 ; NP_001349379
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 14, 2024

Cleavage and polyadenylation specificity factor subunit 7 is a protein that in humans is encoded by the CPSF7 gene.^[5]^[6]

Function

CPSF7, also known as CFIm59, is the cleavage factor of two closely associated protein complexes in the 3' untranslated region of a newly synthesized pre-messenger RNA (mRNA) molecule used in gene transcription. ^[7] CPSF7 is one of three Cleavage and polyadenylation specificity factors (CPSF), the other two being CFIm25 (or CPSF5/NUDT21) and CFIm68 (or CPSF6).

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000149532 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034820 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
↑ "Entrez Gene: FLJ12529 pre-mRNA cleavage factor I, 59 kDa subunit".
↑ Hardy JG, Norbury CJ (August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–7. doi:10.1042/BST20160078. PMID 27528751. S2CID 206156045.

CPSF7

Contents

Function

Related Research Articles

References

Further reading