CPSF7

CPSF7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3N9U
Identifiers
Aliases	CPSF7 , CFIm59, FLJ12529, cleavage and polyadenylation specific factor 7
External IDs	MGI: 1917826; HomoloGene: 11731; GeneCards: CPSF7; OMA:CPSF7 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q12.2 Start 61,402,641 bp [1] End 61,430,031 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 10,502,630 bp [2] End 10,525,017 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary right uterine tube right lobe of thyroid gland left lobe of thyroid gland body of uterus left ovary canal of the cervix right ovary ventricular zone gastric mucosa Top expressed in neural layer of retina mesenteric lymph nodes ventricular zone thymus superior surface of tongue genital tubercle median eminence paraventricular nucleus of hypothalamus maxillary prominence mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding Cellular component membrane nucleus nucleoplasm mRNA cleavage factor complex cytoplasm mRNA cleavage and polyadenylation specificity factor complex Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing mRNA 3'-end processing protein tetramerization protein heterotetramerization pre-mRNA cleavage required for polyadenylation mRNA alternative polyadenylation messenger ribonucleoprotein complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79869 269061 Ensembl ENSG00000149532 ENSMUSG00000034820 UniProt Q8N684 Q8BTV2 RefSeq (mRNA) NM_001136040 NM_001142565 NM_024811 NM_001164272 NM_172302 NM_001362450 RefSeq (protein) NP_001129512 NP_001136037 NP_079087 NP_001157744 NP_758506 NP_001349379 Location (UCSC) Chr 11: 61.4 – 61.43 Mb Chr 19: 10.5 – 10.53 Mb PubMed search [3] [4]
Wikidata
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Cleavage and polyadenylation specificity factor subunit 7 is a protein that in humans is encoded by the CPSF7 gene. ^{[5] [6]}

Function

CPSF7, also known as CFIm59, is the cleavage factor of two closely associated protein complexes in the 3' untranslated region of a newly synthesized pre-messenger RNA (mRNA) molecule used in gene transcription. ^[7] CPSF7 is one of three Cleavage and polyadenylation specificity factors (CPSF), the other two being CFIm25 (or CPSF5/NUDT21) and CFIm68 (or CPSF6).

References

1. GRCh38: Ensembl release 89: ENSG00000149532 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034820 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
6. "Entrez Gene: FLJ12529 pre-mRNA cleavage factor I, 59 kDa subunit".
7. Hardy JG, Norbury CJ (August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–7. doi:10.1042/BST20160078. PMID   27528751. S2CID   206156045.

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID   15144186.
• Rüegsegger U, Beyer K, Keller W (March 1996). "Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". The Journal of Biological Chemistry. 271 (11): 6107–13. doi: 10.1074/jbc.271.11.6107 . PMID   8626397.