CREB5

CREB5
Identifiers
Aliases	CREB5 , CRE-BPA, CREB-5, cAMP responsive element binding protein 5, CREBPA
External IDs	OMIM: 618262; MGI: 2443973; HomoloGene: 18215; GeneCards: CREB5; OMA:CREB5 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p15.1-p14.3 Start 28,299,321 bp [1] End 28,825,894 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 B3|6 25.9 cM Start 53,264,255 bp [2] End 53,677,361 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint ventricular zone blood corpus callosum tendon of biceps brachii monocyte inferior ganglion of vagus nerve synovial membrane internal globus pallidus cartilage tissue Top expressed in hand ascending aorta aortic valve foot lumbar subsegment of spinal cord hair follicle ventricular zone genital tubercle external carotid artery internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component extracellular exosome nucleus Biological process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9586 231991 Ensembl ENSG00000146592 ENSMUSG00000053007 UniProt Q02930 Q8K1L0 RefSeq (mRNA) NM_001011666 NM_004904 NM_182898 NM_182899 NM_172728 NM_001327821 RefSeq (protein) NP_001011666 NP_004895 NP_878901 NP_878902 NP_001314750 NP_766316 Location (UCSC) Chr 7: 28.3 – 28.83 Mb Chr 6: 53.26 – 53.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cyclic AMP-responsive element-binding protein 5 is a protein that in humans is encoded by the CREB5 gene. ^{[5] [6] [7]}

The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, ^[8] and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000146592 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053007 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zu YL, Maekawa T, Nomura N, Nakata T, Ishii S (Oct 1993). "Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter TPA". Oncogene. 8 (10): 2749–58. PMID   8378084.
6. Nomura N, Zu YL, Maekawa T, Tabata S, Akiyama T, Ishii S (Mar 1993). "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1". J Biol Chem. 268 (6): 4259–66. doi: 10.1016/S0021-9258(18)53604-8 . PMID   8440710.
7. "Entrez Gene: CREB5 cAMP responsive element binding protein 5".
8. Cumulated Index Medicus. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine. 1993.

External links

• Human CREB5 genome location and CREB5 gene details page in the UCSC Genome Browser .

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID   11329013. S2CID   25064683.
• <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.