CRIP1

CRIP1
Identifiers
Aliases	CRIP1 , CRHP, CRIP, CRP-1, CRP1, cysteine rich protein 1
External IDs	OMIM: 123875 MGI: 88501 HomoloGene: 37465 GeneCards: CRIP1
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q32.33 Start 105,486,317 bp [1] End 105,488,947 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12 F1|12 61.59 cM Start 113,109,936 bp [2] End 113,117,499 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery left coronary artery popliteal artery right uterine tube ascending aorta duodenum monocyte skin of abdomen lymph node upper lobe of left lung Top expressed in left colon crypt of lieberkuhn of small intestine duodenum ankle belly cord carotid body Paneth cell lip right lung lobe cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide binding DNA binding, bending metal ion binding minor groove of adenine-thymine-rich DNA binding zinc ion binding Cellular component cytoplasm Biological process regulation of gene expression prostate gland stromal morphogenesis cellular response to antibiotic heart development response to zinc ion cell population proliferation cellular response to UV-B response to organic substance immune response intrinsic apoptotic signaling pathway in response to DNA damage Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1396 12925 Ensembl ENSG00000213145 ENSMUSG00000006360 UniProt P50238 P63254 RefSeq (mRNA) NM_001311 NM_007763 RefSeq (protein) NP_001302 NP_031789 Location (UCSC) Chr 14: 105.49 – 105.49 Mb Chr 12: 113.11 – 113.12 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cysteine-rich protein 1 is a protein that in humans is encoded by the CRIP1 gene. ^{[5] [6]}

Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991).[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000213145 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006360 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Garcia-Barcelo M, Tsui SK, Chim SS, Fung KP, Lee CY, Waye MM (Apr 1998). "Mapping of the human cysteine-rich intestinal protein gene CRIP1 to the human chromosomal segment 7q11.23". Genomics. 47 (3): 419–422. doi:10.1006/geno.1997.5134. PMID   9480758.
6. "Entrez Gene: CRIP1 cysteine-rich protein 1 (intestinal)".

External links

• Human CRIP1 genome location and CRIP1 gene details page in the UCSC Genome Browser .

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Khoo C, Blanchard RK, Sullivan VK, Cousins RJ (1997). "Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells". Protein Expr. Purif. 9 (3): 379–387. doi:10.1006/prep.1996.0709. PMID   9126610.
• Khoo C, Cousins RJ (1994). "Purification and properties of rat cysteine-rich intestinal protein". Biochem. J. 299 (2): 445–50. doi:10.1042/bj2990445. PMC   1138292 . PMID   8172605.
• Tsui SK, Yam NY, Lee CY, Waye MM (1995). "Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart". Biochem. Biophys. Res. Commun. 205 (1): 497–505. doi:10.1006/bbrc.1994.2693. PMID   7999070.
• Hempe JM, Cousins RJ (1991). "Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport". Proc. Natl. Acad. Sci. U.S.A. 88 (21): 9671–9674. Bibcode:1991PNAS...88.9671H. doi: 10.1073/pnas.88.21.9671 . PMC   52780 . PMID   1946385.