CSRP1

CSRP1
Identifiers
Aliases	CSRP1 , CRP, CRP1, CSRP, CYRP, D1S181E, HEL-141, HEL-S-286, cysteine and glycine rich protein 1
External IDs	OMIM: 123876; MGI: 88549; HomoloGene: 37874; GeneCards: CSRP1; OMA:CSRP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 201,483,530 bp [1] End 201,509,456 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 135,647,799 bp [2] End 135,679,970 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries right coronary artery muscle layer of sigmoid colon saphenous vein body of uterus left uterine tube gastric mucosa tail of epididymis smooth muscle tissue Top expressed in ascending aorta aortic valve tunica media of zone of aorta seminal vesicula uterus deep cerebellar nuclei globus pallidus umbilical cord pyloric antrum lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding RNA binding zinc ion binding Cellular component extracellular exosome focal adhesion nucleus Biological process platelet aggregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1465 13007 Ensembl ENSG00000159176 ENSMUSG00000026421 UniProt P21291 P97315 RefSeq (mRNA) NM_004078 NM_001144773 NM_001193570 NM_001193571 NM_001193572 NM_007791 NM_001360782 RefSeq (protein) NP_001180499 NP_001180500 NP_001180501 NP_004069 NP_031817 NP_001347711 Location (UCSC) Chr 1: 201.48 – 201.51 Mb Chr 1: 135.65 – 135.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cysteine and glycine-rich protein 1 is a protein that in humans is encoded by the CSRP1 gene. ^{[5] [6] [7]}

CSRP1 is a member of the CSRP family of genes encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in CRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation Other genes in the family include CSRP2 and CSRP3. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000159176 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026421 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liebhaber SA, Emery JG, Urbanek M, Wang XK, Cooke NE (Aug 1990). "Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif". Nucleic Acids Res. 18 (13): 3871–9. doi:10.1093/nar/18.13.3871. PMC   331088 . PMID   2115670.
6. Erdel M, Weiskirchen R (Mar 1999). "Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human chromosome 1q32 by fluorescence in situ hybridization". Cytogenet Cell Genet. 83 (1–2): 10–1. doi:10.1159/000015152. PMID   9925910. S2CID   28018584.
7. "Entrez Gene: CSRP1 cysteine and glycine-rich protein 1".

External links

• Human CRP genome location and CRP gene details page in the UCSC Genome Browser .
• Human CSRP1 genome location and CSRP1 gene details page in the UCSC Genome Browser .

Further reading

• Weiskirchen R, Günther K (2003). "The CRP/MLP/TLP family of LIM domain proteins: acting by connecting". BioEssays. 25 (2): 152–62. doi:10.1002/bies.10226. PMID   12539241. S2CID   21364125.
• Wang X, Lee G, Liebhaber SA, Cooke NE (1992). "Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc". J. Biol. Chem. 267 (13): 9176–84. doi: 10.1016/S0021-9258(19)50405-7 . PMID   1374386.
• Wang X, Ray K, Szpirer J, et al. (1992). "Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism". Genomics. 14 (2): 391–7. doi: 10.1016/S0888-7543(05)80231-9 . hdl: 2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/94704 . PMID   1385304.
• Feuerstein R, Wang X, Song D, et al. (1994). "The LIM/double zinc-finger motif functions as a protein dimerization domain". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10655–9. Bibcode:1994PNAS...9110655F. doi: 10.1073/pnas.91.22.10655 . PMC   45080 . PMID   7938009.
• Dubé JY, Chapdelaine P, Trahan PL, et al. (1998). "Abundant cysteine-rich protein-1 is localized in the stromal compartment of the human prostate". Arch. Androl. 40 (2): 109–15. doi:10.3109/01485019808987933. PMID   9507743.
• Harper BD, Beckerle MC, Pomiès P (2001). "Fine mapping of the alpha-actinin binding site within cysteine-rich protein". Biochem. J. 350 Pt 1 (Pt 1): 269–74. doi:10.1042/0264-6021:3500269. PMC   1221251 . PMID   10926853.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Hirasawa Y, Arai M, Imazeki F, et al. (2007). "Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma". Oncology. 71 (1–2): 77–85. doi: 10.1159/000100475 . PMID   17341888. S2CID   40174270.
• Wang Q, Williamson M, Bott S, et al. (2007). "Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer". Oncogene. 26 (45): 6560–5. doi:10.1038/sj.onc.1210472. PMID   17486081. S2CID   19222997.