CSRP2

CSRP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CU8
Identifiers
Aliases	CSRP2 , CRP2, LMO5, SmLIM, cysteine and glycine rich protein 2
External IDs	OMIM: 601871 MGI: 1202907 HomoloGene: 111061 GeneCards: CSRP2
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q21.2 Start 76,858,709 bp [1] End 76,879,023 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D1 Start 110,755,650 bp [2] End 110,775,483 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ganglionic eminence right coronary artery parietal pleura gastric mucosa optic nerve left coronary artery ascending aorta urethra Top expressed in ascending aorta aortic valve belly cord endocardial cushion atrium external carotid artery atrioventricular valve internal carotid artery maxillary prominence abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding molecular function structural constituent of muscle actinin binding Cellular component nucleus focal adhesion cytoplasm Z disc Biological process multicellular organism development cell differentiation actin cytoskeleton organization sarcomere organization muscle tissue development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1466 13008 Ensembl ENSG00000175183 ENSMUSG00000020186 UniProt Q16527 P97314 RefSeq (mRNA) NM_001300965 NM_001321 NM_007792 RefSeq (protein) NP_001287894 NP_001312 NP_031818 Location (UCSC) Chr 12: 76.86 – 76.88 Mb Chr 10: 110.76 – 110.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cysteine and glycine-rich protein 2 is a protein that in humans is encoded by the CSRP2 gene. ^{[5] [6] [7]}

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000175183 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020186 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Weiskirchen R, Pino JD, Macalma T, Bister K, Beckerle MC (Jan 1996). "The cysteine-rich protein family of highly related LIM domain proteins". J Biol Chem. 270 (48): 28946–54. doi: 10.1074/jbc.270.48.28946 . PMID   7499425.
6. Weiskirchen R, Erdel M, Utermann G, Bister K (Nov 1997). "Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2". Genomics. 44 (1): 83–93. doi:10.1006/geno.1997.4855. PMID   9286703.
7. "Entrez Gene: CSRP2 cysteine and glycine-rich protein 2".

External links

• Human CSRP2 genome location and CSRP2 gene details page in the UCSC Genome Browser .

Further reading

• Jain MK, Fujita KP, Hsieh CM, Endege WO, Sibinga NE, Yet SF, Kashiki S, Lee WS, Perrella MA (1996). "Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells". J. Biol. Chem. 271 (17): 10194–9. doi: 10.1074/jbc.271.17.10194 . PMID   8626582.
• Karim MA, Ohta K, Egashira M, Jinno Y, Niikawa N, Matsuda I, Indo Y (1997). "Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3". Genomics. 31 (2): 167–76. doi:10.1006/geno.1996.0028. PMID   8824798.
• Weiskirchen R, Gressner AM (2000). "The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)". Biochem. Biophys. Res. Commun. 274 (3): 655–63. doi:10.1006/bbrc.2000.3187. PMID   10924333.
• Weiskirchen R, Moser M, Weiskirchen S, Erdel M, Dahmen S, Buettner R, Gressner AM (2001). "LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1". Biochem. J. 359 (Pt 3): 485–96. doi:10.1042/0264-6021:3590485. PMC   1222169 . PMID   11672422.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Wang M, Hu Y, Shima I, Stearns ME (2003). "IL-10/IL-10 receptor signaling regulates TIMP-1 expression in primary human prostate tumor lines". Cancer Biol. Ther. 1 (5): 556–63. doi: 10.4161/cbt.1.5.222 . PMID   12496489.
• Stearns ME, Wang M, Hu Y, Garcia FU (2004). "Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines". Mol. Cancer Res. 1 (9): 631–42. PMID   12861049.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.